Protein Alignment Akr1B and Akr1c19

DIOPT Version :10

• Sequence 1: NP_729726.1
• Gene: Akr1B / 39304
• FlyBaseID: FBgn0086254
• Length: 350
• Species: Drosophila melanogaster
• Sequence 2: NP_001013807.2
• Gene: Akr1c19 / 432720
• MGIID: 2653678
• Length: 323
• Species: Mus musculus
• Alignment Length: 318
• Identity: 158/318 - (49%)
• Similarity: 216/318 - (67%)
• Gaps: 17/318 - (5%)

  Fly    44 DGNEIPVIGLGTF-------NSPKGQVTEAVKVAIDAGYRHIDCAYVYQNEDEVGDGVEAKIKEG 101
            |||.||.:|.||:       |.|    .||:.:|::||:||||.|||||.|:.||..:.:||..|
Mouse    12 DGNFIPALGFGTYKPEEVNENKP----LEAIHLALEAGFRHIDTAYVYQTENHVGQAIRSKIAAG 72

  Fly   102 VVKREDLFITSKLWNTFHRPDLVKSALENTLSSLKLKYLDLYLIHWPMGYKEGCDLFPTDKDGKT 166
            :|||||:|:|:|||.|||||:||:|.||.:|.:|:|.|.||||||:|:..|.|.||||.|:.|||
Mouse    73 LVKREDIFLTTKLWCTFHRPELVRSNLEKSLKNLQLDYADLYLIHYPVQMKPGEDLFPEDEHGKT 137

  Fly   167 LYSPVDYVDTWKAMEKLVEEGLVKSIGVSNFNRRQIERVLEVATI--PPVTNQIECHPYLTQKKL 229
            |:..||...||:||||..:.||||||||||||.||:|::|....:  .||.||:|||.||.|:||
Mouse   138 LFDTVDICATWEAMEKCKDAGLVKSIGVSNFNSRQLEKILNKPGLKYKPVCNQVECHLYLNQRKL 202

  Fly   230 IDFCKSKDITITAYSPLGSPNRP--WAKAGDPVILEEAKIKEIAAKKKKTPGQILIRYQVQRANI 292
            :::||||||.:.||..||| .||  |.....||:|.:..:.::|.|.|::|.||.:||.:||..:
Mouse   203 LNYCKSKDIVLVAYCALGS-QRPKRWVDPSSPVLLNDPILCDMAKKHKRSPAQIALRYHLQRGIV 266

  Fly   293 VIPKSVTKDRIESNFQVFDFELTPEEIEIIESFECNGRLVPLLKDAGTHKYYPFHDEY 350
            |:.:|..::.|:.|.|||:|||..|:::|::|.:.|.|..|.....| |..|||.||:
Mouse   267 VLAQSYKENEIKENIQVFEFELPSEDMKILDSLDRNLRYAPAPFGEG-HPEYPFSDEF 323

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Akr1B	NP_729726.1	AKR_SF	45..350	CDD:444925	156/315 (50%)
Akr1c19	NP_001013807.2	AKR_AKR1C1-35	6..308	CDD:381334	150/300 (50%)