Protein Alignment Duba and OTUD5

DIOPT Version :10

• Sequence 1: NP_648482.3
• Gene: Duba / 39302
• FlyBaseID: FBgn0036180
• Length: 659
• Species: Drosophila melanogaster
• Sequence 2: XP_005278096.1
• Gene: OTUD5 / 55593
• HGNCID: 25402
• Length: 572
• Species: Homo sapiens
• Alignment Length: 588
• Identity: 183/588 - (31%)
• Similarity: 269/588 - (45%)
• Gaps: 189/588 - (32%)

  Fly   108 AAAGSGAP----GVSGS----KCNSPPSTSTSGSSSP--SAVGRNSPEHLGLGCTTVPTAQVQMS 162
            ||||.||.    ||.|:    .|.|.|..|.....:|  .|||..|||.
Human   120 AAAGVGAAGVVVGVGGAVGVGGCCSGPGHSKRRRQAPGVGAVGGGSPER---------------- 168

  Fly   163 TSTAAANLLKTVEETFSGYNSGDEHHQPKERLIPV--------EEWQRRDLEFAKCM-EQRGYEL 218
                        ||..:||||.||:.....|:..:        |.|      |.|.: :::|:.:
Human   169 ------------EEVGAGYNSEDEYEAAAARIEAMDPATVEQQEHW------FEKALRDKKGFII 215

  Fly   219 KPVEEDGACLFRSISLQIYGDEEMHDVIRQHTMDYIHENREYFGQFVTEDINSYIQRKRARDAHG 283
            |.::||||||||:::.|:|||::||:|:|:|.|||:.:|.:||..:||||..:||.|||..:.||
Human   216 KQMKEDGACLFRAVADQVYGDQDMHEVVRKHCMDYLMKNADYFSNYVTEDFTTYINRKRKNNCHG 280

  Fly   284 NHIEIQAISEIYSRTVEVYCYQS-----NPINIFNS-EQSQAGYPPLRLSYQRGSHYNAILDPYN 342
            ||||:||::|:|:|.||||.|.:     .|||.|:. .|::.  .|:|:||.|..|||::::|..
Human   281 NHIEMQAMAEMYNRPVEVYQYSTGTSAVEPINTFHGIHQNED--EPIRVSYHRNIHYNSVVNPNK 343

  Fly   343 ATVGVGLGLAGYKP----EIQTKEAVRLSEQLEIEQTMFEDKLKTTDWEATNEAIEEQIARESYL 403
            ||:||||||..:||    :...|.|::.||:..|||.|.|||.:.|||||||||||||:||||||
Human   344 ATIGVGLGLPSFKPGFAEQSLMKNAIKTSEESWIEQQMLEDKKRATDWEATNEAIEEQVARESYL 408

  Fly   404 QWCRENTQRSRN----SNTAAGSATSSTVTSAEALTDSDASPSKYSACGGTGSSGNPPVALTSGS 464
            ||.|:..:::|.    |.....|||.|:.|:|                   .|||
Human   409 QWLRDQEKQARQVRGPSQPRKASATCSSATAA-------------------ASSG---------- 444

  Fly   465 GGDGAGPAFSLSPKTLNQFSHKLPQEVNELGGYDSDATDMSSTSSVGHSGGSSSPSTAASQRSGK 529
                           |.:::.:.|::             .||.||..|
Human   445 ---------------LEEWTSRSPRQ-------------RSSASSPEH----------------- 464

  Fly   530 GSKSQRRATALRKKRRHETRETTLASKSAEALEAPL-RKSPKRDSAPSVARADTPEAEQRPSTSK 593
                                         ..|.|.| .|.|...:..::|:..:|.|   |.||.
Human   465 -----------------------------PELHAELGMKPPSPGTVLALAKPPSPCA---PGTSS 497

  Fly   594 QSSHSPQKNVDSKSPTEQSY-----SSFYQELLEASYANEGAN---ESEMLQQAIQMSTRDYMED 650
            |.|....:   :.||....|     .:..|::..:::|  |.|   :.|:|...:.:|.::|::.
Human   498 QFSAGADR---ATSPLVSLYPALECRALIQQMSPSAFA--GLNDWDDDEILASVLAVSQQEYLDS 557

  Fly   651 QKR 653
            .|:
Human   558 MKK 560

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Duba	NP_648482.3	OTU_OTUD5-like	215..339	CDD:438589	63/129 (49%)
		PTZ00449	<432..>634	CDD:185628	30/210 (14%)
OTUD5	XP_005278096.1	OTU_OTUD5-like	212..340	CDD:438589	63/129 (49%)