DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Akr1B and ZC443.1

DIOPT Version :9

Sequence 1:	NP_001261716.1	Gene:	Akr1B / 39304	FlyBaseID:	FBgn0086254	Length:	350	Species:	Drosophila melanogaster
Sequence 2:	NP_506205.1	Gene:	ZC443.1 / 179756	WormBaseID:	WBGene00013896	Length:	320	Species:	Caenorhabditis elegans

Alignment Length:	324	Identity:	123/324 - (37%)
Similarity:	178/324 - (54%)	Gaps:	23/324 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 ARAPKVVCLDGNEIPVIGLGTFNSPKGQVTEAVKVAIDAGYRHIDCAYVYQNEDEVGDGVEAKIK 99
            ::.|.....:|..:|.|||||:.....:....::.|:.|||||||.|.:||||.::||.:.....
Worm     3 SKVPIFTLSNGVLMPSIGLGTWQMTGEEGKTVIRNAVLAGYRHIDTATLYQNEHQIGDALAELFA 67

  Fly   100 EGVVKREDLFITSKLWNTFHRPDLVKSALENTLSSLKLKYLDLYLIHWPMGYKEGCDLFPTDKDG 164
            ||::||||:|||:|.:.....||:|:.||.|:|..|:|.|:||||.|.|          .:.||.
Worm    68 EGILKREDIFITTKAFCHEVAPDVVEEALRNSLKRLRLDYVDLYLAHIP----------ASTKDD 122

  Fly   165 KTLYSPVDYVDTWKAMEKLVEEGLVKSIGVSNFNRRQIERVLEVATIPPVTNQIECHPYLTQKKL 229
            .:..|.|...|.|:..||:...||.|:|||||||..||.|::.:..:|...:|:|.|.||.||..
Worm   123 GSFRSDVKVEDIWRGFEKVYGLGLTKAIGVSNFNESQIVRIMNIQKVPIHASQLELHLYLPQKAH 187

  Fly   230 IDFCKSKDITITAYSPLGSPNR--PWAKAGDPVI---------LEEAKIKEIAAKKKKTPGQILI 283
            .:.||..:|.||||:.||||.|  .....|.|:.         :.:..:|.:|.|..|||.|||:
Worm   188 RELCKKHNILITAYATLGSPGRMSVVGSNGRPLFESTQNSENEMNDKHVKALAQKYSKTPAQILL 252

  Fly   284 RYQVQRANIVIPKSVTKDRIESNFQVFDFELTPEEIEIIESFE--CNGRLVPLLNQYGHPHHPF 345
            |..|:...|||||:...:|::.|..:|||.::..|:.::|:.|  ...||....|...||..||
Worm   253 RATVEMGIIVIPKTTNPERMKENINIFDFNISNAEVNLLEAHERTKQERLFWWPNVADHPEDPF 316

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Akr1B	NP_001261716.1	ARA1	38..316	CDD:223729	113/288 (39%)
Akr1B	NP_001261716.1	Tas	45..>248	CDD:223739	85/202 (42%)
ZC443.1	NP_506205.1	AKR_AKR1G1_CeAKR	5..303	CDD:381380	117/307 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0656
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53635
OrthoDB	1	1.010	-	-		D1016440at2759
OrthoFinder	1	1.000	-	-		FOG0000042
OrthoInspector	1	1.000	-	-		mtm4839
orthoMCL	1	0.900	-	-		OOG6_100072
Panther	1	1.100	-	-	O	PTHR11732
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X51
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.830