DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rt and POMT2

DIOPT Version :9

Sequence 1:	NP_524025.2	Gene:	rt / 39297	FlyBaseID:	FBgn0003292	Length:	886	Species:	Drosophila melanogaster
Sequence 2:	XP_011534977.1	Gene:	POMT2 / 29954	HGNCID:	19743	Length:	813	Species:	Homo sapiens

Alignment Length:	845	Identity:	248/845 - (29%)
Similarity:	385/845 - (45%)	Gaps:	146/845 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   132 PSRSRSLSCQKQIDKNSAGAASAEERKTANASSQPFTVNLRIDLFSW-----TLFLLAFGTRFYK 191
            |.|.|   |..|..:.:....:||  ..|.:..:|...:.|.:...|     .:.||:|.|||::
Human    16 PRRGR---CGPQAARAAGRDVAAE--AVARSPKRPAWGSRRFEAVGWWALLALVTLLSFATRFHR 75

  Fly   192 LATPPHIVFDELHYGKYISMYMRNIFFFDQHPPLGKQLIAGLVSLAGYDGNYTFTRIGEPYSPEM 256
            |..||||.:||.|:||..|.|:...||||.||||||.||.....|:||||.:.|.:.|:.|. ..
Human    76 LDEPPHICWDETHFGKMGSYYINRTFFFDVHPPLGKMLIGLAGYLSGYDGTFLFQKPGDKYE-HH 139

  Fly   257 PIFWFRFLPAMCGSLLAPAVYNLLLEAKLSRWSSALGGLLVVLDNSLLTQSRFVLMESMLLLATT 321
            .....|...|..||.|.|..|..:|:...|..::.|...|:..|...||.|:::|::.:|:....
Human   140 SYMGMRGFCAFLGSWLVPFAYLTVLDLSKSLSAALLTAALLTFDTGCLTLSQYILLDPILMFFIM 204

  Fly   322 VGIACLLRFQ--RSRLGSLEWFFTGTAAAVCLGAAGTVKYVG-FLALGLAFYLLCRHLWQLLYDA 383
            ..:..::::.  ..|..|..|:|..:...|.|..|..||:|| |:.|.:....:. .||.|..|.
Human   205 AAMLSMVKYNSCADRPFSAPWWFWLSLTGVSLAGALGVKFVGLFIILQVGLNTIA-DLWYLFGDL 268

  Fly   384 GLTDRQLWMHAISRLLIFVGIPLAVYLGVFYIHFKTLHRAGPHDSIMTSAFQASLDGG---LASI 445
            .|:...:..|..:|:|..:.:|||:|...|.:||..|.::||.|...:|||||.|.|.   .|||
Human   269 SLSLVTVGKHLTARVLCLIVLPLALYTATFAVHFMVLSKSGPGDGFFSSAFQARLSGNNLHNASI 333

  Fly   446 TKGQPLAVVHGSQITLRHTHGRTCWLHSHAAVYPVRYPDKRG-SSHQQQVTCYSFKDVNNWWLVK 509
                |..:.:||.||:::......:||||..:||      .| .:.|||||.|..||.||.|::|
Human   334 ----PEHLAYGSVITVKNLRMAIGYLHSHRHLYP------EGIGARQQQVTTYLHKDYNNLWIIK 388

  Fly   510 RPTKENLVVGDEP-------DIIRHGEIIQLVHGITSRALNSHDVAAAMTPQCQEVSCYIDYEIK 567
               |.|  ...:|       :.:|||:||:|.|..|||.|:||...|.||.:..:|:   .|.|.
Human   389 ---KHN--TNSDPLDPSFPVEFVRHGDIIRLEHKETSRNLHSHYHEAPMTRKHYQVT---GYGIN 445

  Fly   568 MAGEL--LWRVEILNRDSEGDIWHAIKSEVRLVHVSTEASLKFSGRQLPEWGFNQHEVVADREKA 630
            ..|:.  .||:|::|| ..|:....::|.:|.:|:.|...|..||:.||:||:.|.||.......
Human   446 GTGDSNDFWRIEVVNR-KFGNRIKVLRSRIRFIHLVTGCVLGSSGKVLPKWGWEQLEVTCTPYLK 509

  Fly   631 IHEDAIWNVEEHRYTQTEDHRERERQMLTAEMIPTKRTRISFWAKLLELQSKMLFQTKSV--PNH 693
            ...::||||        |||...:...::.:::     :.||...|||....|:.....:  .::
Human   510 ETLNSIWNV--------EDHINPKLPNISLDVL-----QPSFPEILLESHMVMIRGNSGLKPKDN 561

  Fly   694 MYSSMPHEWPLMDKGIAYWLDSQSSAQIYLLGNILLWYTATMGILVY--AGLLAFYAMRR-QRLC 755
            .::|.|..||:..:|:.:...:.:..::|||||.::|:...:.|.:|  :|.:...||:| .||.
Human   562 EFTSKPWHWPINYQGLRFSGVNDTDFRVYLLGNPVVWWLNLLSIALYLLSGSIIAVAMQRGARLP 626

  Fly   756 FDISEQ--------EW------------------------------------------------- 763
            .:::.|        .|
Human   627 AEVAGQVLWALPPLTWRQQGTCTPGEGRLPADGPSFAFTTPHLPLSFAFERKPRNHEIKKLAPGH 691

  Fly   764 -----QRFVLAGDTFFMGYVMHYIPYFCVDRTLFLHNYLPAFVFKLLLLCFVVEHLDYLLRRFCT 823
                 |..:..|....:|:.:||.|:|.:.|.|:.|:|.||.:|..:|...:   .|.|||....
Human   692 TARLSQVLLRGGGQVLLGWTLHYFPFFLMGRVLYFHHYFPAMLFSSMLTGIL---WDTLLRLCAW 753

  Fly   824 G-------RGVHLVRLYRLMLILWLVGVLSIFSKFIPFSYGARKMTLNEVRS----LRWKDTWDF 877
            |       ||:|:..:..|:|     |....|..|.|.:||.......:.:|    |||.|:|||
Human   754 GLASWPLARGIHVAGILSLLL-----GTAYSFYLFHPLAYGMVGPLAQDPQSPMAGLRWLDSWDF 813

Fly 878 877
Human 814 813

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rt	NP_524025.2	PMT	178..421	CDD:280519	84/250 (34%)
		PMT1	180..877	CDD:224839	235/790 (30%)
		MIR	452..508	CDD:197746	22/56 (39%)
		MIR	522..578	CDD:197746	23/64 (36%)
		MIR	586..642	CDD:197746	18/55 (33%)
		PMT_4TMC	672..875	CDD:292810	62/280 (22%)
POMT2	XP_011534977.1	PMT1	50..813	CDD:224839	237/804 (29%)
		PMT	62..306	CDD:280519	83/245 (34%)
		MIR	334..390	CDD:197746	24/64 (38%)
		MIR	404..459	CDD:197746	23/57 (40%)
		MIR	472..521	CDD:197746	19/56 (34%)
		PMT_4TMC	538..811	CDD:292810	62/280 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1928
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D101190at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820