Protein Alignment Akr1B and AKR1E2

DIOPT Version :9

• Sequence 1: NP_001261716.1
• Gene: Akr1B / 39304
• FlyBaseID: FBgn0086254
• Length: 350
• Species: Drosophila melanogaster
• Sequence 2: XP_011518017.1
• Gene: AKR1E2 / 83592
• HGNCID: 23437
• Length: 341
• Species: Homo sapiens
• Alignment Length: 310
• Identity: 161/310 - (51%)
• Similarity: 197/310 - (63%)
• Gaps: 30/310 - (9%)

  Fly    58 SPKGQVTEAVKVAIDAGYRHIDCAYVYQNEDEVGDGVEAKIKEGVVKREDLFITSKLWNTFHRPD 122
            || |:||||||.||||||||.||||.|.||.|||.|:..|||||.|:||||||.:|||.|.|:..
Human    36 SP-GKVTEAVKEAIDAGYRHFDCAYFYHNEREVGAGIRCKIKEGAVRREDLFIATKLWCTCHKKS 99

  Fly   123 LVKSALENTLSSLKLKYLDLYLIHWPMGYKE-------GC-------------DLFPTDKDGKTL 167
            ||::|...:|.:|||.||||||||||||:|.       .|             || |.|:....:
Human   100 LVETACRKSLKALKLNYLDLYLIHWPMGFKPPHPEWIMSCSELSFCLSHPRVQDL-PLDESNMVI 163

  Fly   168 YSPVDYVDTWKAMEKLVEEGLVKSIGVSNFNRRQIERVLEVATI--PPVTNQIECHPYLTQKKLI 230
            .|..|::|||:|||.||..||||:|||||||..|:||:|....:  .|:|||||||||||||.||
Human   164 PSDTDFLDTWEAMEDLVITGLVKNIGVSNFNHEQLERLLNKPGLRFKPLTNQIECHPYLTQKNLI 228

  Fly   231 DFCKSKDITITAYSPLGSPNRPWAKAGDPVILEEAKIKEIAAKKKKTPGQILIRYQVQRANIVIP 295
            .||:|:|:::|||.|||..........:||      ||.||.:..|:|.|||||:|:||..||||
Human   229 SFCQSRDVSVTAYRPLGGSCEGVDLIDNPV------IKRIAKEHGKSPAQILIRFQIQRNVIVIP 287

  Fly   296 KSVTKDRIESNFQVFDFELTPEEIEIIESFECNGRLVPLLNQYGHPHHPF 345
            .|:|...|:.|.||||||||..:::.|.|...|.||........|..:||
Human   288 GSITPSHIKENIQVFDFELTQHDMDNILSLNRNLRLAMFPITKNHKDYPF 337

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Akr1B	NP_001261716.1	ARA1	38..316	CDD:223729	152/279 (54%)
		Tas	45..>248	CDD:223739	120/211 (57%)
AKR1E2	XP_011518017.1	ARA1	34..322	CDD:223729	156/293 (53%)
		Tas	42..314	CDD:223739	148/278 (53%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154944
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0656
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53635
OrthoDB	1	1.010	-	-		D1016440at2759
OrthoFinder	1	1.000	-	-		FOG0000042
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100072
Panther	1	1.100	-	-	LDO	PTHR11732
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X51
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	11	10.720