DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rt and PMT1

DIOPT Version :9

Sequence 1:	NP_524025.2	Gene:	rt / 39297	FlyBaseID:	FBgn0003292	Length:	886	Species:	Drosophila melanogaster
Sequence 2:	NP_010188.1	Gene:	PMT1 / 851462	SGDID:	S000002253	Length:	817	Species:	Saccharomyces cerevisiae

Alignment Length:	749	Identity:	213/749 - (28%)
Similarity:	343/749 - (45%)	Gaps:	84/749 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   159 TANASSQPFTVNLRIDLFSWTLFLLAFGTRFYKLATPPHIVFDELHYGKYISMYMRNIFFFDQHP 223
            :|..:|....|.|:..|....|.:.....|.:.||.|..:||||:|:|.:.|.|:|..:|.|.||
Yeast    35 SAELASLRTMVTLKEKLLVACLAVFTAVIRLHGLAWPDSVVFDEVHFGGFASQYIRGTYFMDVHP 99

  Fly   224 PLGKQLIAGLVSLAGYDGNYTFTRIGEPYSPEMPIFWFRFLPAMCGSLLAPAVYNLLLEAKLSRW 288
            ||.|.|.||:.||.|:.|::.|..||:.:....|....||..|..|:|....:|..|..:.:..|
Yeast   100 PLAKMLYAGVASLGGFQGDFDFENIGDSFPSTTPYVLMRFFSASLGALTVILMYMTLRYSGVRMW 164

  Fly   289 SSALGGLLVVLDNSLLTQSRFVLMESMLLLATTVGIACLLRFQRSRLGSLEWFFTGTAAAVCLGA 353
            .:.:..:...::||.:|.||::|:::.|:......:....:::.....||..:.:..|..:.||.
Yeast   165 VALMSAICFAVENSYVTISRYILLDAPLMFFIAAAVYSFKKYEMYPANSLNAYKSLLATGIALGM 229

  Fly   354 AGTVKYVGFLALGLAFYLLCRHLWQLLYDAGLTDRQLWMHAISRLLIFVGIPLAVYLGVFYIHFK 418
            |.:.|:||...:.....|....||.::.|...:.:.::..|.::|...:|:|.|:||..|||||:
Yeast   230 ASSSKWVGLFTVTWVGLLCIWRLWFMIGDLTKSSKSIFKVAFAKLAFLLGVPFALYLVFFYIHFQ 294

  Fly   419 TLHRAGPHDSIMTSAFQASLDGGLASITKGQPLAVVHGSQITLRHTHGRTCWLHSHAAVYPVRYP 483
            :|...|...|..:..|:::|...  .|.:.....|..||.|:|||......:||||:..||
Yeast   295 SLTLDGDGASFFSPEFRSTLKNN--KIPQNVVADVGIGSIISLRHLSTMGGYLHSHSHNYP---- 353

  Fly   484 DKRGSSHQQQVTCYSFKDVNNWWLVK--------RPTKENLVVGDEPDIIRHGEIIQLVHGITSR 540
               ..|.|||.|.|...|.||.||::        ..|.:||..|.:         ::|.|.:|..
Yeast   354 ---AGSEQQQSTLYPHMDANNDWLLELYNAPGESLTTFQNLTDGTK---------VRLFHTVTRC 406

  Fly   541 ALNSHDVAAAMTPQC---QEVSCY----IDYEIKMAGELLWRVEILNRDSEGDIWH----AIKSE 594
            .|:|||....::...   :|||||    .|.:....    |.|||..::|...:..    |:.::
Yeast   407 RLHSHDHKPPVSESSDWQKEVSCYGYSGFDGDANDD----WVVEIDKKNSAPGVAQERVIALDTK 467

  Fly   595 VRLVHVSTEASLKFSGRQLPEWGFNQHEVVADREKAIHEDAIWNVEEHRYTQTEDHRERERQMLT 659
            .||.|..|...|.....:||.|||.|.||.. .....|:..:|.||.:                :
Yeast   468 FRLRHAMTGCYLFSHEVKLPAWGFEQQEVTC-ASSGRHDLTLWYVENN----------------S 515

  Fly   660 AEMIPTKRTRI-----SFWAKLLELQSKMLFQTKS-VPNHMYSSMPHEWPLMDKGIAYWLDSQSS 718
            ..::|....||     ||.:|.:|...||....|: |..|:|.|.|..||.:.:||:||  .:::
Yeast   516 NPLLPEDTKRISYKPASFISKFIESHKKMWHINKNLVEPHVYESQPTSWPFLLRGISYW--GENN 578

  Fly   719 AQIYLLGNILLWYTATMGILVYAGLLAFYAMRRQRLCFDI-SEQEWQRFVLAGDTFFMGYVMHYI 782
            ..:|||||.::|:..|..|.:: ||:....:...:|...| .:.:...|.:....:.:|:.:||.
Yeast   579 RNVYLLGNAIVWWAVTAFIGIF-GLIVITELFSWQLGKPILKDSKVVNFHVQVIHYLLGFAVHYA 642

  Fly   783 PYFCVDRTLFLHNYLPAFVFKLLLLCFVVEHLDYLLRRFCTGRGVHLVRLYRLM----LILWLVG 843
            |.|.:.|.:|||:||||:.|.:|.|...   ||.::.        ::.|..|.|    :|.:|..
Yeast   643 PSFLMQRQMFLHHYLPAYYFGILALGHA---LDIIVS--------YVFRSKRQMGYAVVITFLAA 696

  Fly   844 VLSIFSKFIPFSYGARKMTLNEVRSLRWKDTWDF 877
            .:..|..|.|..||. ..|....:..:|...||:
Yeast   697 SVYFFKSFSPIIYGT-PWTQELCQKSQWLSGWDY 729

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rt	NP_524025.2	PMT	178..421	CDD:280519	72/242 (30%)
		PMT1	180..877	CDD:224839	207/726 (29%)
		MIR	452..508	CDD:197746	23/55 (42%)
		MIR	522..578	CDD:197746	15/62 (24%)
		MIR	586..642	CDD:197746	18/59 (31%)
		PMT_4TMC	672..875	CDD:292810	60/208 (29%)
PMT1	NP_010188.1	PMT1	26..733	CDD:224839	213/749 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	88	1.000	Domainoid score	I1820
eggNOG	1	0.900	-	-		E1_COG1928
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10050
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	5	4.870