DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7368 and ZNF335

DIOPT Version :9

Sequence 1:	NP_001036599.1	Gene:	CG7368 / 39301	FlyBaseID:	FBgn0036179	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_071378.1	Gene:	ZNF335 / 63925	HGNCID:	15807	Length:	1342	Species:	Homo sapiens

Alignment Length:	568	Identity:	118/568 - (20%)
Similarity:	190/568 - (33%)	Gaps:	141/568 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 PGNIPGLPQ-------FTTSTAP--LVSTVTAAVTDVTVTGTNNPQQQQQQDAAGSSNRYQQQQQ 66
            |.:.||.|:       |.:|.||  |.|......|.:                      |||..:
Human   743 PPSSPGPPEIPPEATTFQSSEAPSLLCSDTLGGATII----------------------YQQGAE 785

  Fly    67 QVTHFGQATMTAGQ---GSSGNKFRGG---QDDAIQGDKYNGHLVASSQQQQQQQQQQQTQYATV 125
            :.|  ..||.||..   ..|..:..||   |...::.:.....|  :|...|...:....|..|:
Human   786 EST--AMATQTALDLLLNMSAQRELGGTALQVAVVKSEDVEAGL--ASPGGQPSPEGATPQVVTL 846

  Fly   126 AYASATATSAATDAL-------------QAGTSGQQQQQQQMQQQQVTAP-----QELTQDLCNA 172
            ..|.....:||...|             ..|.:|.........::..:||     :|...:...|
Human   847 HVAEPGGGAAAESQLGPPDLPQITLAPGPFGGTGYSVITAPPMEEGTSAPGTPYSEEPAGEAAQA 911

  Fly   173 ILQQQVLQ--NTSWQTLTPGTTVADYLSHLPANTLPLSLHHFLKYSAETIKKENQQNVVLQVQTG 235
            ::....|:  .|.:...|.||                .||| ::.:|:........:.:......
Human   912 VVVSDTLKEAGTHYIMATDGT----------------QLHH-IELTADGSISFPSPDALASGAKW 959

  Fly   236 PAIGINTLGTTTISIPQQAEQLTLQPQQQATLQVQTQAAVTATATTATATTAG-------GSGAT 293
            |.:...       .:|:...    :|...|.......:..:|::..||:...|       .|.||
Human   960 PLLQCG-------GLPRDGP----EPPSPAKTHCVGDSQSSASSPPATSKALGLAVPPSPPSAAT 1013

  Fly   294 SGKKKKRKKRSKDRKTKLRPGEIRLGTALDGSPLYMCPECHVAYPEPELLEVHLVGHNLEKRYVC 358
            :..||                             :.|..|..|:|....:|.|...|.....:.|
Human  1014 AASKK-----------------------------FSCKICAEAFPGRAEMESHKRAHAGPGAFKC 1049

  Fly   359 DICQASLKRKDHLTRHKQSHNPERPYICTVCLKAFKRKEQLSLHFVIHSGEKRHQCGECGKGFYR 423
            ..|..|.::...:..|...|:..||:.|:.|..|.|.|:.|..|.:.|:.||...|..||:.|.|
Human  1050 PDCPFSARQWPEVRAHMAQHSSLRPHQCSQCSFASKNKKDLRRHMLTHTKEKPFACHLCGQRFNR 1114

  Fly   424 KDHLRKHTRSHIARRVKAELNSHVRRENGTSMLQ-PVVTEATTAALQHANQ-LASAQQQLQQQQQ 486
            ..||:.|.:         .|:|...|::||...: |..|...|..|...:: ||:....||....
Human  1115 NGHLKFHIQ---------RLHSPDGRKSGTPTARAPTQTPTQTIILNSDDETLATLHTALQSSHG 1170

  Fly   487 QQQQQQQQQQQQQQHHIVITQQQATPQQ-----QQQTSQQQQQQQQMI 529
            ....::.||...|:|.||..:|..|.|:     |:.|:...|..|.::
Human  1171 VLGPERLQQALSQEHIIVAQEQTVTNQEEAAYIQEITTADGQTVQHLV 1218

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7368	NP_001036599.1	C2H2 Zn finger	330..350	CDD:275368	6/19 (32%)
		COG5048	356..>412	CDD:227381	17/55 (31%)
		C2H2 Zn finger	358..378	CDD:275368	4/19 (21%)
		zf-H2C2_2	370..395	CDD:290200	7/24 (29%)
		C2H2 Zn finger	386..406	CDD:275368	7/19 (37%)
		zf-H2C2_2	399..423	CDD:290200	9/23 (39%)
		zf-C2H2	412..434	CDD:278523	8/21 (38%)
		C2H2 Zn finger	414..434	CDD:275368	8/19 (42%)
ZNF335	NP_071378.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..102
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	201..228
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	274..442
		C2H2 Zn finger	467..487	CDD:275368
		C2H2 Zn finger	497..517	CDD:275368
		zf-H2C2_2	509..534	CDD:290200
		C2H2 Zn finger	529..545	CDD:275370
		C2H2 Zn finger	564..584	CDD:275368
		zf-H2C2_2	577..600	CDD:290200
		zf-C2H2	590..612	CDD:278523
		C2H2 Zn finger	592..612	CDD:275368
		C2H2 Zn finger	623..643	CDD:275368
		C2H2 Zn finger	651..672	CDD:275368
		C2H2 Zn finger	680..699	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	732..763		5/19 (26%)
		PRK04654	<795..911	CDD:135173	19/117 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	964..1013		8/59 (14%)
		C2H2 Zn finger	1021..1041	CDD:275368	6/19 (32%)
		Involved in the interaction with CCAR2. /evidence=ECO:0000269\|PubMed:19131338	1041..1342		52/187 (28%)
		C2H2 Zn finger	1049..1069	CDD:275368	4/19 (21%)
		zf-H2C2_5	1075..1097	CDD:290620	7/21 (33%)
		C2H2 Zn finger	1077..1097	CDD:275368	7/19 (37%)
		zf-H2C2_2	1089..1114	CDD:290200	9/24 (38%)
		C2H2 Zn finger	1105..1126	CDD:275368	8/29 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24403
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010