DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7368 and ZNF462

DIOPT Version :9

Sequence 1:	NP_001036599.1	Gene:	CG7368 / 39301	FlyBaseID:	FBgn0036179	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	XP_006717272.1	Gene:	ZNF462 / 58499	HGNCID:	21684	Length:	2567	Species:	Homo sapiens

Alignment Length:	216	Identity:	43/216 - (19%)
Similarity:	79/216 - (36%)	Gaps:	38/216 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   312 RPGEIRLGTALDGSPLYMCPECHVAYPEPELLEVHLVGH------NLEKRYVCDICQASLKRKDH 370
            |||.            |.|.:|.......:.|..|...|      ..|.:|.|..|......:.:
Human  2048 RPGG------------YHCSQCDRVLMSMQGLRSHERSHLALAMFTREDKYSCQYCSFVSAFRHN 2100

  Fly   371 LTRHKQSHN-PERPYICTVCLKAFKRKEQLSLHFV-IHSGEKRHQCGECGKGFYRKDHLRKHTRS 433
            |.||.|:|: ..:|:.|.:|........:|..|.: .|:||..::|..|.........|::|:
Human  2101 LDRHMQTHHGHHKPFRCKLCSFKSSYNSRLKTHILKAHAGEHAYKCSWCSFSTMTISQLKEHS-- 2163

  Fly   434 HIARRVKAELNSHVRRENGTSMLQPVVTEATTAALQHANQLASAQQQLQQQQQQQQQQQQQQQQQ 498
                     |..|.:   ..::.:|.:....::...|::|.|:..::::........:....|||
Human  2164 ---------LKVHGK---ALTLPRPRIVSLLSSHSHHSSQKATPAEEVEDSNDSSYSEPPDVQQQ 2216

  Fly   499 QQHHIVITQQQATPQQQQQTS 519
            ..|:    |..|..:...:.|
Human  2217 LNHY----QSAALARNNSRVS 2233

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7368	NP_001036599.1	C2H2 Zn finger	330..350	CDD:275368	4/19 (21%)
		COG5048	356..>412	CDD:227381	16/57 (28%)
		C2H2 Zn finger	358..378	CDD:275368	6/19 (32%)
		zf-H2C2_2	370..395	CDD:290200	8/25 (32%)
		C2H2 Zn finger	386..406	CDD:275368	4/20 (20%)
		zf-H2C2_2	399..423	CDD:290200	7/24 (29%)
		zf-C2H2	412..434	CDD:278523	4/21 (19%)
		C2H2 Zn finger	414..434	CDD:275368	4/19 (21%)
ZNF462	XP_006717272.1	C2H2 Zn finger	2054..2074	CDD:275368	4/19 (21%)
		C2H2 Zn finger	2088..2108	CDD:275368	6/19 (32%)
		C2H2 Zn finger	2117..2138	CDD:275368	4/20 (20%)
		zf-H2C2_5	2144..2169	CDD:316431	6/35 (17%)
		C2H2 Zn finger	2146..2167	CDD:275368	5/31 (16%)
		C2H2 Zn finger	2317..2337	CDD:275368
		C2H2 Zn finger	2363..2383	CDD:275368
		C2H2 Zn finger	2391..2412	CDD:275368
		C2H2 Zn finger	2477..2497	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24403
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100