Protein Alignment Akr1B and AKR1C4

DIOPT Version :10

• Sequence 1: NP_729726.1
• Gene: Akr1B / 39304
• FlyBaseID: FBgn0086254
• Length: 350
• Species: Drosophila melanogaster
• Sequence 2: NP_001809.4
• Gene: AKR1C4 / 1109
• HGNCID: 387
• Length: 323
• Species: Homo sapiens
• Alignment Length: 175
• Identity: 31/175 - (17%)
• Similarity: 62/175 - (35%)
• Gaps: 32/175 - (18%)

  Fly    42 NQLLPVELVDISDDDEDDSSSIVPVRNRQNSVPMSTEVPGVSSVTSRLAKRKRDTPSEE----FL 102
            ||.|..||.:.....:....|:..:...:..:....::.......|....:..|:..|.    |.
Human   117 NQWLRDELANTQQKLQKSEQSVAQLEEEKKHLEFMNQLKKYDDDISPSEDKDSDSSKEPLDDLFP 181

  Fly   103 SQKQQKGKGVVVSGPRRSNLFQEFKFSSPLAEQR--YLYFSRRQMIKELNLD-----------PL 154
            :.:.:.|:|:           |:...|:..|.|:  |...:|.:.:..|.:.           ||
Human   182 NDEDEPGQGI-----------QQQHSSAAAAAQQGGYEIPARLRTLHNLVIQYASQGRYEVAVPL 235

  Fly   155 AGKWITDVISEAGLLNTTQHPDIQILKRTSARVSQGQSAGKKVAS 199
            ..:.:.|:...:|    ..|||:..:....|.|.:.|:..|..|:
Human   236 CKQALEDLEKTSG----HDHPDVATMLNILALVYRDQNKYKDAAN 276

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Akr1B	NP_729726.1	AKR_SF	45..350	CDD:444925	29/172 (17%)
AKR1C4	NP_001809.4	AKR_AKR1C1-35	6..306	CDD:381334	31/175 (18%)