DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Akr1B and AKR1D1

DIOPT Version :9

Sequence 1:	NP_001261716.1	Gene:	Akr1B / 39304	FlyBaseID:	FBgn0086254	Length:	350	Species:	Drosophila melanogaster
Sequence 2:	NP_005980.1	Gene:	AKR1D1 / 6718	HGNCID:	388	Length:	326	Species:	Homo sapiens

Alignment Length:	323	Identity:	161/323 - (49%)
Similarity:	216/323 - (66%)	Gaps:	8/323 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 ARAPKVVCLDGNEIPVIGLGTF----NSPKGQVTEAVKVAIDAGYRHIDCAYVYQNEDEVGDGVE 95
            |.:.::...|||.||:|||||:    ::|||....:||||||.||||||.||:||||.|||:.:.
Human     5 AASHRIPLSDGNSIPIIGLGTYSEPKSTPKGACATSVKVAIDTGYRHIDGAYIYQNEHEVGEAIR 69

  Fly    96 AKIKEGVVKREDLFITSKLWNTFHRPDLVKSALENTLSSLKLKYLDLYLIHWPMGYKEGCDLFPT 160
            .||.||.|:|||:|...|||.|.|.|::|:..||.||..|:|.|:|||:|..||.:|.|.:::|.
Human    70 EKIAEGKVRREDIFYCGKLWATNHVPEMVRPTLERTLRVLQLDYVDLYIIEVPMAFKPGDEIYPR 134

  Fly   161 DKDGKTLYSPVDYVDTWKAMEKLVEEGLVKSIGVSNFNRRQIERVLEVATI--PPVTNQIECHPY 223
            |::||.||...:...||:|||...:.|||||:|||||||||:|.:|....:  .||:||:|||||
Human   135 DENGKWLYHKSNLCATWEAMEACKDAGLVKSLGVSNFNRRQLELILNKPGLKHKPVSNQVECHPY 199

  Fly   224 LTQKKLIDFCKSKDITITAYSPLGSPNRP-WAKAGDPVILEEAKIKEIAAKKKKTPGQILIRYQV 287
            .||.||:.||:..||.||||||||:...| |.....|.:|::|.:..:..:..||..||::|:.:
Human   200 FTQPKLLKFCQQHDIVITAYSPLGTSRNPIWVNVSSPPLLKDALLNSLGKRYNKTAAQIVLRFNI 264

  Fly   288 QRANIVIPKSVTKDRIESNFQVFDFELTPEEIEIIESFECNGRLVPLLNQYGHPHHPFEKDEY 350
            ||..:|||||...:||:.|||:|||.||.||::.||:...|.|.|.||....||.:||. |||
Human   265 QRGVVVIPKSFNLERIKENFQIFDFSLTEEEMKDIEALNKNVRFVELLMWRDHPEYPFH-DEY 326

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Akr1B	NP_001261716.1	ARA1	38..316	CDD:223729	143/284 (50%)
Akr1B	NP_001261716.1	Tas	45..>248	CDD:223739	115/208 (55%)
AKR1D1	NP_005980.1	AKR_AKR1D1-3	15..322	CDD:381335	154/306 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0656
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53635
OrthoDB	1	1.010	-	-		D1016440at2759
OrthoFinder	1	1.000	-	-		FOG0000042
OrthoInspector	1	1.000	-	-		otm41206
orthoMCL	1	0.900	-	-		OOG6_100072
Panther	1	1.100	-	-	O	PTHR11732
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1770
SonicParanoid	1	1.000	-	-		X51
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	10	9.860