DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Akr1B and AKR4C11

DIOPT Version :9

Sequence 1:	NP_001261716.1	Gene:	Akr1B / 39304	FlyBaseID:	FBgn0086254	Length:	350	Species:	Drosophila melanogaster
Sequence 2:	NP_190956.1	Gene:	AKR4C11 / 824555	AraportID:	AT3G53880	Length:	315	Species:	Arabidopsis thaliana

Alignment Length:	289	Identity:	126/289 - (43%)
Similarity:	175/289 - (60%)	Gaps:	11/289 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 GNEIPVIGLGTFNSPKGQVTEAVKVAIDAGYRHIDCAYVYQNEDEVGDGVEAKIKEGVVKREDLF 109
            |.:||.:||||:.:..|.|.:||..|:..||:|||||..|.||.|:|..::....:||||||.||
plant    13 GAKIPSVGLGTWQAAPGVVGDAVAAAVKIGYQHIDCASRYGNEIEIGKVLKKLFDDGVVKREKLF 77

  Fly   110 ITSKLWNTFHRPDLVKSALENTLSSLKLKYLDLYLIHWPMGYKEG-CDLFPTDKDGKTLYSPVDY 173
            ||||:|.|...|..|:.||..||..|:|.|:||||:|||:..|:| .|..|.:      ..|:|.
plant    78 ITSKIWLTDLDPPDVQDALNRTLQDLQLDYVDLYLMHWPVRLKKGTVDFKPEN------IMPIDI 136

  Fly   174 VDTWKAMEKLVEEGLVKSIGVSNFNRRQIERVLEVATIPPVTNQIECHPYLTQKKLIDFCKSKDI 238
            ..||||||.||:.|..::||||||:.:::..::|.|.:||..||:||||...|.||.:|||||.|
plant   137 PSTWKAMEALVDSGKARAIGVSNFSTKKLSDLVEAARVPPAVNQVECHPSWQQHKLHEFCKSKGI 201

  Fly   239 TITAYSPLGSPNRPWAKAGDPVILEEAKIKEIAAKKKKTPGQILIRYQVQRANIVIPKSVTKDRI 303
            .::.|||||||...|.||.   :|:...|:.||.:..|:|.|..:|:.:|..:.::|||..:.||
plant   202 HLSGYSPLGSPGTTWVKAD---VLKSPVIEMIAKEIGKSPAQTALRWGLQMGHSILPKSTNEGRI 263

  Fly   304 ESNFQVFDFELTPEEIEIIESFECNGRLV 332
            ..||.|..:.:..|..:.....| ..|||
plant   264 RENFDVLGWSIPKEMFDKFSKIE-QARLV 291

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Akr1B	NP_001261716.1	ARA1	38..316	CDD:223729	121/271 (45%)
Akr1B	NP_001261716.1	Tas	45..>248	CDD:223739	98/203 (48%)
AKR4C11	NP_190956.1	AKR_AKR4C1-15	6..292	CDD:381351	126/289 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	244	1.000	Domainoid score	I557
eggNOG	1	0.900	-	-		E1_COG0656
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	248	1.000	Inparanoid score	I1036
OMA	1	1.010	-	-		QHG53635
OrthoDB	1	1.010	-	-		D1016440at2759
OrthoFinder	1	1.000	-	-		FOG0000042
OrthoInspector	1	1.000	-	-		otm2923
orthoMCL	1	0.900	-	-		OOG6_100072
Panther	1	1.100	-	-	O	PTHR11732
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X51
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.840