DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Akr1B and GRE3

DIOPT Version :9

Sequence 1:	NP_001261716.1	Gene:	Akr1B / 39304	FlyBaseID:	FBgn0086254	Length:	350	Species:	Drosophila melanogaster
Sequence 2:	NP_011972.1	Gene:	GRE3 / 856504	SGDID:	S000001146	Length:	327	Species:	Saccharomyces cerevisiae

Alignment Length:	311	Identity:	127/311 - (40%)
Similarity:	178/311 - (57%)	Gaps:	32/311 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 DGNEIPVIGLGTFNSPK----GQVTEAVKVAIDAGYRHIDCAYVYQNEDEVGDGVEAKIKEGVVK 104
            :|.::|::|||.:...|    .|:.||:|:    |||..|.|..|.||.|||:|:...|.||:|.
Yeast     9 NGLKMPLVGLGCWKIDKKVCANQIYEAIKL----GYRLFDGACDYGNEKEVGEGIRKAISEGLVS 69

  Fly   105 REDLFITSKLWNTFHRPDLVKSALENTLSSLKLKYLDLYLIHWPMGYK-------------EGCD 156
            |:|:|:.|||||.||.||.||.||:.|||.:.|.|||||.||:|:.:|             .|.|
Yeast    70 RKDIFVVSKLWNNFHHPDHVKLALKKTLSDMGLDYLDLYYIHFPIAFKYVPFEEKYPPGFYTGAD 134

  Fly   157 LFPTDKDGKTLYSPVDYVDTWKAMEKLVEEGLVKSIGVSNFNRRQIERVLEVATIPPVTNQIECH 221
               .:|.|....:.|..:||::|:|:.|:|||:||||||||....|:.:|....|.||..|||.|
Yeast   135 ---DEKKGHITEAHVPIIDTYRALEECVDEGLIKSIGVSNFQGSLIQDLLRGCRIKPVALQIEHH 196

  Fly   222 PYLTQKKLIDFCKSKDITITAYSPLG-----SPNRPWAKAGDPVILEEAKIKEIAAKKK-KTPGQ 280
            |||||:.|::|||..||.:.|||..|     ..:...||. .|.:.|...||:::.... .|..|
Yeast   197 PYLTQEHLVEFCKLHDIQVVAYSSFGPQSFIEMDLQLAKT-TPTLFENDVIKKVSQNHPGSTTSQ 260

  Fly   281 ILIRYQVQRANIVIPKSVTKDRIESNFQV-FDFELTPEEIEIIESFECNGR 330
            :|:|:..||...|||||..|:|:..|.:: ..|.||.:|::.|.:...|.|
Yeast   261 VLLRWATQRGIAVIPKSSKKERLLGNLEIEKKFTLTEQELKDISALNANIR 311

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Akr1B	NP_001261716.1	ARA1	38..316	CDD:223729	122/295 (41%)
Akr1B	NP_001261716.1	Tas	45..>248	CDD:223739	100/224 (45%)
GRE3	NP_011972.1	AKR_SF	3..318	CDD:412396	127/311 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0656
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H116462
Inparanoid	1	1.050	211	1.000	Inparanoid score	I806
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53635
OrthoFinder	1	1.000	-	-		FOG0000042
OrthoInspector	1	1.000	-	-		otm46528
orthoMCL	1	0.900	-	-		OOG6_100072
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1770
SonicParanoid	1	1.000	-	-		X51
TreeFam	1	0.960	-	-
	11	10.760