DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rt and Pomt1

DIOPT Version :9

Sequence 1:	NP_524025.2	Gene:	rt / 39297	FlyBaseID:	FBgn0003292	Length:	886	Species:	Drosophila melanogaster
Sequence 2:	NP_445858.1	Gene:	Pomt1 / 84430	RGDID:	620078	Length:	747	Species:	Rattus norvegicus

Alignment Length:	733	Identity:	314/733 - (42%)
Similarity:	460/733 - (62%)	Gaps:	31/733 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly   165 QPFTVNLRIDLFSWTLFLLAFGTRFYKLATPPHIVFDELHYGKYISMYMRNIFFFDQH-PPLGKQ 228
            :|..|.:.|:|....|.:|...||.::|:.|..:||||::||:|||.||:.:||.|.. ||.|..
  Rat    29 RPLVVTIDINLNLVALTVLGLLTRLWQLSYPRAVVFDEVYYGQYISFYMKRVFFLDDSGPPFGHM 93

  Fly   229 LIAGLVSLAGYDGNYTFTRIGEPYSPEMPIFWFRFLPAMCGSLLAPAVYNLLLEAKLSRWSSALG 293
            |:|....|.|:|||:.:.|||..||..:|::..|.|||:.|:|..|..|.::||...|..::...
  Rat    94 LLALGGWLGGFDGNFLWNRIGAEYSSNVPVWSLRLLPALAGALSVPMAYQIVLELHFSHCTAMGA 158

  Fly   294 GLLVVLDNSLLTQSRFVLMESMLLLATTVGIACLLRFQRSRLG---SLEWF----FTGTAAAVCL 351
            .||::::|:|:||||.:|:||:|:....:.:...|:|..|:..   |:.|:    .||.:.:..:
  Rat   159 ALLMLIENALITQSRLMLLESILIFFNLLAVLSYLKFFNSQTHSPFSVHWWLWLMLTGVSCSCAV 223

  Fly   352 GAAGTVKYVGFLALGLAFYLLCRHLWQLLYDAGLTDRQLWMHAISRLLIFVGIPLAVYLGVFYIH 416
            |    :||:|.....|...:...|.|.|:.|..|::..:..|.::|.:..:.:|:.:||..||:|
  Rat   224 G----IKYMGIFTYLLVLSIAAVHAWHLIGDQTLSNICVLSHLLARAVALLVVPVFLYLLFFYVH 284

  Fly   417 FKTLHRAGPHDSIMTSAFQASLDGGLASITKGQPLAVVHGSQITLRHTHGR--TCWLHSHAAVYP 479
            ...|:|:||||.||:|||||||:||||.||:||||.|..|||:||:...|:  .||||||...||
  Rat   285 LMLLYRSGPHDQIMSSAFQASLEGGLARITQGQPLEVAFGSQVTLKSVSGKPLPCWLHSHKNTYP 349

  Fly   480 VRYPDKRGSSHQQQVTCYSFKDVNNWWLVKRPTKENLVVGDEPDIIRHGEIIQLVHGITSRALNS 544
            :.|.:.||||||||||||.|||:||||:||.|.:..|||.:.|..:|||:|:|||||:|:|.||:
  Rat   350 MIYENGRGSSHQQQVTCYPFKDINNWWIVKDPGRHQLVVNNPPRPVRHGDIVQLVHGMTTRLLNT 414

  Fly   545 HDVAAAMTPQCQEVSCYIDYEIKMAGELLWRVEILNRDSEGDIWHAIKSEVRLVHVSTEASLKFS 609
            |||||.::|..|||||||||.|.|..:.||:::|:||:|..|.|..|.||||.|||:|.|.||.|
  Rat   415 HDVAAPLSPHSQEVSCYIDYNISMPAQNLWKLDIVNRESNQDTWKTILSEVRFVHVNTSAILKLS 479

  Fly   610 GRQLPEWGFNQHEVVADR-EKAIHEDAIWNVEEHRYTQTEDHRERERQMLTAEMIPTKR---TRI 670
            |..||:|||.|.|||.:: ....||..:||||||||.:..:.:|||.::.:    ||:.   ..:
  Rat   480 GAHLPDWGFRQLEVVGEKLSLGPHESMVWNVEEHRYGRGHEQKERELELHS----PTQHDISRNL 540

  Fly   671 SFWAKLLELQSKMLFQTKSVPNHMYSSMPHEWPLMDKGIAYWLDSQSSAQIYLLGNILLWYTATM 735
            ||.|:..|||.|||........|.|||.|.||..:|..|||||..::||||:|||||::|.:|::
  Rat   541 SFMARFSELQWKMLTLKNEDLEHQYSSTPLEWLTLDTNIAYWLHPRTSAQIHLLGNIVIWTSASL 605

  Fly   736 GILVYAGLLAFYAMRRQRLCFDISEQEWQRFVLAGDTFFMGYVMHYIPYFCVDRTLFLHNYLPAF 800
            ..:.|..|..:|.:||:|...|:.|..|..:||||.....|:.::|:|:|.::|.|||::||||.
  Rat   606 ATVAYTLLFFWYLLRRRRNICDLPEDAWSHWVLAGALCIGGWALNYLPFFLMERMLFLYHYLPAL 670

  Fly   801 VFKLLLLCFVVEHL-DYLLRRFCTGRGVHLVR-LYRLMLILWLVGVLSIFSKFIPFSYGARKMTL 863
            .|::|||..|::|. |:|.|.       .|.| ::..:::.|......:.:...|.:||...::.
  Rat   671 TFQILLLPIVMQHASDHLCRS-------QLQRNVFSALVVAWYSSACHVSNMLRPLTYGDTSLSP 728

  Fly   864 NEVRSLRWKDTWDFVLHK 881
            .|:|:|||||:||.::.|
  Rat   729 GELRALRWKDSWDILIRK 746

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rt	NP_524025.2	PMT	178..421	CDD:280519	84/250 (34%)
		PMT1	180..877	CDD:224839	308/712 (43%)
		MIR	452..508	CDD:197746	35/57 (61%)
		MIR	522..578	CDD:197746	33/55 (60%)
		MIR	586..642	CDD:197746	31/56 (55%)
		PMT_4TMC	672..875	CDD:292810	79/204 (39%)
Pomt1	NP_445858.1	PMT1	22..742	CDD:224839	312/727 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166339322
Domainoid	1	1.000	208	1.000	Domainoid score	I2778
eggNOG	1	0.900	-	-		E1_COG1928
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H68548
Inparanoid	1	1.050	616	1.000	Inparanoid score	I862
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D101190at33208
OrthoFinder	1	1.000	-	-		FOG0006552
OrthoInspector	1	1.000	-	-		oto98194
orthoMCL	1	0.900	-	-		OOG6_105038
Panther	1	1.100	-	-	LDO	PTHR10050
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X4786
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.760