DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rt and pomt1

DIOPT Version :9

Sequence 1:	NP_524025.2	Gene:	rt / 39297	FlyBaseID:	FBgn0003292	Length:	886	Species:	Drosophila melanogaster
Sequence 2:	NP_001041532.2	Gene:	pomt1 / 569769	ZFINID:	ZDB-GENE-060929-966	Length:	720	Species:	Danio rerio

Alignment Length:	730	Identity:	321/730 - (43%)
Similarity:	460/730 - (63%)	Gaps:	31/730 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly   166 PFTVNLRIDLFSWTLFLLAFGTRFYKLATPPHIVFDELHYGKYISMYMRNIFFFDQH-PPLGKQL 229
            |.:|.:.|::....:..||..||.|.:..|..:||||::||:::|:||:.:||.|:. ||.|..:
Zfish     7 PVSVTVEINVLLLAVTALALFTRLYGIHFPKAVVFDEVYYGQFLSLYMKQVFFIDESGPPFGHMI 71

  Fly   230 IAGLVSLAGYDGNYTFTRIGEPYSPEMPIFWFRFLPAMCGSLLAPAVYNLLLEAKLSRWSSALGG 294
            :|....|.|:|||:.:.|||..|...:|::..|.:||:.||...|..|.:::|...|.: ||||.
Zfish    72 LALGAYLGGFDGNFVWNRIGAEYPGNVPVWSLRLIPALAGSFCVPLAYLVVVELGYSHF-SALGA 135

  Fly   295 -LLVVLDNSLLTQSRFVLMESMLLLATTVGIACLLRFQRSRLGSLEWFFTGTAAAVCLGAAGTVK 358
             .|:::::||:.||||:|:||:|:....:.:...|||.::|..|.:||:.......|....| ||
Zfish   136 CALLLMEDSLIVQSRFMLLESVLIFFLLLAVLSYLRFHKARNSSFKWFWLVICGVSCAFGIG-VK 199

  Fly   359 YVGFLALGLAFYLLCRHLWQLLYDAGLTDRQLWMHAISRLLIFVGIPLAVYLGVFYIHFKTLHRA 423
            |:|.....|.......|.|||:.|..|:..::..|.:.|.|..|.:|:.:|||.||||...|:|:
Zfish   200 YMGMFTYFLLLSQAAVHTWQLIGDRTLSHGKVMFHVLVRFLALVVLPVIMYLGFFYIHLTLLYRS 264

  Fly   424 GPHDSIMTSAFQASLDGGLASITKGQPLAVVHGSQITLRHTHGR--TCWLHSHAAVYPVRYPDKR 486
            ||||.:|:|||||||:||||.||:||||.|..|||:|||...|:  .||||||.|.||:||.:.|
Zfish   265 GPHDQMMSSAFQASLEGGLARITQGQPLDVAFGSQVTLRTVSGKPVPCWLHSHKANYPIRYENGR 329

  Fly   487 GSSHQQQVTCYSFKDVNNWWLVKRPTKENLVVGDEPDIIRHGEIIQLVHGITSRALNSHDVAAAM 551
            |||||||||||.||||||||::|.|.:::|||...|..:|.|:||||:||:|:|.||:|||||.|
Zfish   330 GSSHQQQVTCYPFKDVNNWWIIKDPGRQSLVVSSPPRPVRRGDIIQLLHGMTTRYLNTHDVAAPM 394

  Fly   552 TPQCQEVSCYIDYEIKMAGELLWRVEILNRDSEGDIWHAIKSEVRLVHVSTEASLKFSGRQLPEW 616
            :|..||||.|||:.:.|..:.||||:|:||:||.:||..|.||||||||:|.|.||.||..||||
Zfish   395 SPHSQEVSGYIDFNVSMPAQNLWRVDIVNRESEKEIWKTILSEVRLVHVNTSAVLKLSGASLPEW 459

  Fly   617 GFNQHEVVADR-EKAIHEDAIWNVEEHRYTQTEDHRERERQMLTAEMIPTK---RTRISFWAKLL 677
            ||.|.|||.|: .|...:..:||||||||.::::.:|||.::.:    ||.   ...::|.||.|
Zfish   460 GFKQLEVVGDKIYKGYQQTGMWNVEEHRYGRSQEPKERELELKS----PTHSDVNKNLTFMAKFL 520

  Fly   678 ELQSKMLFQTKSVPNHMYSSMPHEWPLMDKGIAYWLDSQSSAQIYLLGNILLWYTATMGILVYAG 742
            |||.|||........|.|||.|.||..||..|||||...|:|||:.:|||:.|.|..:.::||..
Zfish   521 ELQWKMLTVKNEESEHKYSSSPLEWITMDTNIAYWLHPSSNAQIHFIGNIVTWTTGNITLVVYCL 585

  Fly   743 LLAFYAMRRQRLCFDISEQEWQRFVLAGDTFFMGYVMHYIPYFCVDRTLFLHNYLPAFVFKLLLL 807
            |...|.:||:|...||.:..|::.||||...|.|:.::|:|:|.:::||||::||||..||:|.:
Zfish   586 LFLTYLIRRRRKVEDIPQDSWEQLVLAGVVCFGGWAVNYLPFFLMEKTLFLYHYLPALTFKILQI 650

  Fly   808 CFVVEHLDYLLRRFCTGRGVHLVR------LYRLMLILWLVGVLSIFSKFIPFSYGARKMTLNEV 866
            ..|.||| |          :|::|      .:..:::..|..|...:....|.:||...:|.:::
Zfish   651 PIVTEHL-Y----------IHVLRSSAQQKAFGGVILAVLCSVYMSYHSLSPLTYGQPALTSDKL 704

  Fly   867 RSLRWKDTWDFVLHK 881
            ..|||:::||.:|.|
Zfish   705 AELRWRESWDILLRK 719

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rt	NP_524025.2	PMT	178..421	CDD:280519	88/244 (36%)
		PMT1	180..877	CDD:224839	315/710 (44%)
		MIR	452..508	CDD:197746	39/57 (68%)
		MIR	522..578	CDD:197746	32/55 (58%)
		MIR	586..642	CDD:197746	33/56 (59%)
		PMT_4TMC	672..875	CDD:292810	79/208 (38%)
pomt1	NP_001041532.2	PMT1	27..715	CDD:224839	313/704 (44%)
		PMT	27..262	CDD:280519	86/236 (36%)
		MIR	293..351	CDD:197746	39/57 (68%)
		MIR	365..422	CDD:197746	32/56 (57%)
		MIR	436..486	CDD:197746	30/49 (61%)
		PMT_4TMC	515..713	CDD:292810	79/208 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170579022
Domainoid	1	1.000	215	1.000	Domainoid score	I2679
eggNOG	1	0.900	-	-		E1_COG1928
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H68548
Inparanoid	1	1.050	624	1.000	Inparanoid score	I841
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D101190at33208
OrthoFinder	1	1.000	-	-		FOG0006552
OrthoInspector	1	1.000	-	-		oto39018
orthoMCL	1	0.900	-	-		OOG6_105038
Panther	1	1.100	-	-	LDO	PTHR10050
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R940
SonicParanoid	1	1.000	-	-		X4786
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.790