DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7368 and ZNF407

DIOPT Version :9

Sequence 1:	NP_001036599.1	Gene:	CG7368 / 39301	FlyBaseID:	FBgn0036179	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_001371404.1	Gene:	ZNF407 / 55628	HGNCID:	19904	Length:	2248	Species:	Homo sapiens

Alignment Length:	268	Identity:	60/268 - (22%)
Similarity:	108/268 - (40%)	Gaps:	73/268 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   295 GKKKKRK------KRSKDRKTKLRPGEIRLGTALDGSPLYMC--PECHVAYPEPELLEVHLVGHN 351
            |..|:||      .||...|..|. ..::|.|   |...:.|  |.||.::.....::.|...|.
Human  1621 GTPKERKFTCHLCDRSFTEKWALN-NHMKLHT---GEKPFKCTWPTCHYSFLTASAMKDHYRTHT 1681

  Fly   352 LEKRYVCDICQASLKRKDHLTRHKQSHNPERPYICTVCLKAFKRKEQLSLHFVIHSGEKRHQCGE 416
            .||.::||:|..:...:..||:|::.|..|:|:.|..|..|...:..|:.|..:|:|||.::|..
Human  1682 GEKSFLCDLCGFAGGTRHALTKHRRQHTGEKPFKCDECNFASTTQSHLTRHKRVHTGEKPYRCPW 1746

  Fly   417 CGKGFYRK---DHLRK---HTRSH------------IARRVKAELNSHVRREN------------ 451
            |.   ||.   :::||   ||..|            ....|..|..:|::.::
Human  1747 CD---YRSNCAENIRKHILHTGKHEGVKMYNCPKCDYGTNVPVEFRNHLKEQHPDIENPDLAYLH 1808

  Fly   452 ---------------GTSMLQPVVTEA--TTAALQHANQLASAQQQLQQQQQQQQQQQQQQQQQQ 499
                           |.:.::   |::  |.|||        |::.|.:::..:..::.....:|
Human  1809 AGIVSKSYECRLKGQGATFVE---TDSPFTAAAL--------AEEPLVKEKPLRSSRRPAPPPEQ 1862

  Fly   500 QHHIVITQ 507
            ...::|.|
Human  1863 VQQVIIFQ 1870

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7368	NP_001036599.1	C2H2 Zn finger	330..350	CDD:275368	5/21 (24%)
		COG5048	356..>412	CDD:227381	18/55 (33%)
		C2H2 Zn finger	358..378	CDD:275368	6/19 (32%)
		zf-H2C2_2	370..395	CDD:290200	9/24 (38%)
		C2H2 Zn finger	386..406	CDD:275368	5/19 (26%)
		zf-H2C2_2	399..423	CDD:290200	8/23 (35%)
		zf-C2H2	412..434	CDD:278523	8/27 (30%)
		C2H2 Zn finger	414..434	CDD:275368	8/25 (32%)
ZNF407	NP_001371404.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..84
		C2H2 Zn finger	188..208	CDD:275368
		C2H2 Zn finger	217..238	CDD:275368
		C2H2 Zn finger	246..268	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	291..322
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	494..515
		C2H2 Zn finger	590..614	CDD:275371
		C2H2 Zn finger	617..639	CDD:275371
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	667..700
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	821..847
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	910..962
		C2H2 Zn finger	1416..1445	CDD:275371
		C2H2 Zn finger	1446..1468	CDD:275371
		C2H2 Zn finger	1488..1509	CDD:275371
		C2H2 Zn finger	1539..1561	CDD:275368
		zf-H2C2_2	1557..1578	CDD:404364
		C2H2 Zn finger	1569..1589	CDD:275368
		C2H2 Zn finger	1597..1617	CDD:275368
		C2H2 Zn finger	1630..1650	CDD:275368	4/20 (20%)
		zf-H2C2_2	1642..1669	CDD:404364	8/30 (27%)
		C2H2 Zn finger	1658..1680	CDD:275368	5/21 (24%)
		C2H2 Zn finger	1688..1708	CDD:275368	6/19 (32%)
		zf-H2C2_2	1700..1725	CDD:404364	9/24 (38%)
		zf-H2C2_5	1714..1738	CDD:404746	6/23 (26%)
		C2H2 Zn finger	1716..1736	CDD:275368	5/19 (26%)
		zf-H2C2_2	1728..1753	CDD:404364	10/27 (37%)
		C2H2 Zn finger	1744..1761	CDD:275368	6/19 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24403
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100