DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rt and PMT5

DIOPT Version :9

Sequence 1:	NP_524025.2	Gene:	rt / 39297	FlyBaseID:	FBgn0003292	Length:	886	Species:	Drosophila melanogaster
Sequence 2:	NP_010190.1	Gene:	PMT5 / 851464	SGDID:	S000002251	Length:	743	Species:	Saccharomyces cerevisiae

Alignment Length:	797	Identity:	216/797 - (27%)
Similarity:	348/797 - (43%)	Gaps:	112/797 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   125 SLSRSPSPSRSRSLSCQKQIDKNSAGAASAEERKTANASSQPFTVNLRIDLFSWTLFLLAFGTRF 189
            ::.|.|    .||....|..|..|:       .:|..:|.:...|.        .|.:.....|.
Yeast    16 TIKRGP----LRSFLITKPCDNLSS-------LRTVTSSKEKLLVG--------CLLIFTAIVRL 61

  Fly   190 YKLATPPHIVFDELHYGKYISMYMRNIFFFDQHPPLGKQLIAGLVSLAGYDGNYTFTRIGEPYSP 254
            :.::.|..:||.|...|.::|.|:.||||.|.||||...|.|.:.|:.||.|.:.:..||..|:.
Yeast    62 HNISLPNSVVFGENEVGTFVSQYVNNIFFTDVHPPLVAMLYATVSSVFGYKGLFNYGNIGTEYTA 126

  Fly   255 EMPIFWFRFLPAMCGSLLAPAVYNLLLEAKLSRWSSALGGLLVVLDNSLLTQSRFVLMESMLLLA 319
            .:|....||..|..|.:....:|..|..:.:....:|:..:...::||.:|.|||.|:|...:..
Yeast   127 NVPYVAMRFFSATLGIVSVLVLYLTLRVSGVKIAVAAICAVCFAIENSFVTLSRFTLIEGPFVFF 191

  Fly   320 TTVGIACLLR-FQRSRL---GSLEWFFTGTAAAVCLGAAGTVKYVGFLALGLAFYLLCRHLWQLL 380
                :||.:. |:||.|   .|.:...:..||::.||.|.:.|:.|...:..|..::...:|.::
Yeast   192 ----MACAVYFFRRSELYLPNSCKANKSLLAASIALGFAVSSKWAGLFTIAWAGIIVLWRVWFMI 252

  Fly   381 YDAGLTDRQLWMHAISRLLIFVGIPLAVYLGVFYIHFKTLHRAGPHDSIMTSAFQASLDGGLASI 445
            .|..........:...:....:.||..:|..:|.:|.|||:..|...|...:.|:.:|.  ..::
Yeast   253 GDLSRPIGSSIKYMAFQFTCLLAIPAFIYFLIFSVHIKTLNVNGISSSFFPAEFRKTLK--YNNV 315

  Fly   446 TKGQPLAVVHGSQITLRHTHGRTCWLHSHAAVYPVRYPDKRGSSHQQQVTCYSFKDVNNWWLVKR 510
            .|.....|..||.::|.|......:||||...||       ..|.|||||.|...|.||.|:::.
Yeast   316 IKETVAEVAVGSAVSLNHVGTAGGYLHSHLHNYP-------AGSMQQQVTLYPHIDQNNKWIIEL 373

  Fly   511 PTKENLVVGDEPDIIRHGEIIQLVHGITSRALNSHDVAAAMTPQC---QEVSCYIDYEIKMAGEL 572
            ....|..|....: :..|.||:|........|:|||....::...   :||||| .|| ...|::
Yeast   374 AEHPNENVTSFQN-LTDGTIIKLRQLKNGCRLHSHDHKPPVSQNADWQKEVSCY-GYE-GFEGDI 435

  Fly   573 L--WRVEILNRDSE----GDIWHAIKSEVRLVHVSTEASLKFSGRQLPEWGFNQHEVVADREKAI 631
            .  |.:||..:.||    .:...||:::.||.|..|...|.....:||||||.|.||..  ....
Yeast   436 NDDWIIEIDKKRSEPGPAQEHIRAIETKFRLKHYLTGCYLFSHPEKLPEWGFGQQEVTC--AYFA 498

  Fly   632 HED-AIWNVEEHRYTQTEDHRERERQMLTAEMIPTKRTRISFWAKLLELQSKMLFQTKSV-PNHM 694
            .|| ..|.:||:         |.|..:...|.:..|  ::|||.|.:.:...|.:....: .:|.
Yeast   499 REDLTSWYIEEN---------ENEISLPNPEKVSYK--KMSFWQKFVAIHKFMFYLNNYMDTSHA 552

  Fly   695 YSSMPHEWPLMDKGIAYWLDSQSSAQIYLLGNILLWYTATMGILVY-----AGLLAF---YAMRR 751
            |||.|..||||.:||.:|  :::..::|.|||.:||::.|..|..:     ..|||:   ..:.|
Yeast   553 YSSEPKTWPLMLRGIDFW--NENGREVYFLGNAVLWWSVTAFICTFIIGVAVELLAWKLGVNILR 615

  Fly   752 QRLCFDISEQEWQRFVLAGDTFFMGYVMHYIPYFCVDRTLFLHNYLPAFVFKLLLLCFVVEHLDY 816
            .:...:...|.:|        :.:|:..||.|||.|.:.|||::||||:.|.:|..
Yeast   616 DKHIINFHYQVFQ--------YLLGFAAHYFPYFFVGQKLFLYDYLPAYYFGILAF--------- 663

  Fly   817 LLRRFCTGRGVHLVRLY---------RLMLILWLVGVLSIFSKFIPFSYGARKMTLNEVRSLRWK 872
                   |..:.|:..|         .:::.:::|.....||:..|..| |...:.|..:..:|.
Yeast   664 -------GHALDLISTYISNKRNNTGYIVVAIFMVVCFYFFSEHSPLIY-ATGWSSNLCKRSKWL 720

  Fly   873 DTWDF-----VLHKNHH 884
            .:|||     :|..:|:
Yeast   721 GSWDFYCNSLLLSDSHY 737

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rt	NP_524025.2	PMT	178..421	CDD:280519	67/246 (27%)
		PMT1	180..877	CDD:224839	202/728 (28%)
		MIR	452..508	CDD:197746	22/55 (40%)
		MIR	522..578	CDD:197746	17/60 (28%)
		MIR	586..642	CDD:197746	20/56 (36%)
		PMT_4TMC	672..875	CDD:292810	57/220 (26%)
PMT5	NP_010190.1	PMT1	22..729	CDD:224839	212/777 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	88	1.000	Domainoid score	I1820
eggNOG	1	0.900	-	-		E1_COG1928
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10050
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	5	4.870