DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7368 and zfp91

DIOPT Version :9

Sequence 1:	NP_001036599.1	Gene:	CG7368 / 39301	FlyBaseID:	FBgn0036179	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	XP_021326898.1	Gene:	zfp91 / 555616	ZFINID:	ZDB-GENE-090313-11	Length:	792	Species:	Danio rerio

Alignment Length:	678	Identity:	148/678 - (21%)
Similarity:	235/678 - (34%)	Gaps:	202/678 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 TFPGNIPGLPQFTTSTAPLV---STVTAAV---TDVTVTGTNNPQQQQQQDAAGSSNRYQQ--QQ 65
            |.|....|.....|.:..::   ||.|..|   ||:     :....:..:||:|:..|..:  ::
Zfish    47 TCPPETNGAATSATGSGRVLRDRSTRTIPVWRQTDI-----SEDLAEVSRDASGNRRRKAKCPRR 106

  Fly    66 QQVTHFGQATMTAGQGSSG-----NKFRGGQDDAIQGDKYNGHLVASSQQQQQQQQQQQTQYAT- 124
            ::......|:..||:.|.|     ::|...: ||:......|..|......:..:...:|.:.:
Zfish   107 RKSPAAAAASSDAGKDSGGDCDLLDEFEENK-DALVNRAARGRRVQVRSGARTCRGSPRTVFKSE 170

  Fly   125 ----VAYASATATSAATDALQAGTSGQQQQQQQMQQQQVTAPQ---------ELTQDLCNAILQQ 176
                |.|..|......|     |||.::::::.|....|...:         |..:...|.|  .
Zfish   171 PEMDVDYVEANKAVEKT-----GTSVEKKEEESMDDDVVEEEECPFVDDPKDENYRPQSNRI--P 228

  Fly   177 QVLQNTSWQTLTPGTTVADYL---SHLPANTLPLSLHHFLKYSAETIKKE---------NQQNVV 229
            .|.:.....|:|..::.:|..   |.:|        |.    ..|||..:         |.|:.
Zfish   229 SVRRQDKHSTMTDSSSDSDEAESSSQIP--------HE----GEETISSDEDVPFRDDLNDQSY- 280

  Fly   230 LQVQTGPAIGINTLGTTTISIPQQAEQLTLQ--PQQQATLQVQTQAAVTATATTATATTAGGSGA 292
                 .|.....:.......:.::.::.|:|  |.:|.| :::|:...|....|......|..
Zfish   281 -----DPKDFSKSKRRPHTRLKEKKDKPTVQETPTEQET-EIKTEGGETTEEQTRAEVEEGAE-- 337

  Fly   293 TSGKKKKRKKRSKDRKT------KLRPGEIRLGTALDGSPLYMCPECHVAYPEPELLEVHL-VGH 350
               ..:||.:|.||.|:      :.:|....:...::|        |......|..|:.|: ..|
Zfish   338 ---PPRKRGRRRKDDKSPRLPKRRKKPPVQYVRCEMEG--------CGTVLAHPRYLQHHIKYQH 391

  Fly   351 NLEKRYVC--DICQASLKRKDHLTRHKQSHNPERPYICTVCLKAFKRKEQLSLHFVIHSGE---- 409
            .::|:|||  ..|....:.:..|.||.:.|..:|.|||..|.:|||....|::|.:||:||
Zfish   392 LMKKKYVCPHPTCGRLFRLQKQLLRHAKHHTDQRDYICEFCARAFKSSHNLAVHRMIHTGEKPLQ 456

  Fly   410 ------------------KRH--------QCGECGKGFYRKDHLRKH-TRSH----IARRVKAEL 443
                              |:|        .|..|||.|.:||.:..| .:||    ||..:.|..
Zfish   457 CEICGFTCRQKASLNWHMKKHDADATYQFSCSICGKKFEKKDSVVAHKAKSHPEVLIAEALAANA 521

  Fly   444 NSHV-----------------RRENGT---------------------------------SMLQP 458
            .:.:                 :.|.|.                                 ||..|
Zfish   522 GALITTPAGVTTLLETNTGSGQTEQGVSETRGSSTVPAGQVAPVTHVGPVMVVDQNHPLHSMQVP 586

  Fly   459 VV-----TEATTAALQHANQLASAQQQLQQQQQQQQQQQQQQQQQQQHHIVIT--QQQATPQQQ- 515
            |.     ||.....||..:. .|.|..||.......||||||.||...|..:|  .||||..||
Zfish   587 VTLALSSTEENNTPLQQTSS-HSLQMPLQFVSSPVSQQQQQQIQQHPLHPSVTSISQQATLVQQL 650

  Fly   516 --QQTSQQQ-----------QQQQQMIN 530
              |..|||.           |||..|::
Zfish   651 PVQSYSQQSPIVHMAFRALPQQQLPMVS 678

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7368	NP_001036599.1	C2H2 Zn finger	330..350	CDD:275368	4/20 (20%)
		COG5048	356..>412	CDD:227381	23/79 (29%)
		C2H2 Zn finger	358..378	CDD:275368	5/21 (24%)
		zf-H2C2_2	370..395	CDD:290200	11/24 (46%)
		C2H2 Zn finger	386..406	CDD:275368	7/19 (37%)
		zf-H2C2_2	399..423	CDD:290200	13/53 (25%)
		zf-C2H2	412..434	CDD:278523	9/30 (30%)
		C2H2 Zn finger	414..434	CDD:275368	8/20 (40%)
zfp91	XP_021326898.1	zf-C2H2_8	368..445	CDD:318181	24/84 (29%)
		C2H2 Zn finger	402..421	CDD:275368	4/18 (22%)
		C2H2 Zn finger	429..449	CDD:275368	7/19 (37%)
		zf-C2H2	456..477	CDD:306579	1/20 (5%)
		C2H2 Zn finger	457..477	CDD:275368	1/19 (5%)
		C2H2 Zn finger	487..503	CDD:275368	7/15 (47%)
		Amelogenin	<633..>716	CDD:330537	16/46 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24403
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.100