Protein Alignment Akr1B and AKR1B15

DIOPT Version :9

• Sequence 1: NP_001261716.1
• Gene: Akr1B / 39304
• FlyBaseID: FBgn0086254
• Length: 350
• Species: Drosophila melanogaster
• Sequence 2: NP_001074007.2
• Gene: AKR1B15 / 441282
• HGNCID: 37281
• Length: 344
• Species: Homo sapiens
• Alignment Length: 291
• Identity: 168/291 - (57%)
• Similarity: 207/291 - (71%)
• Gaps: 4/291 - (1%)

  Fly    61 GQVTEAVKVAIDAGYRHIDCAYVYQNEDEVGDGVEAKIKEGVVKREDLFITSKLWNTFHRPDLVK 125
            |:|.|||||||||.||||||||.|:|:.|||:.::.||:|..|.||||||.||:|.||....||:
Human    54 GKVKEAVKVAIDAEYRHIDCAYFYENQHEVGEAIQEKIQEKAVMREDLFIVSKVWPTFFERPLVR 118

  Fly   126 SALENTLSSLKLKYLDLYLIHWPMGYKEGCDLFPTDKDGKTLYSPVDYVDTWKAMEKLVEEGLVK 190
            .|.|.||..|||.|||:||||||.|:|.|.|.||.|..|..:.....::|.|:|||:||:|||||
Human   119 KAFEKTLKDLKLSYLDVYLIHWPQGFKTGDDFFPKDDKGNMISGKGTFLDAWEAMEELVDEGLVK 183

  Fly   191 SIGVSNFNRRQIERVLEVATI--PPVTNQIECHPYLTQKKLIDFCKSKDITITAYSPLGSPNRPW 253
            ::||||||..||||:|....:  .|||||:||||||||:|||.:|.||.||:|||||||||:|||
Human   184 ALGVSNFNHFQIERLLNKPGLKYKPVTNQVECHPYLTQEKLIQYCHSKGITVTAYSPLGSPDRPW 248

  Fly   254 AKAGDPVILEEAKIKEIAAKKKKTPGQILIRYQVQRANIVIPKSVTKDRIESNFQVFDFELTPEE 318
            ||..||.:||:.||||||||.|||..|:|||:.:||...|||||:|...|..|.|||||:|:.||
Human   249 AKPEDPSLLEDPKIKEIAAKHKKTTAQVLIRFHIQRNVTVIPKSMTPAHIVENIQVFDFKLSDEE 313

  Fly   319 IEIIESFECNGRLVPLLNQYGH-PHHPFEKD 348
            :..|.||..|.|... ..::.| ...||:.:
Human   314 MATILSFNRNWRAFD-FKEFSHLEDFPFDAE 343

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Akr1B	NP_001261716.1	ARA1	38..316	CDD:223729	158/256 (62%)
		Tas	45..>248	CDD:223739	115/188 (61%)
AKR1B15	NP_001074007.2	ARA1	56..325	CDD:223729	163/268 (61%)
		Tas	57..317	CDD:223739	158/259 (61%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	357	1.000	Domainoid score	I983
eggNOG	1	0.900	-	-		E1_COG0656
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	373	1.000	Inparanoid score	I2118
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53635
OrthoDB	1	1.010	-	-		D1016440at2759
OrthoFinder	1	1.000	-	-		FOG0000042
OrthoInspector	1	1.000	-	-		otm41206
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11732
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X51
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	12	11.940