Protein Alignment Akr1B and Akr1c12

DIOPT Version :10

• Sequence 1: NP_729726.1
• Gene: Akr1B / 39304
• FlyBaseID: FBgn0086254
• Length: 350
• Species: Drosophila melanogaster
• Sequence 2: NP_038805.2
• Gene: Akr1c12 / 622402
• MGIID: 1351661
• Length: 323
• Species: Mus musculus
• Alignment Length: 315
• Identity: 147/315 - (46%)
• Similarity: 208/315 - (66%)
• Gaps: 11/315 - (3%)

  Fly    44 DGNEIPVIGLGTFNS---PKGQVTEAVKVAIDAGYRHIDCAYVYQNEDEVGDGVEAKIKEGVVKR 105
            ||:.||.:|.||:..   ||.:..||..:|:|.||||:|.||.||.|:|:|..:::|||.|||||
Mouse    12 DGHLIPALGFGTYKPKEVPKSKSLEAACLALDVGYRHVDTAYAYQVEEEIGQAIQSKIKAGVVKR 76

  Fly   106 EDLFITSKLWNTFHRPDLVKSALENTLSSLKLKYLDLYLIHWPMGYKEGCDLFPTDKDGKTLYSP 170
            ||||||:|||....||:|||.|||.:|.||:|.|:||||||:|:..|.|.:..|.|::||.|...
Mouse    77 EDLFITTKLWCGCFRPELVKPALEKSLKSLQLDYVDLYLIHYPVPMKPGDNESPLDENGKFLLDT 141

  Fly   171 VDYVDTWKAMEKLVEEGLVKSIGVSNFNRRQIERVLEVATI--PPVTNQIECHPYLTQKKLIDFC 233
            ||:.|||:.:|:..:.||||||||||||.||:||:|....:  .||.||:|||.||.|.||:|:|
Mouse   142 VDFCDTWERLEECKDAGLVKSIGVSNFNHRQLERILNKPGLKYKPVCNQVECHLYLNQSKLLDYC 206

  Fly   234 KSKDITITAYSPLGSPN-RPWAKAGDPVILEEAKIKEIAAKKKKTPGQILIRYQVQRANIVIPKS 297
            |||||.:.||..||:.. :.|.....||:|.:..:.::|.:.|::|..|.:||..||..:.:.:|
Mouse   207 KSKDIVLVAYGALGTQRYKEWVDQNSPVLLNDPVLCDVAKRNKRSPALIALRYLFQRGIVPLAQS 271

  Fly   298 VTKDRIESNFQVFDFELTPEEIEIIESFECNGRLVP--LLKDAGTHKYYPFHDEY 350
            ..::.:..|.|||:|:|:||:::.::....|.|.:|  .|.|   |..|||.:||
Mouse   272 FKENEMRENLQVFEFQLSPEDMKTLDGLNKNFRYLPAEFLAD---HPEYPFSEEY 323

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Akr1B	NP_729726.1	AKR_SF	45..350	CDD:444925	144/312 (46%)
Akr1c12	NP_038805.2	AKR_AKR1C1-35	6..308	CDD:381334	138/295 (47%)