Protein Alignment Duba and OTUD6B

DIOPT Version :10

• Sequence 1: NP_648482.3
• Gene: Duba / 39302
• FlyBaseID: FBgn0036180
• Length: 659
• Species: Drosophila melanogaster
• Sequence 2: NP_057107.4
• Gene: OTUD6B / 51633
• HGNCID: 24281
• Length: 293
• Species: Homo sapiens
• Alignment Length: 314
• Identity: 71/314 - (22%)
• Similarity: 116/314 - (36%)
• Gaps: 85/314 - (27%)

  Fly    64 DELARTHRCSPH--------------KSTRSKRREHHEAHAHLYK------RDRLEREKLVHPTA 108
            ::|.|.||....              |:.:.:|::..|..|.|.|      |:.||:.||.....
Human    13 EQLLRRHRKEKKELQAKIQGMKNAVPKNDKKRRKQLTEDVAKLEKEMEQKHREELEQLKLTTKEN 77

  Fly   109 AAGSGAPGVSGSKC-NSPP--STSTSGSSSPSAVGRNSPEHLGLGCTTVPTAQVQMSTSTAAANL 170
            ...|.|..:|.... |.||  |.:.......:|:.:...|.:         |:.::...|.|
Human    78 KIDSVAVNISNLVLENQPPRISKAQKRREKKAALEKEREERI---------AEAEIENLTGA--- 130

  Fly   171 LKTVEETFSGYNSGDEHHQPKERLIPVEEWQRRDLEFAKCMEQRGYELKPVEEDGACLFRSISLQ 235
                            .|...|:|             |:.:..|..|:|.:..||.|::::|..|
Human   131 ----------------RHMESEKL-------------AQILAARQLEIKQIPSDGHCMYKAIEDQ 166

  Fly   236 IYGDEEMHDVI--RQHTMDYIHENREYFGQFVT----------EDINSYIQRKRARDAHGNHIEI 288
            :...:....|:  |..|.:|:..:.|.|..|:|          |:...|.:......|.|..:|:
Human   167 LKEKDCALTVVALRSQTAEYMQSHVEDFLPFLTNPNTGDMYTPEEFQKYCEDIVNTAAWGGQLEL 231

  Fly   289 QAISEIYSRTVEVYCYQSNPINIFNSEQSQAGYPPLRLSYQR-----GSHYNAI 337
            :|:|.|....:|:....|.|| |...|.|:   .||.|.|.|     |.|||::
Human   232 RALSHILQTPIEIIQADSPPI-IVGEEYSK---KPLILVYMRHAYGLGEHYNSV 281

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Duba	NP_648482.3	OTU_OTUD5-like	215..339	CDD:438589	39/140 (28%)
		PTZ00449	<432..>634	CDD:185628
OTUD6B	NP_057107.4	OTU_OTUD6	138..282	CDD:438598	42/161 (26%)
		Cys-loop. /evidence=ECO:0000250	152..158		2/5 (40%)
		Variable-loop. /evidence=ECO:0000250	219..229		2/9 (22%)
		His-loop. /evidence=ECO:0000250	267..277		3/9 (33%)