DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Akr1B and AKR1B1

DIOPT Version :9

Sequence 1:	NP_001261716.1	Gene:	Akr1B / 39304	FlyBaseID:	FBgn0086254	Length:	350	Species:	Drosophila melanogaster
Sequence 2:	NP_001619.1	Gene:	AKR1B1 / 231	HGNCID:	381	Length:	316	Species:	Homo sapiens

Alignment Length:	314	Identity:	179/314 - (57%)
Similarity:	235/314 - (74%)	Gaps:	2/314 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 APKVVCLDGNEIPVIGLGTFNSPKGQVTEAVKVAIDAGYRHIDCAYVYQNEDEVGDGVEAKIKEG 101
            |.:::..:|.::|::||||:.||.||||||||||||.||||||||:|||||:|||..::.|::|.
Human     2 ASRLLLNNGAKMPILGLGTWKSPPGQVTEAVKVAIDVGYRHIDCAHVYQNENEVGVAIQEKLREQ 66

  Fly   102 VVKREDLFITSKLWNTFHRPDLVKSALENTLSSLKLKYLDLYLIHWPMGYKEGCDLFPTDKDGKT 166
            |||||:|||.||||.|:|...|||.|.:.|||.|||.||||||||||.|:|.|.:.||.|:.|..
Human    67 VVKREELFIVSKLWCTYHEKGLVKGACQKTLSDLKLDYLDLYLIHWPTGFKPGKEFFPLDESGNV 131

  Fly   167 LYSPVDYVDTWKAMEKLVEEGLVKSIGVSNFNRRQIERVLEVATI--PPVTNQIECHPYLTQKKL 229
            :.|..:.:|||.|||:||:|||||:||:||||..|:|.:|....:  .|..|||||||||||:||
Human   132 VPSDTNILDTWAAMEELVDEGLVKAIGISNFNHLQVEMILNKPGLKYKPAVNQIECHPYLTQEKL 196

  Fly   230 IDFCKSKDITITAYSPLGSPNRPWAKAGDPVILEEAKIKEIAAKKKKTPGQILIRYQVQRANIVI 294
            |.:|:||.|.:|||||||||:|||||..||.:||:.:||.||||..||..|:|||:.:||..:||
Human   197 IQYCQSKGIVVTAYSPLGSPDRPWAKPEDPSLLEDPRIKAIAAKHNKTTAQVLIRFPMQRNLVVI 261

  Fly   295 PKSVTKDRIESNFQVFDFELTPEEIEIIESFECNGRLVPLLNQYGHPHHPFEKD 348
            |||||.:||..||:||||||:.:::..:.|:..|.|:..||:...|..:||.::
Human   262 PKSVTPERIAENFKVFDFELSSQDMTTLLSYNRNWRVCALLSCTSHKDYPFHEE 315

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Akr1B	NP_001261716.1	ARA1	38..316	CDD:223729	170/279 (61%)
Akr1B	NP_001261716.1	Tas	45..>248	CDD:223739	127/204 (62%)
AKR1B1	NP_001619.1	AKR_AKR1B1-19	10..316	CDD:381333	178/306 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154945
Domainoid	1	1.000	357	1.000	Domainoid score	I983
eggNOG	1	0.900	-	-		E1_COG0656
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	373	1.000	Inparanoid score	I2118
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53635
OrthoDB	1	1.010	-	-		D1016440at2759
OrthoFinder	1	1.000	-	-		FOG0000042
OrthoInspector	1	1.000	-	-		otm41206
orthoMCL	1	0.900	-	-		OOG6_100072
Panther	1	1.100	-	-	O	PTHR11732
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1770
SonicParanoid	1	1.000	-	-		X51
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.800