DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rt and PMT6

DIOPT Version :9

Sequence 1:	NP_524025.2	Gene:	rt / 39297	FlyBaseID:	FBgn0003292	Length:	886	Species:	Drosophila melanogaster
Sequence 2:	NP_011715.1	Gene:	PMT6 / 853113	SGDID:	S000003431	Length:	759	Species:	Saccharomyces cerevisiae

Alignment Length:	786	Identity:	224/786 - (28%)
Similarity:	364/786 - (46%)	Gaps:	101/786 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   131 SPSRSRSLSCQKQIDKNSAGAASAEERKTANASSQPFTVNLRIDLFSWTLFLLAFGTRFYKLATP 195
            |..:...|.|.:|::         |:.:|...........||..:....|.:.:|..||..:...
Yeast    32 SDIQDEQLDCFEQLE---------EKHRTKKNEEYTALKILRDVIGPLLLTITSFYLRFQHIDQN 87

  Fly   196 PHIVFDELHYGKYISMYMRNIFFFDQHPPLGKQLIAGLVSLAGYDGNYTFTRIGEPYSPEMPIFW 260
            .::|:||.|:||:.|.|:::.::.|.||||||.|||....:||:||.:.|:. ...|...:....
Yeast    88 NYVVWDEAHFGKFGSYYIKHEYYHDVHPPLGKMLIALSEWMAGFDGQFDFSS-NNAYPENVNFKL 151

  Fly   261 FRFLPAMCGSLLAPAVYNLLLEAKLSRWSSALGGLLVVLDNSLLTQSRFVLMESMLLLATTVGIA 325
            .|...|..|:|..|..:........:.::..|...:|.|::|.:..|:|:|::||||..:....|
Yeast   152 MRQFNATFGALCTPVAFFTAKWMGFNYFTVYLIATMVTLEHSYIVLSKFILLDSMLLFFSMTTFA 216

  Fly   326 CLLRF------QRSRLGSLEWFFTGTAAAVCLGAAGTVKYVG-FLALGLAFYLLCRHLWQLLYDA 383
            |:::.      |.::..||....||    :.:|...:||:|| |:.:.:..| .|..|:.|..|.
Yeast   217 CMIKLYTLRKQQMTKKWSLWMLLTG----LSIGCVCSVKWVGLFITVVVGLY-TCIELFLLYCDK 276

  Fly   384 GLTDRQLWMHAISRLLIFVGIPLAVYLGVFYIHFKTLHRAGPHDSIMTSAFQASLDGGLASITKG 448
            .|...:.:.|.:.|::..:.||..:||..|.|||..|:::|..||...:.||.:|:|  ..|..|
Yeast   277 ELPRIKYYKHWLIRIINLIVIPFLIYLYCFKIHFVLLYKSGTGDSTTNTLFQINLEG--TQIEAG 339

  Fly   449 QPLAVVHGSQITLRHTHGRT-CWLHSHAAVYPVRYPDKRGSSHQQQVTCYSFKDVNNWWLVKRPT 512
             |..|..||::|:| :||.: ..||||..|||      .||. |:|:|.|.|.|.||.|..:...
Yeast   340 -PRDVAFGSELTIR-SHGLSPNLLHSHIQVYP------EGSG-QRQITGYGFADSNNVWKFEFSR 395

  Fly   513 KENLVVGDEPDIIRHGEIIQLVHGI--------TSRALNSHDVAAAMTPQCQEVSCYIDYEIKMA 569
            ...|.:.....:  :|:||.:..|:        |...|:||||.:.::....|||   .|..:..
Yeast   396 SSGLELDQNGTL--NGKIIPITDGVEVRLSHKNTGSNLHSHDVPSHVSRGNYEVS---GYGSQSV 455

  Fly   570 GELL--WRVEILNR-DSEGDIW--------HAIKSEVRLVHVSTEASLKFSGRQLPEWGFNQHEV 623
            |:..  |.|||:.: ||...::        |.:.:..||.|......|..:|...|.|||.|.|:
Yeast   456 GDEKDDWIVEIVKQMDSPNPVYSNENSTILHPVSTFFRLRHKVLGCYLASTGLTYPAWGFKQAEI 520

  Fly   624 V-----ADREKAIHEDAIWNVEEHRYTQTEDHRERERQMLTAE-MIPTKRTRISFWAKLLELQSK 682
            |     :.|:|:    ..||||:|.....|          ||| .:|.|.   :||...:.....
Yeast   521 VCKDSWSRRDKS----TWWNVEDHWNHNLE----------TAEDYVPPKS---NFWTDFILTNFA 568

  Fly   683 MLFQTKS-VPNH-MYSSMPH---EWPLMDKGIAYWLDSQSSAQIYLLGNILLWYTATMGILVYAG 742
            |.....: ||:. .|.|:..   |||.:.||:.....:....:.||:|:....:.:|:.::::..
Yeast   569 MASSNNALVPDEDKYDSLSSDAWEWPTLHKGLRMCSWAGYITRYYLMGSPFNTWISTVSLIIFPF 633

  Fly   743 LLAF--YAMRRQRLCFDISEQEWQRFVLAGDTFFMGYVMHYIPYFCVDRTLFLHNYLPAFVFKLL 805
            ::.|  |..|||.|... .:|.|| ..:.|...|:.::.||:|:..:.|..::|:|:||..|.:|
Yeast   634 IILFILYRWRRQTLYLS-DDQIWQ-ITIQGIFPFISWMTHYLPFAMMGRVTYVHHYVPALYFAML 696

  Fly   806 LLCFVVEHLDYLLRRFCTGRGVHLVRLYRLMLILWLVGVLSIFSKFIPFSYGARKMTLNEVRSLR 870
            :..||   ||:.|.|      ||.:..|.:.|.|: .|.:.|::.|.|...|... ...|...|:
Yeast   697 VFGFV---LDFTLTR------VHWMVKYPIYLSLF-GGCIYIYNLFAPICQGMHG-DKAEYLPLQ 750

  Fly   871 WKDTWD 876
            |..|||
Yeast   751 WLSTWD 756

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rt	NP_524025.2	PMT	178..421	CDD:280519	73/249 (29%)
		PMT1	180..877	CDD:224839	216/737 (29%)
		MIR	452..508	CDD:197746	25/56 (45%)
		MIR	522..578	CDD:197746	17/65 (26%)
		MIR	586..642	CDD:197746	19/68 (28%)
		PMT_4TMC	672..875	CDD:292810	56/209 (27%)
PMT6	NP_011715.1	PMT1	44..759	CDD:224839	221/774 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1928
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810