DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rt and SDF2

DIOPT Version :9

Sequence 1:	NP_524025.2	Gene:	rt / 39297	FlyBaseID:	FBgn0003292	Length:	886	Species:	Drosophila melanogaster
Sequence 2:	XP_011523408.1	Gene:	SDF2 / 6388	HGNCID:	10675	Length:	230	Species:	Homo sapiens

Alignment Length:	190	Identity:	58/190 - (30%)
Similarity:	83/190 - (43%)	Gaps:	32/190 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   440 GGLASITKGQPLAVVH-GSQITLRHTHGRTCWLHSHAAVYPVRYPDKRGS-SHQQQVT-CYSFKD 501
            |||.|......|.||. ||.:.|.:|. ....||||    .|||    || |.||.|| ..|..|
Human    10 GGLWSAVGASSLGVVTCGSVVKLLNTR-HNVRLHSH----DVRY----GSGSGQQSVTGVTSVDD 65

  Fly   502 VNNWWLVKRPTKENLVVGDEPDIIRHGEIIQLVHGITSRALNSHDVAAAMT---PQCQEVSCYID 563
            .|::|.::   .::..|.:....|:.|:.|:|.|..|.|.|:||...:.::   .:.|.:..:.:
Human    66 SNSYWRIR---GKSATVCERGTPIKCGQPIRLTHVNTGRNLHSHHFTSPLSGNQRRKQRLKGFTE 127

  Fly   564 YEIKMAGELLWRVEILNRDSEGDI---WHAI--------KSEVRLVHVSTEASLKFSGRQ 612
            ..||:..:   .|.....:.|||.   |..:        ..|||..|.|||..|..:|.|
Human   128 EGIKLRFK---EVSAFGEEGEGDYLDDWTVLCNGPYWVRDGEVRFKHSSTEVLLSVTGEQ 184

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rt	NP_524025.2	PMT	178..421	CDD:280519
		PMT1	180..877	CDD:224839	58/190 (31%)
		MIR	452..508	CDD:197746	24/58 (41%)
		MIR	522..578	CDD:197746	14/58 (24%)
		MIR	586..642	CDD:197746	12/38 (32%)
		PMT_4TMC	672..875	CDD:292810
SDF2	XP_011523408.1	MIR	22..72	CDD:197746	24/58 (41%)
		MIR	83..157	CDD:197746	18/76 (24%)
		MIR	159..208	CDD:197746	10/26 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1928
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810