DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rt and ogm1

DIOPT Version :9

Sequence 1:	NP_524025.2	Gene:	rt / 39297	FlyBaseID:	FBgn0003292	Length:	886	Species:	Drosophila melanogaster
Sequence 2:	NP_593237.1	Gene:	ogm1 / 2541418	PomBaseID:	SPAC22A12.07c	Length:	893	Species:	Schizosaccharomyces pombe

Alignment Length:	742	Identity:	184/742 - (24%)
Similarity:	330/742 - (44%)	Gaps:	99/742 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   180 LFLLAFGTRFYKLATPPHIVFDELHYGKYISMYMRNIFFFDQHPPLGKQLIAGLVSLAG--YDGN 242
            |.::||..|..:|..|..:||:||.|..|...|:.|....|.:|||||.|.:.:.:|.|  |:.|
pombe    40 LTVVAFCVRAQRLMNPAKVVFEELRYYNYAVDYVNNKLLMDVYPPLGKLLFSLVAALTGNKYELN 104

  Fly   243 YTFTRIGEPYSPEMPIFWFRFLPAMCGSLLAPAVYNLLLEAKLSRWSSALGGLLVVLDNSLLTQS 307
             |....|:.|......:..|....:.||||.|.:|..:.....|:.:::|..|.|:.||.|:|.|
pombe   105 -TLDEPGQQYPFTDVAYSMRLFTCLLGSLLVPLMYGTVYFPTKSKTAASLAALFVIFDNGLITMS 168

  Fly   308 RFVLME--SMLLLATTVGIACLLRFQRSRLGSLEWFFTGTAAAVCLGAAGTVKYVGFLALGLAFY 370
            |::::|  ::..::.|.....:...|:.|..||.|..:..:..|.||.|.:.|.......|....
pombe   169 RYIMIEIPALYFMSLTAFYWSVYEAQQKRPFSLRWHTSLLSTGVALGLALSTKLSAMFTFGWLLI 233

  Fly   371 LLCRHLWQLLYDAGLTDRQLWMHAISRLLIFVGIPLAVYLGVFYIHFKTLHRAGPHDSIMTSAFQ 435
            |...|||.||.|..:...::..|..|.:...:|:|:.|||.||.:|....::|...|:.:....:
pombe   234 LAAFHLWNLLGDLSVPMYRIVKHLFSYIFYLIGVPITVYLAVFAVHSHIAYKASVADAFLPPEHR 298

  Fly   436 ASLDGGLASITKGQPLAVVHGSQITLRHT---HGRTCWLHSHAAVYPVRYPDKRGSSHQQQVTCY 497
            .:|.|....   .|...|.:||.:|:|:.   ||   :|||...:||       ..:.||.::..
pombe   299 HALAGNRFD---DQFADVAYGSLVTIRNAIPEHG---YLHSSELLYP-------EGTEQQIISLV 350

  Fly   498 SFKDVNNWWLVKRP-----TKENLVVGDEPDIIRHGEIIQLVHGITSRALNSHDVAAAMTPQ--C 555
            ...:.|..|:::..     .:.|:      ::::.|.:::|.|.:|.|||:||:....::..  .
pombe   351 DEPNQNALWIIEHEHSQDNNRSNI------ELLKDGSVVRLRHVMTGRALHSHEHKPIVSNNDWQ 409

  Fly   556 QEVSCYIDYEIKMAGELLWRVEILNRDSEGDIWHA--------IKSEVRLVHVSTEASLKFSGRQ 612
            .|.|.|..:..:.....|:|::||.:.|:    ||        :.::.||:||.....|..|.|:
pombe   410 LEASAYGGFGFEGDANDLFRIQILEKKSK----HATSNGTVETLNTKFRLIHVFANCELMSSHRR 470

  Fly   613 LPEWGFNQHEVVADREKAIHEDAIWNVEEHRYTQTEDHRERERQMLTAEMIPTKRTRIS-----F 672
            .|:||..|.||...| ..:.....|.:|.:.:                :.:|:...:|:     |
pombe   471 FPDWGDYQREVTCCR-NCVERSTTWFIESNYH----------------DGLPSDSRKITYRKPGF 518

  Fly   673 WAKLLELQSKM-LFQTKSVPNHMYSSMPHEWPLMDKGIAYWLDSQSSAQIYLLGNILLWYTATMG 736
            ....:|....| |...|....|:|.|....|||:...:.::.:..  .|::.:||..:|| :.:.
pombe   519 LESFVEHNKLMWLKDRKMGDGHVYESSALTWPLLLGPLRFFYEQH--LQVFFMGNPFVWY-SVIS 580

  Fly   737 ILVYAGLLAFYAMRRQRLCF-DISEQEWQ------RFVLAGDTFFMGYVMHYIPYFCVDRTLFLH 794
            ::.:..::..:.:.|..|.: |.....:.      :||:|       :::|:.||......:||:
pombe   581 LVAFFVIVQIFCLARWNLGYNDFGPSAFHYNYNIGKFVVA-------WLLHWAPYILETDRVFLY 638

  Fly   795 NYLPAFVFKLLLLCFVVEHLDYLLRRFCTGRGVHLVR-LYRLMLILWLVGVLSIFSKFIPFSYGA 858
            :||||..|.:..|......|         |..|...| .|:.:.::.:..:..::..:.||:| .
pombe   639 HYLPALYFGIAALGVSWSFL---------GNAVFGNRTAYKALSVIIMALMFLVYRLYSPFTY-M 693

  Fly   859 RKMTLNEVRSLRWKDTWDFVLHKNHHL 885
            ..:|.:..|:|..|.:|:|  |.|.:|
pombe   694 TTLTKSSCRALELKGSWNF--HCNTYL 718

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rt	NP_524025.2	PMT	178..421	CDD:280519	75/244 (31%)
		PMT1	180..877	CDD:224839	180/732 (25%)
		MIR	452..508	CDD:197746	16/58 (28%)
		MIR	522..578	CDD:197746	14/57 (25%)
		MIR	586..642	CDD:197746	18/63 (29%)
		PMT_4TMC	672..875	CDD:292810	45/211 (21%)
ogm1	NP_593237.1	PMT1	11..716	CDD:224839	182/738 (25%)
		PMT	38..284	CDD:280519	75/244 (31%)
		MIR	312..363	CDD:197746	16/60 (27%)
		MIR	374..432	CDD:197746	14/63 (22%)
		MIR	444..499	CDD:197746	16/55 (29%)
		PMT_4TMC	518..710	CDD:292810	45/211 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1928
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10050
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	4	3.870