Protein Alignment Akr1B and AKR1A1

DIOPT Version :9

• Sequence 1: NP_001261716.1
• Gene: Akr1B / 39304
• FlyBaseID: FBgn0086254
• Length: 350
• Species: Drosophila melanogaster
• Sequence 2: NP_001189342.1
• Gene: AKR1A1 / 10327
• HGNCID: 380
• Length: 325
• Species: Homo sapiens
• Alignment Length: 316
• Identity: 153/316 - (48%)
• Similarity: 213/316 - (67%)
• Gaps: 11/316 - (3%)

  Fly    45 GNEIPVIGLGTFNSPKGQVTEAVKVAIDAGYRHIDCAYVYQNEDEVGDGVEAKIKEG-VVKREDL 108
            |.::|:|||||:.|..|||..|||.|:..||||||||.:|.||.|:|:.::..:..| .|.||:|
Human    11 GQKMPLIGLGTWKSEPGQVKAAVKYALSVGYRHIDCAAIYGNEPEIGEALKEDVGPGKAVPREEL 75

  Fly   109 FITSKLWNTFHRPDLVKSALENTLSSLKLKYLDLYLIHWPMGYKEGCDLFPTDKDGKTLYSPVDY 173
            |:|||||||.|.|:.|:.||..||:.|:|:||||||:|||..::.|.:.||.:.||...|....|
Human    76 FVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERGDNPFPKNADGTICYDSTHY 140

  Fly   174 VDTWKAMEKLVEEGLVKSIGVSNFNRRQIERVLEVATIPPVTNQIECHPYLTQKKLIDFCKSKDI 238
            .:||||:|.||.:|||:::|:||||.|||:.:|.||::.|...|:||||||.|.:||..|:::.:
Human   141 KETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASVRPAVLQVECHPYLAQNELIAHCQARGL 205

  Fly   239 TITAYSPLGSPNRPWAKAGDPVILEEAKIKEIAAKKKKTPGQILIRYQVQRANIVIPKSVTKDRI 303
            .:||||||||.:|.|....:||:|||..:..:|.|..::|.|||:|:||||..|.||||:|..||
Human   206 EVTAYSPLGSSDRAWRDPDEPVLLEEPVVLALAEKYGRSPAQILLRWQVQRKVICIPKSITPSRI 270

  Fly   304 ESNFQVFDFELTPEEIEIIESFECNGR-LVPLL--------NQYGHPHHPFEKDEY 350
            ..|.:||||..:|||::.:.:...|.| :||:|        ...|||.:|| .|.|
Human   271 LQNIKVFDFTFSPEEMKQLNALNKNWRYIVPMLTVDGKRVPRDAGHPLYPF-NDPY 325

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Akr1B	NP_001261716.1	ARA1	38..316	CDD:223729	138/271 (51%)
		Tas	45..>248	CDD:223739	105/203 (52%)
AKR1A1	NP_001189342.1	ARA1	6..303	CDD:223729	145/291 (50%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0656
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53635
OrthoDB	1	1.010	-	-		D1016440at2759
OrthoFinder	1	1.000	-	-		FOG0000042
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100072
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1770
SonicParanoid	1	1.000	-	-		X51
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.760