DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7368 and Zfp646

DIOPT Version :9

Sequence 1:	NP_001036599.1	Gene:	CG7368 / 39301	FlyBaseID:	FBgn0036179	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_766337.2	Gene:	Zfp646 / 233905	MGIID:	3665412	Length:	1788	Species:	Mus musculus

Alignment Length:	540	Identity:	112/540 - (20%)
Similarity:	169/540 - (31%)	Gaps:	183/540 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 QQQQDAAGSSNRYQQQQQQVTHFGQAT-MTAGQGSSGNKFRGGQDDAIQGDKYNGHLVASSQQQQ 112
            ::...:..||||.:.....:...|.|| |.|..|..|.                   |.|..::.
Mouse   957 ERHHQSQSSSNRTENVPSHLEGAGDATEMVADHGFEGT-------------------VTSVSEEG 1002

  Fly   113 QQQQQQQTQYATVAYASATATSAATDAL--QAGTSGQQQQQQQMQQQQVTAPQELTQDLCNAILQ 175
            ...:.::....|||           |:|  |||.|..:...:..|..|..........|.|   .
Mouse  1003 GDIKSEEGVGGTVA-----------DSLCMQAGESFLESHPRPFQCNQCGKTYRHGGSLVN---H 1053

  Fly   176 QQVLQNTSWQTLTPGTT-----VADYLSHLPANTLPLSLHHFLKYSAETIKKENQQNVVLQVQTG 235
            :::.|...:  :.|..:     :|.|.:|       |..|...|.|              :.|.|
Mouse  1054 RKIHQTGDF--ICPVCSRCYPNLAAYRNH-------LRNHPRCKGS--------------EPQMG 1095

  Fly   236 PAIGINTLGTTTISIPQQAEQLTLQPQQQATL-QVQTQAAVTATATTATATTAGGSGATSGKKKK 299
            |   |:..|  ..|.||.|.:   ..|:||.: |:|.:..|......|            |.|:
Mouse  1096 P---ISEAG--GCSEPQNAAE---AGQEQAVIGQLQEELKVEPLEELA------------GVKE- 1139

  Fly   300 RKKRSKDRKTKLRPGEIRLGTALDGSPLYMCPECHVAYPEPEL-----LEVHLVGHNLEKRYVCD 359
                           |:..|||:....|           |.||     .||     ..|:.:.|:
Mouse  1140 ---------------EVWEGTAVKEEEL-----------EQELETGCQTEV-----TSERPFSCE 1173

  Fly   360 ICQASLKRKDHLTRHKQSHNPERPYICTVCLKAFKRKEQLSLHFVIHSGEKRHQCGECGKGFYRK 424
            :|..:.|....|..|:|||.... :.|..|.|.|.....|..|..||:..::.:|.||||.|..:
Mouse  1174 VCGRTYKHAGSLINHRQSHQTGH-FGCQACSKGFSNLMSLKNHRRIHADPRQFRCSECGKAFRLR 1237

  Fly   425 DHLRKHTRSHIARRVKAELNSHVRRENGTSML----QPVVTEATTAALQHANQLASAQ------- 478
            ..|..|.|.|..|          ||..||..|    :|..........:||..|.:.|
Mouse  1238 KQLANHQRVHAER----------RRSRGTQKLTREDRPFRCGQCGRTYRHAGSLMNHQCNPEASR 1292

  Fly   479 -------------------QQLQQQQQQQQQQ--------------------QQQQQQQQQHHIV 504
                               |::....||::|.                    |...:|..|.|..
Mouse  1293 YSCPFCFKTYSNRTALKDHQRVHSDSQQRRQSGCPQRAAAVRCTLCGCGFSGQGSLEQHLQEHED 1357

  Fly   505 ITQQQATPQQQQQTSQQQQQ 524
            ...:.|:.|..|..::..::
Mouse  1358 TKLEVASGQGGQHATEGSEE 1377

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7368	NP_001036599.1	C2H2 Zn finger	330..350	CDD:275368	5/24 (21%)
		COG5048	356..>412	CDD:227381	16/55 (29%)
		C2H2 Zn finger	358..378	CDD:275368	6/19 (32%)
		zf-H2C2_2	370..395	CDD:290200	9/24 (38%)
		C2H2 Zn finger	386..406	CDD:275368	6/19 (32%)
		zf-H2C2_2	399..423	CDD:290200	10/23 (43%)
		zf-C2H2	412..434	CDD:278523	9/21 (43%)
		C2H2 Zn finger	414..434	CDD:275368	9/19 (47%)
Zfp646	NP_766337.2	C2H2 Zn finger	10..31	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	28..48
		C2H2 Zn finger	69..89	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	139..196
		C2H2 Zn finger	233..253	CDD:275368
		C2H2 Zn finger	260..280	CDD:275368
		C2H2 Zn finger	288..308	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	306..360
		C2H2 Zn finger	368..388	CDD:275368
		C2H2 Zn finger	395..415	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	416..449
		C2H2 Zn finger	459..479	CDD:275368
		C2H2 Zn finger	486..506	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	509..531
		C2H2 Zn finger	568..588	CDD:275368
		C2H2 Zn finger	608..628	CDD:275368
		C2H2 Zn finger	635..655	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	651..712
		C2H2 Zn finger	808..828	CDD:275368
		C2H2 Zn finger	835..855	CDD:275368
		C2H2 Zn finger	868..886	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	889..916
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	956..976		4/18 (22%)
		C2H2 Zn finger	1037..1057	CDD:275368	3/22 (14%)
		C2H2 Zn finger	1064..1084	CDD:275368	5/26 (19%)
		C2H2 Zn finger	1172..1192	CDD:275368	6/19 (32%)
		C2H2 Zn finger	1199..1219	CDD:275368	6/19 (32%)
		C2H2 Zn finger	1227..1247	CDD:275368	9/19 (47%)
		C2H2 Zn finger	1268..1285	CDD:275368	3/16 (19%)
		C2H2 Zn finger	1295..1315	CDD:275368	1/19 (5%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1351..1386		5/27 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1398..1439
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1455..1489
		C2H2 Zn finger	1500..1518	CDD:275368
		C2H2 Zn finger	1526..1544	CDD:275368
		C2H2 Zn finger	1552..1572	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1579..1629
		C2H2 Zn finger	1642..1662	CDD:275368
		C2H2 Zn finger	1669..1689	CDD:275368
		zf-H2C2_2	1681..1706	CDD:372612
		C2H2 Zn finger	1697..1717	CDD:275368
		C2H2 Zn finger	1726..1746	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1744..1788
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24403
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100