DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rt and ogm4

DIOPT Version :9

Sequence 1:	NP_524025.2	Gene:	rt / 39297	FlyBaseID:	FBgn0003292	Length:	886	Species:	Drosophila melanogaster
Sequence 2:	NP_596807.1	Gene:	ogm4 / 2539761	PomBaseID:	SPBC16C6.09	Length:	778	Species:	Schizosaccharomyces pombe

Alignment Length:	820	Identity:	245/820 - (29%)
Similarity:	398/820 - (48%)	Gaps:	110/820 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   122 RSRSLSRSPSPSRSRSLSCQKQIDKNSAGAASAEERKTANASSQPFTVNL------RIDLFSWTL 180
            :::.||:.||...:.:.|......|          :|:.|::.:..::||      :..|....:
pombe    11 KAQKLSKEPSVELTDTKSSDNVTPK----------QKSPNSTEEDVSLNLKTLKAKKFKLAFVLI 65

  Fly   181 FLLAFGTRFYKLATPPHIVFDELHYGKYISMYMRNIFFFDQHPPLGKQLIAGLVSLAGYDGNYTF 245
            .:|:|.|||:.|..|..:||||:|:||:.|.|::..:|||.|||..|.|:|.:..||||||:|.|
pombe    66 TVLSFITRFWNLNLPGEVVFDEVHFGKFASYYLQGKYFFDLHPPFAKLLLALVAKLAGYDGHYLF 130

  Fly   246 TRIGEPYSPE-MPIFWFRFLPAMCGSLLAPAVYNLLLEAKLSRWSSALGGLLVVLDNSLLTQSRF 309
            ..||:.|... :|....|..||:..||:.|.|:.::.|:.....:..:...||:.||:.:|:.|.
pombe   131 DNIGDNYKDNGVPYVTIRAWPALLSSLVPPVVFLIMKESGYDLLACIVSSSLVLFDNAHVTEGRL 195

  Fly   310 VLMESMLLLATTVGIACLLRFQRSRLG--SLEW----FFTGTAAAVCLGAAGTVKYVG---FLAL 365
            :|:::.||.:....|.|.:||.:.|..  |..|    ||||    ..|....:.||||   ||::
pombe   196 ILLDATLLFSMVCAIYCYVRFFKLRHTPFSRPWWAWLFFTG----FFLSCTISTKYVGFFTFLSI 256

  Fly   366 GLAFYLLCRHLWQLLYD--AGLTDRQLWMHAISRLLIFVGIPLAVYLGVFYIHFKTLHRAGPHDS 428
            ||:   :|..|| .|:|  .|||..:.:.|.::|....:..|...:|..||:||..|..:||.||
pombe   257 GLS---VCLELW-YLWDIKTGLTVERFFQHFLARFFCLIFFPFLFFLFWFYMHFNILTISGPGDS 317

  Fly   429 IMTSAFQASLDGGLASITKGQPLAVVHGSQITLRHTHGRTCWLHSHAAVYPVRYPDKRGSSHQQQ 493
            .|:..||.:|...  .||....: :.:...:|::|. |...:||||...||:.|.|.|.||..||
pombe   318 FMSLEFQETLSDN--PITANSTI-LNYYDIVTIKHM-GTNAFLHSHPEKYPIPYDDGRISSGGQQ 378

  Fly   494 VTCYSFKDVNNWWLV------KRPTKENLVVGDEPDIIRHGEIIQLVHGITSRALNSHDVAAAMT 552
            ||.|.|.|.||:|::      ..|.:..|.|.     :::.:.|:|.|..|:..|.:||||:...
pombe   379 VTGYQFDDENNYWMILPADHYDPPIEAKLNVP-----VKNMDYIKLHHVGTNTDLMTHDVASPYH 438

  Fly   553 PQCQEVSC------------YIDYEIKMAGELLWRVEILNRDSEGDIWHAIKSEVRLVHVSTEAS 605
            |..:|.:.            |..:::.|:.         |.|.:..: :...|..:|:|..|..:
pombe   439 PTNEEFTTVSVDESAGKKHEYTLFQVVMSD---------NTDPQRPL-YTKASSFKLIHKLTHVA 493

  Fly   606 LKFSGRQLPEWGFNQHEVVADREKAIHEDAI-WNVEEHRYTQTEDHR-ERERQMLTAEMIPTKRT 668
            :....:.||:|.|.|.|:  :..|.|...:| |..::  ....:|.| ::|::      ||.|
pombe   494 MWSDPKPLPDWAFKQLEI--NGAKNIQTGSIFWTFDD--IIGLKDSRLKKEKK------IPKK-- 546

  Fly   669 RISFWAKLLELQSKMLFQTKSVPN-HMYSSMPHEWPLMDKGIAYWLDSQSSAQIYLLGNILLWYT 732
             :.||.|.||||..|..|...:.. |.|||.|.:|..:..|||:|..|:.:.|||||||.:.|:.
pombe   547 -LPFWKKYLELQLTMFRQNNMLTEFHPYSSNPSDWFTLHHGIAFWAKSEENKQIYLLGNPIGWWI 610

  Fly   733 ATMGILVYAGLLAFYAMRRQRLCFDISEQEWQRFVLAGDTFFMGYVMHYIPYFCVDRTLFLHNYL 797
            ....:|....:.|...:.|||....:.|.....|..:...|:|.||.||:|:|.:.|.||||:||
pombe   611 IAGTVLSTTVVAAAEILLRQRGIRTLPETVRNHFYRSTMFFYMTYVFHYLPFFIMGRQLFLHHYL 675

  Fly   798 PAFVFKLLLLCFVVE-------------------HLDYLLRRFCTGRGVHLVRLYRLMLILWLVG 843
            ||.:...||:...::                   .:|......|..:..|::.|...:|::::
pombe   676 PAHLAGSLLVGAFIQLACRKSFRSPVSAGVPIPKDVDEKGHSKCHRKYGHVIELICTLLLIFV-- 738

  Fly   844 VLSIFSKFIPFSYGARKMTLNEVRSLRWKDTWDFVLHKNH 883
            |:..|:.|.|.:||.:.::::|....:|.|:|.|...|.:
pombe   739 VIYCFTFFAPMTYGDKSLSVDEWTRRKWLDSWVFQYQKQN 778

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rt	NP_524025.2	PMT	178..421	CDD:280519	90/254 (35%)
		PMT1	180..877	CDD:224839	232/748 (31%)
		MIR	452..508	CDD:197746	24/55 (44%)
		MIR	522..578	CDD:197746	13/67 (19%)
		MIR	586..642	CDD:197746	14/56 (25%)
		PMT_4TMC	672..875	CDD:292810	68/222 (31%)
ogm4	NP_596807.1	PMT1	37..776	CDD:224839	238/780 (31%)
		PMT	63..310	CDD:280519	90/254 (35%)
		MIR	337..396	CDD:197746	24/60 (40%)
		PMT_4TMC	549..770	CDD:292810	68/222 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	112	1.000	Domainoid score	I1582
eggNOG	1	0.900	-	-		E1_COG1928
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H68548
Inparanoid	1	1.050	328	1.000	Inparanoid score	I527
OMA	1	1.010	-	-		QHG52050
OrthoFinder	1	1.000	-	-		FOG0006552
OrthoInspector	1	1.000	-	-		oto101831
orthoMCL	1	0.900	-	-		OOG6_105038
Panther	1	1.100	-	-	LDO	PTHR10050
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R940
SonicParanoid	1	1.000	-	-		X4786
TreeFam	1	0.960	-	-
	13	12.860