DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rt and PMT2

DIOPT Version :9

Sequence 1:	NP_524025.2	Gene:	rt / 39297	FlyBaseID:	FBgn0003292	Length:	886	Species:	Drosophila melanogaster
Sequence 2:	NP_009379.2	Gene:	PMT2 / 851210	SGDID:	S000000021	Length:	759	Species:	Saccharomyces cerevisiae

Alignment Length:	772	Identity:	226/772 - (29%)
Similarity:	359/772 - (46%)	Gaps:	77/772 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   135 SRSLSCQKQIDKNSAGAASAEERKTANASSQPFTVNLRIDLFSWTLFLLAFGTRFYKLATPPHIV 199
            |.|:|..:::  :||....||:......::|...:.|...:.......||..||.||:....|:|
Yeast    28 SSSISVSEEL--SSADERDAEDFSKEKPAAQSSLLRLESVVMPVIFTALALFTRMYKIGINNHVV 90

  Fly   200 FDELHYGKYISMYMRNIFFFDQHPPLGKQLIAGLVSLAGYDGNYTFTRIGEPYSPEMPIFWFRFL 264
            :||.|:||:.|.|:|:.|:.|.||||||.|:.....||||:|::.|.. ||.|...:.....|..
Yeast    91 WDEAHFGKFGSYYLRHEFYHDVHPPLGKMLVGLSGYLAGYNGSWDFPS-GEIYPDYLDYVKMRLF 154

  Fly   265 PAMCGSLLAPAVYNLLLEAKLSRWSSALGGLLVVLDNSLLTQSRFVLMESMLLLATTVGIACLLR 329
            .|...:|..|..|........|..:..|..:||:.:||..|..||:|::||||..|.......:.
Yeast   155 NASFSALCVPLAYFTAKAIGFSLPTVWLMTVLVLFENSYSTLGRFILLDSMLLFFTVASFFSFVM 219

  Fly   330 F--QRSRLGSLEWFFTGTAAAVCLGAAGTVKYVGFLALGLAFYLLCRHLWQLLYDAGLTDRQLWM 392
            |  |||:..|.:|:.......:.||...:||.||...:.:........||..|.|..::.:....
Yeast   220 FHNQRSKPFSRKWWKWLLITGISLGCTISVKMVGLFIITMVGIYTVIDLWTFLADKSMSWKTYIN 284

  Fly   393 HAISRLLIFVGIPLAVYLGVFYIHFKTLHRAGPHDSIMTSAFQASLDGGLASITKGQPLAVVHGS 457
            |.::|:...:.:|..::|..|.|||..|..:|..|:.|.|.|||.|.|  :.:.:|.....:..|
Yeast   285 HWLARIFGLIIVPFCIFLLCFKIHFDLLSHSGTGDANMPSLFQARLVG--SDVGQGPRDIALGSS 347

  Fly   458 QITLRHTHGRTCWLHSHAAVYPVRYPDKRGSSHQQQVTCYSFKDVNNWWLVKR----PT-KENLV 517
            .:::::.......||||...||       ..|:|||||||.:||.||.|...|    |: .||
Yeast   348 VVSIKNQALGGSLLHSHIQTYP-------DGSNQQQVTCYGYKDANNEWFFNRERGLPSWSEN-- 403

  Fly   518 VGDEPDI--IRHGEIIQLVHGITSRALNSHDVAAAMTPQCQEVSCYIDYEIKMAGELL--WRVEI 578
               |.||  ::.|...:|||..|.|.|::|.|||.::....|||.|.|   .:.|:..  |.:||
Yeast   404 ---ETDIEYLKPGTSYRLVHKSTGRNLHTHPVAAPVSKTQWEVSGYGD---NVVGDNKDNWVIEI 462

  Fly   579 LNR--DSEGDIWHAIKSEVRLVHVSTEASLKFSGRQLPEWGFNQHEVVA-----DREKAIHEDAI 636
            :::  |.:.:..|.:.:..|:.::.....|..:|..||||||.|.|||.     .|:|.    ..
Yeast   463 MDQRGDEDPEKLHTLTTSFRIKNLEMGCYLAQTGNSLPEWGFRQQEVVCMKNPFKRDKR----TW 523

  Fly   637 WNVEEHRYTQTEDHRERERQMLTAEMIPTKRTRISFWAKLLELQSKMLFQTKS-VPN----HMYS 696
            ||:|.|         |.||.....|.....:|  :|....:.|...|:....: ||:    ...:
Yeast   524 WNIETH---------ENERLPPRPEDFQYPKT--NFLKDFIHLNLAMMATNNALVPDPDKFDYLA 577

  Fly   697 SMPHEWPLMDKGIAY--WLDSQSSAQIYLLGNILLWYTATMGILVYAGLLAFYAMRRQRLCFDI- 758
            |...:||.::.|:..  |.|  .:.:.:|||.....:.:::.:|.:...:....:|.||...|:
Yeast   578 SSAWQWPTLNVGLRLCGWGD--DNPKYFLLGTPASTWASSVAVLAFMATVVILLIRWQRQYVDLR 640

  Fly   759 SEQEWQRFVLAGDTFFMGYVMHYIPYFCVDRTLFLHNYLPAFVFKLLLL--CFVVEHLDYLLRRF 821
            :...|..|::.|....:.:.:||:|:..:.|..::|:||||..|.|::|  ||     |..|:::
Yeast   641 NPSNWNVFLMGGFYPLLAWGLHYMPFVIMSRVTYVHHYLPALYFALIILAYCF-----DAGLQKW 700

  Fly   822 CTGRGVHLVR--LYRLMLILWLVGVLSIFSKFIPFSYGARKMTLNEVRSLRWKDTWD 876
            ...:...::|  ||...:.|    |:..|..|.|.|:|....:.| .|.|.|..|||
Yeast   701 SRSKCGRIMRFVLYAGFMAL----VIGCFWYFSPISFGMEGPSSN-FRYLNWFSTWD 752

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rt	NP_524025.2	PMT	178..421	CDD:280519	78/244 (32%)
		PMT1	180..877	CDD:224839	217/727 (30%)
		MIR	452..508	CDD:197746	20/55 (36%)
		MIR	522..578	CDD:197746	20/59 (34%)
		MIR	586..642	CDD:197746	19/60 (32%)
		PMT_4TMC	672..875	CDD:292810	52/214 (24%)
PMT2	NP_009379.2	PMT1	44..757	CDD:224839	221/754 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1928
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810