DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Akr1B and akr1a1

DIOPT Version :9

Sequence 1:	NP_001261716.1	Gene:	Akr1B / 39304	FlyBaseID:	FBgn0086254	Length:	350	Species:	Drosophila melanogaster
Sequence 2:	NP_001016137.1	Gene:	akr1a1 / 548891	XenbaseID:	XB-GENE-1014353	Length:	327	Species:	Xenopus tropicalis

Alignment Length:	320	Identity:	167/320 - (52%)
Similarity:	215/320 - (67%)	Gaps:	19/320 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 GNEIPVIGLGTFNSPKGQVTEAVKVAIDAGYRHIDCAYVYQNEDEVGDGVEAKIKEGV-----VK 104
            |.:||:|||||:.|..|||.:|||.|:..||||||||:||.||.|||:.    |||.|     :.
Frog    13 GQKIPLIGLGTWKSAPGQVKDAVKYALGVGYRHIDCAFVYGNETEVGEA----IKESVGSDKGLS 73

  Fly   105 REDLFITSKLWNTFHRPDLVKSALENTLSSLKLKYLDLYLIHWPMGYKEGCDLFPTDKDGKTLYS 169
            ||::|:||||||..|.||.|:.||..||..|:|.||||||:|||..:|.|..:||.:.||...|.
Frog    74 REEVFVTSKLWNNKHHPDDVECALRKTLQDLQLDYLDLYLMHWPYAFKRGDQIFPQNPDGSVQYD 138

  Fly   170 PVDYVDTWKAMEKLVEEGLVKSIGVSNFNRRQIERVLEVATIPPVTNQIECHPYLTQKKLIDFCK 234
            ..||.||||||||||::||.|:||:||||:|||:.::.:||:.|...|:||||||.|.:||.:|.
Frog   139 LTDYKDTWKAMEKLVKQGLTKAIGLSNFNKRQIDDIISIATVKPAVLQVECHPYLAQNELIAYCH 203

  Fly   235 SKDITITAYSPLGSPNRPWAKAGDPVILEEAKIKEIAAKKKKTPGQILIRYQVQRANIVIPKSVT 299
            :..:..|.|||||||:|.|.|..|||:|||..|..:|.|..|:..|||:|:||||..:.||||||
Frog   204 AHGLVFTGYSPLGSPDRSWRKPEDPVLLEEPGIIAMAKKYGKSEAQILLRWQVQRKVVSIPKSVT 268

  Fly   300 KDRIESNFQVFDFELTPEEIEIIESFECNGR-LVPLL--------NQYGHPHHPFEKDEY 350
            ..||..|||||||.|:.||:::|.:...|.| ::||:        ...|||.:|| .|.|
Frog   269 PTRILQNFQVFDFSLSEEEMQLIGALNKNWRYIIPLITVNGKSVPRDAGHPLYPF-NDPY 327

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Akr1B	NP_001261716.1	ARA1	38..316	CDD:223729	153/275 (56%)
Akr1B	NP_001261716.1	Tas	45..>248	CDD:223739	113/207 (55%)
akr1a1	NP_001016137.1	AKR_AKR1A1-4	10..314	CDD:381332	160/304 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53635
OrthoDB	1	1.010	-	-		D1016440at2759
OrthoFinder	1	1.000	-	-		FOG0000042
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1770
SonicParanoid	1	1.000	-	-		X51
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.960