DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Akr1B and Akr1c3

DIOPT Version :9

Sequence 1:	NP_001261716.1	Gene:	Akr1B / 39304	FlyBaseID:	FBgn0086254	Length:	350	Species:	Drosophila melanogaster
Sequence 2:	NP_612519.1	Gene:	Akr1c3 / 171516	RGDID:	708428	Length:	323	Species:	Rattus norvegicus

Alignment Length:	322	Identity:	148/322 - (45%)
Similarity:	215/322 - (66%)	Gaps:	7/322 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 ARAPKVVCLDGNEIPVIGLGTFNSPKG---QVTEAVKVAIDAGYRHIDCAYVYQNEDEVGDGVEA 96
            ::..|:...||:.|||:|.||:.:.:.   :..|:.|:|||.|:|||||:::||||:|:|..:.:
  Rat     3 SKIQKMELNDGHSIPVLGFGTYATEENLRKKSMESTKIAIDVGFRHIDCSHLYQNEEEIGQAIVS 67

  Fly    97 KIKEGVVKREDLFITSKLWNTFHRPDLVKSALENTLSSLKLKYLDLYLIHWPMGYKEGCDLFPTD 161
            ||::|.|||||:|.|||||:|.|||:||:.:|||:|..|.|.|:||||||:|:..|.|.:|.|.|
  Rat    68 KIEDGTVKREDIFYTSKLWSTSHRPELVRPSLENSLRKLNLDYVDLYLIHFPVSLKPGDELLPQD 132

  Fly   162 KDGKTLYSPVDYVDTWKAMEKLVEEGLVKSIGVSNFNRRQIERVLEVATIP--PVTNQIECHPYL 224
            :.|..:...||..|||:||||..:.||.||||||||||||:|::|....:.  ||.||:|||.||
  Rat   133 EHGNLILDTVDLCDTWEAMEKCKDAGLAKSIGVSNFNRRQLEKILNKPGLKHRPVCNQVECHLYL 197

  Fly   225 TQKKLIDFCKSKDITITAYSPLGSPNRPWAKAGD-PVILEEAKIKEIAAKKKKTPGQILIRYQVQ 288
            .|.||:.:||..||.:.||..||:....:....| ||:|::..:..:|.|.|:||..|.:|||::
  Rat   198 NQSKLLAYCKMNDIVLVAYGALGTQRYKYCINEDTPVLLDDPILCTMAKKYKRTPALIALRYQLE 262

  Fly   289 RANIVIPKSVTKDRIESNFQVFDFELTPEEIEIIESFECNGRLVPLLNQYGHPHHPFEKDEY 350
            |..:.:.||..::||..|.|||||:|..:::||:::.:.|.|..|......||:.|| .|||
  Rat   263 RGIVTLVKSFNEERIRENLQVFDFQLASDDMEILDNLDRNLRYFPANMFKAHPNFPF-SDEY 323

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Akr1B	NP_001261716.1	ARA1	38..316	CDD:223729	136/283 (48%)
Akr1B	NP_001261716.1	Tas	45..>248	CDD:223739	108/207 (52%)
Akr1c3	NP_612519.1	AKR_AKR1C1-35	6..308	CDD:381334	140/301 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0656
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53635
OrthoDB	1	1.010	-	-		D1016440at2759
OrthoFinder	1	1.000	-	-		FOG0000042
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100072
Panther	1	1.100	-	-	O	PTHR11732
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X51
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.830