Protein Alignment rt and tw

DIOPT Version :10

• Sequence 1: NP_524025.2
• Gene: rt / 39297
• FlyBaseID: FBgn0003292
• Length: 886
• Species: Drosophila melanogaster
• Sequence 2: NP_569858.1
• Gene: tw / 31024
• FlyBaseID: FBgn0086368
• Length: 765
• Species: Drosophila melanogaster
• Alignment Length: 842
• Identity: 247/842 - (29%)
• Similarity: 394/842 - (46%)
• Gaps: 169/842 - (20%)

  Fly   125 SLSRSPSPSRSRSLSCQKQIDKNSAGAASAEERKTANASSQPFTVNLRIDLFSW-----TLFLLA 184
            |:.::|...|..|:   |.:.:|:.        :||..||:....|       |     |:||:.
  Fly     4 SVVKTPKCPRRGSV---KDVAQNAP--------RTAPTSSKEANWN-------WWLLLATVFLVT 50

  Fly   185 FGTRFYKLATPPHIVFDELHYGKYISMYMRNIFFFDQHPPLGKQLIAGLVSLAGYDGNYTFTRIG 249
            |.|||||:..|.||.:||.|:||..|.|:...||||.||||||.||.....|.||:|.:.|.:.|
  Fly    51 FATRFYKVTEPDHICWDETHFGKMGSWYINRTFFFDVHPPLGKMLIGLSGYLTGYNGTFPFEKPG 115

  Fly   250 EPYSPEMPIFWFRFLPAMCGSLLAPAVYNLLLEAKLSRWSSALGGLLVVLDNSLLTQSRFVLMES 314
            :.|: |......|:.....|:|:.|..::.:.:...|..::.|....::.|..|||.::::|::.
  Fly   116 DKYN-ETRYQGMRYFCTTLGALIMPMGFDTVYDLTRSHEAALLAAAYLIFDVGLLTLNQYILLDP 179

  Fly   315 MLLLATTVGIACLLRFQRSRL--GS--LEW----FFTGTAAAVCLGAAGTVKYVGFLALGLAFYL 371
            :||......:..:::..:|..  ||  |.|    |.|||    .|....:||:||...:.|....
  Fly   180 ILLFFMMASVWGMVKVSKSTASGGSYGLRWWLWLFLTGT----MLSCTISVKFVGLFVVLLVGLH 240

  Fly   372 LCRHLWQLLYDAGL----TDRQLWMHAISRLLIFVGIPLAVYLGVFYIHFKTLHRAGPHDSIMTS 432
            ....||.:|.|.|.    |.:||...||: |:::   |:.:|:..||||...|:|:|..|...:|
  Fly   241 TATELWLILGDLGQPILETVKQLACRAIT-LIVW---PVLLYILFFYIHLSVLNRSGNGDGFYSS 301

  Fly   433 AFQASLDGGLASITKGQPLAVVHGSQITLRHTHGRTCWLHSHAAVYPVRYPDKRGSSHQQQVTCY 497
            |||:.|.|. :......|..|.:||.:|:::......:||||..:||     |...:.|||||.|
  Fly   302 AFQSRLIGN-SLYNASMPRDVAYGSLVTIKNHKTGGGYLHSHHHLYP-----KGSGARQQQVTTY 360

  Fly   498 SFKDVNNWWLVKRPTKENLVVGDEPDIIRHGEIIQLVHGITSRALNSHDVAAAMTPQCQEVSCYI 562
            :.||.||.||::...|.....| :..|:|||::::|.|..|.|.|:||:..|.||.:..:|:.|
  Fly   361 THKDENNKWLIRPHNKPGPPKG-KVQILRHGDLVRLTHMATRRNLHSHNEPAPMTKKHLQVTGY- 423

  Fly   563 DYEIKMAGEL-------LWRVEILNRDSEGDIWHAIKSEVRLVHVSTEASLKFSGRQLPEWGFNQ 620
                   |||       :|||.|:. ....:..|.:.|.::.:|:....:|..||:|||:|||.|
  Fly   424 -------GELGLGDANDVWRVLIVG-GKVNETVHTVTSRLKFIHLLQNCALTSSGKQLPKWGFEQ 480

  Fly   621 HEVVAD---REKAIHEDAIWNVEEHRYTQTEDHRERERQMLTAEMIPTKRTRI---SFWAKLLEL 679
            .||..:   |:|    ::.||||::.:                :::|:....:   .|:|:.||.
  Fly   481 QEVSCNPNVRDK----NSQWNVEDNEH----------------KLMPSVSFSVYAPGFFARFLES 525

  Fly   680 QSKMLFQTKSV-PNH-MYSSMPHEWPLMDKGIAYWLDSQSSAQIYLLGNILLWYTATMGILVYAG 742
            .:.||.....: |.. ..:|.|.:||:..:|..:   |.||.:||||||.|:|::..:.:.::..
  Fly   526 HAVMLQGNAGLKPKEGEVTSRPWQWPINYRGQFF---SGSSYRIYLLGNPLIWWSNLVFLALFVT 587

  Fly   743 LLAFYAMRRQRLC-FDISEQEWQRFVLAGDT---------------------------------- 772
            :....|:.:||.. |..|..:.|..|...:|
  Fly   588 VFLCNAVVQQRRAGFARSAAQNQAQVPDSETVAQDEESEHSTTDICSCCTPAKEIVPKAVPSGSP 652

  Fly   773 --------------FFMGYVMHYIPYFCVDRTLFLHNYLPAFVFKLLLLCFVVEHLDYLLRRFCT 823
                          .|:|:::||:|::.:.|.|:.|:|.||.:|..||...:   .:|:||  ..
  Fly   653 EAPNPAQSLRAAAWLFLGWMLHYLPFWAMGRVLYFHHYFPALIFNSLLTGVM---YNYILR--VL 712

  Fly   824 GRGVHLVRLYRLMLILWLVGVLSI----FSKFIPFSYGARKMTLNEVRS----LRWKDTWDF 877
            .:.:|.|       ||.|  ||||    |:.|.|.:||......||..|    |:|..||:|
  Fly   713 PKWIHHV-------ILGL--VLSILVYSFAAFSPLAYGMSGPLANEPNSTMYNLKWLSTWEF 765

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
rt	NP_524025.2	PMT	178..421	CDD:396786	85/259 (33%)
		beta-trefoil_MIR_POMT1	453..644	CDD:467752	69/200 (35%)
		PMT_4TMC	674..873	CDD:465056	66/257 (26%)
tw	NP_569858.1	PMT	44..290	CDD:396786	84/254 (33%)
		beta-trefoil_MIR_POMT2	321..503	CDD:467753	69/200 (35%)
		PMT_4TMC	520..761	CDD:465056	66/257 (26%)