Protein Alignment Akr1B and AKR1B10

DIOPT Version :10

• Sequence 1: NP_729726.1
• Gene: Akr1B / 39304
• FlyBaseID: FBgn0086254
• Length: 350
• Species: Drosophila melanogaster
• Sequence 2: NP_064695.3
• Gene: AKR1B10 / 57016
• HGNCID: 382
• Length: 316
• Species: Homo sapiens
• Alignment Length: 306
• Identity: 186/306 - (60%)
• Similarity: 228/306 - (74%)
• Gaps: 3/306 - (0%)

  Fly    47 EIPVIGLGTFNSPKGQVTEAVKVAIDAGYRHIDCAYVYQNEDEVGDGVEAKIKEGVVKREDLFIT 111
            ::|::||||:.||.|:|.|||||||||||||||||||||||.|||:.::.||:|..||||||||.
Human    12 KMPIVGLGTWKSPLGKVKEAVKVAIDAGYRHIDCAYVYQNEHEVGEAIQEKIQEKAVKREDLFIV 76

  Fly   112 SKLWNTFHRPDLVKSALENTLSSLKLKYLDLYLIHWPMGYKEGCDLFPTDKDGKTLYSPVDYVDT 176
            ||||.||....||:.|.|.||..|||.|||:||||||.|:|.|.||||.|..|..:.....::|.
Human    77 SKLWPTFFERPLVRKAFEKTLKDLKLSYLDVYLIHWPQGFKSGDDLFPKDDKGNAIGGKATFLDA 141

  Fly   177 WKAMEKLVEEGLVKSIGVSNFNRRQIERVLEVATI--PPVTNQIECHPYLTQKKLIDFCKSKDIT 239
            |:|||:||:|||||::|||||:..|||::|....:  .|||||:||||||||:|||.:|.||.||
Human   142 WEAMEELVDEGLVKALGVSNFSHFQIEKLLNKPGLKYKPVTNQVECHPYLTQEKLIQYCHSKGIT 206

  Fly   240 ITAYSPLGSPNRPWAKAGDPVILEEAKIKEIAAKKKKTPGQILIRYQVQRANIVIPKSVTKDRIE 304
            :|||||||||:|||||..||.:||:.||||||||.|||..|:|||:.:||..||||||||..||.
Human   207 VTAYSPLGSPDRPWAKPEDPSLLEDPKIKEIAAKHKKTAAQVLIRFHIQRNVIVIPKSVTPARIV 271

  Fly   305 SNFQVFDFELTPEEIEIIESFECNGRLVPLLKDAGTHKYYPFHDEY 350
            .|.|||||:|:.||:..|.||..|.|...:|:.:.... |||:.||
Human   272 ENIQVFDFKLSDEEMATILSFNRNWRACNVLQSSHLED-YPFNAEY 316

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Akr1B	NP_729726.1	AKR_SF	45..350	CDD:444925	184/304 (61%)
AKR1B10	NP_064695.3	AKR_AKR1B1-19	10..316	CDD:381333	184/304 (61%)