DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rt and pomt1

DIOPT Version :9

Sequence 1:	NP_524025.2	Gene:	rt / 39297	FlyBaseID:	FBgn0003292	Length:	886	Species:	Drosophila melanogaster
Sequence 2:	NP_001006756.1	Gene:	pomt1 / 448433	XenbaseID:	XB-GENE-944435	Length:	725	Species:	Xenopus tropicalis

Alignment Length:	728	Identity:	326/728 - (44%)
Similarity:	471/728 - (64%)	Gaps:	23/728 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly   166 PFTVNLRIDLFSWTLFLLAFGTRFYKLATPPHIVFDELHYGKYISMYMRNIFFFDQH-PPLGKQL 229
            |..|.:.|||....|.:|...:|.::|:.|..:||||::||::||:||:.||:.|.. ||||..|
Frog     8 PLVVTVAIDLHFVALTILGLVSRLWRLSYPQAVVFDEVYYGQFISLYMKRIFYLDDSGPPLGHML 72

  Fly   230 IAGLVSLAGYDGNYTFTRIGEPYSPEMPIFWFRFLPAMCGSLLAPAVYNLLLEAKLSRWSSALGG 294
            :|....:|.:|||:.:.|||..||..:|::..|.|||:.|:|..|..|.:::|...|..:....|
Frog    73 LALGGYVADFDGNFMWNRIGAEYSSNVPVWSLRLLPALSGALCVPLAYQIVVELGFSARAGLAAG 137

  Fly   295 LLVVLDNSLLTQSRFVLMESMLLLATTVGIACLLRF---QRSRLGSLEWFF----TGTAAAVCLG 352
            .|::.:|:|:||||.:|:||:|:....:.:...|:|   ||....|:.|:|    ||.:....:|
Frog   138 FLLLFENALITQSRLMLLESVLIFFILLALLSYLKFHGCQRRSPFSVSWWFWLLLTGISCTFAIG 202

  Fly   353 AAGTVKYVGFLALGLAFYLLCRHLWQLLYDAGLTDRQLWMHAISRLLIFVGIPLAVYLGVFYIHF 417
                |||:|..:..|...:...|.|||:.|..|.:..|..|.::|.|..:.:|:.:|||:||:|.
Frog   203 ----VKYMGLFSYLLILGVAAVHYWQLIGDQTLGNVWLLFHLLARCLALLLMPVLLYLGIFYLHL 263

  Fly   418 KTLHRAGPHDSIMTSAFQASLDGGLASITKGQPLAVVHGSQITLRHTHGR--TCWLHSHAAVYPV 480
            ..|.|:||||.||:|||||||:|||:.||:||||.||:||||||::|.|:  .||||||...|||
Frog   264 SILTRSGPHDHIMSSAFQASLEGGLSRITEGQPLEVVYGSQITLKNTLGKPVPCWLHSHKHTYPV 328

  Fly   481 RYPDKRGSSHQQQVTCYSFKDVNNWWLVKRPTKENLVVGDEPDIIRHGEIIQLVHGITSRALNSH 545
            ||...||||||||||||.:|||||||:||.|.::.:||...|..||||:.:||:||:::|.||:|
Frog   329 RYEGGRGSSHQQQVTCYPYKDVNNWWIVKDPARQQMVVDSPPRPIRHGDTVQLLHGMSARFLNTH 393

  Fly   546 DVAAAMTPQCQEVSCYIDYEIKMAGELLWRVEILNRDSEGDIWHAIKSEVRLVHVSTEASLKFSG 610
            ||||..:|..|||||||||.|.|..:.||:|||:||:|:.|.|..|.|||:|:||:|.|:||.||
Frog   394 DVAAPFSPYSQEVSCYIDYNISMPAQSLWKVEIVNRESDMDTWKTIISEVKLIHVNTSAALKLSG 458

  Fly   611 RQLPEWGFNQHEVVADR-EKAIHEDAIWNVEEHRYTQTEDHRERERQMLTAEMIPTKRTRISFWA 674
            ..||:|||.|.|||.|: .|:.|:..:||||||||.::::..|||:::.|:..|...| .:||.:
Frog   459 TALPDWGFRQLEVVGDKASKSYHQSLVWNVEEHRYGRSQEQSEREQELHTSPHIDVGR-NLSFMS 522

  Fly   675 KLLELQSKMLFQTKSVPNHMYSSMPHEWPLMDKGIAYWLDSQSSAQIYLLGNILLWYTATMGILV 739
            :..|||.|||........|.|||.|.:|..||..|||||..:|:|||.||||.::|.:|.:|.|:
Frog   523 RFWELQWKMLTMRTESSEHKYSSYPMDWITMDTSIAYWLHPKSTAQIQLLGNPVIWNSANLGALI 587

  Fly   740 YAGLLAFYAMRRQRLCFDISEQEWQRFVLAGDTFFMGYVMHYIPYFCVDRTLFLHNYLPAFVFKL 804
            |:.||.||.:|::|..:||.:..|:...|.|..|..|:.::|:|:|.:::||||::||||...::
Frog   588 YSALLIFYLLRQRRRIYDIPQGSWEALQLTGVLFLGGWAVNYLPFFLMEKTLFLYHYLPALTCQI 652

  Fly   805 LLLCFVVEHL-DYLLRRFCTGRGVHLVRLYRLMLILWLVGVLSIFSKFIPFSYGARKMTLNEVRS 868
            |||..::||| .:||      |...|...:..:|::|...|...:.|..|.:||...::..|:||
Frog   653 LLLPPLLEHLHQHLL------RSEALQNTFAALLLVWGCSVYLTYRKICPLTYGDPPLSPAELRS 711

  Fly   869 LRWKDTWDFVLHK 881
            |||||.||.::.|
Frog   712 LRWKDNWDILIRK 724

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rt	NP_524025.2	PMT	178..421	CDD:280519	88/250 (35%)
		PMT1	180..877	CDD:224839	319/708 (45%)
		MIR	452..508	CDD:197746	40/57 (70%)
		MIR	522..578	CDD:197746	32/55 (58%)
		MIR	586..642	CDD:197746	31/56 (55%)
		PMT_4TMC	672..875	CDD:292810	82/203 (40%)
pomt1	NP_001006756.1	PMT1	19..720	CDD:224839	319/711 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	212	1.000	Domainoid score	I2734
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H68548
Inparanoid	1	1.050	642	1.000	Inparanoid score	I803
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D101190at33208
OrthoFinder	1	1.000	-	-		FOG0006552
OrthoInspector	1	1.000	-	-		oto104880
Panther	1	1.100	-	-	LDO	PTHR10050
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R940
SonicParanoid	1	1.000	-	-		X4786
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	9.190