Protein Alignment rt and twisted

DIOPT Version :10

• Sequence 1: NP_524025.2
• Gene: rt / 39297
• FlyBaseID: FBgn0003292
• Length: 886
• Species: Drosophila melanogaster
• Sequence 2: XP_312249.6
• Gene: twisted / 1273287
• VectorBaseID: AGAMI1_000701
• Length: 733
• Species: Anopheles gambiae
• Alignment Length: 810
• Identity: 231/810 - (28%)
• Similarity: 377/810 - (46%)
• Gaps: 154/810 - (19%)

  Fly   134 RSRSLSCQKQIDKNSAGAASAEERKTANASSQPFTVNLRIDLFSWTLF----LLAFGTRFYKLAT 194
            ||.|....:.:.|.|:..:.|:|   .:..|:|.:       :.|.||    ||..|||||.:..
Mosquito    12 RSGSEQAAENVSKMSSRKSKADE---PSDKSEPKS-------WWWLLFGVILLLTIGTRFYNVTV 66

  Fly   195 PPHIVFDELHYGKYISMYMRNIFFFDQHPPLGKQLIAGLVSLAGYDGNYTFTRIGEPYS----PE 255
            |.|:.:||.|:||..|.|:...||||.||||||.||.....|.||||.|.|.:.|:.|:    ..
Mosquito    67 PDHVCWDETHFGKMGSWYINRTFFFDVHPPLGKMLIGLSGYLTGYDGTYPFDKPGDKYNGTHYEG 131

  Fly   256 MPIFWFRFLPAMC---GSLLAPAVYNLLLEAKLSRWSSALGGLLVVLDNSLLTQSRFVLMESMLL 317
            |.||        |   |:.:.|..::.:.:...|..:|......::.|..:|..:|::|::..|:
Mosquito   132 MRIF--------CTALGAAVVPMSFHTVWDMTGSLTASTFAAAYILFDIGMLILNRYILLDPPLI 188

  Fly   318 L---ATTVGIACLLRFQRSRLG-SLEWF----FTGTAAAVCLGAAGTVKYVGFLALGLAFYLLCR 374
            .   |:.:|:|.:.|..|.... :..|:    |||...|..:    :||:||...:.|.......
Mosquito   189 FFMTASVMGMARVSRLTREAASFTRAWWVWLAFTGAMLACTI----SVKFVGLFVVLLVGLHTAS 249

  Fly   375 HLWQLLYDAGL----TDRQLWMHAISRLLIFVGIPLAVYLGVFYIHFKTLHRAGPHDSIMTSAFQ 435
            .||.:|.|..|    |.|||...|::.::    :|:.:|...||||...|:|:|..|...:|.||
Mosquito   250 DLWDVLGDLSLPITHTVRQLAARAVTLIV----LPVLLYASFFYIHLAVLNRSGSGDGFYSSGFQ 310

  Fly   436 ASLDG-GLASITKGQPLAVVHGSQITLRHTHGRTCWLHSHAAVYPVRYPDKRGSSHQQQVTCYSF 499
            ::|.| .|.:::  .|..|.:|:.:||::......:||||..:||     |...:.|||||.||.
Mosquito   311 SNLVGNSLYNVS--MPRQVAYGAVVTLKNHKTGGGYLHSHNHLYP-----KGFGARQQQVTTYSH 368

  Fly   500 KDVNNWWLVK---RPTKENLVVGDEPDIIRHGEIIQLVHGITSRALNSHDVAAAMTPQCQEVSCY 561
            ||.||.||:|   :.|.||:.      :||||::::|.|..|.|.|:||.....:|.:..:|:||
Mosquito   369 KDENNRWLIKPYDKQTVENVT------LIRHGDLVRLEHVQTRRNLHSHREQGPVTKKHLQVTCY 427

  Fly   562 IDYEIKMAGEL-------LWRVEILNRDSEGDIWHAIKSEVRLVHVSTEASLKFSGRQLPEWGFN 619
                    ||.       :|.|:|:. ...|.:...:.|.:...|......|..:.:|||:|||.
Mosquito   428 --------GEEGQGDTNDVWMVQIVG-GKAGQVVETVTSRLTFYHYIERCVLTTTNKQLPKWGFE 483

  Fly   620 QHEVVAD---REKAIHEDAIWNVEEHRYTQTEDHRERERQMLTAEMIPTKRTRI---SFWAKLLE 678
            |.||..:   |:||    |.||||::::                :.:|:...::   .|.::..|
Mosquito   484 QQEVTCNPNIRDKA----AQWNVEDNQF----------------DKLPSVNFQVYAPGFISRFFE 528

  Fly   679 LQSKMLFQTKSV-PNH-MYSSMPHEWPLMDKGIAYWLDSQSSAQIYLLGNILLWYTATMGILVYA 741
            ..:.||.....: |.. ..:|.|.:||:..:|..:   |.|..::|||||.::|::..:.:.::.
Mosquito   529 SHAVMLQGNAGLKPKEGEVTSRPWQWPINYRGQFF---SGSDHRVYLLGNPIIWWSNLVFLALFL 590

  Fly   742 GLLAFYAMRRQ-----------RLC-----FDISEQEWQRFVLAGDTFFMGYVMHYIPYFCVDRT 790
            .:.....:|.|           |.|     .|.:  :| :.:.|....|.|:::||:|::.:.|.
Mosquito   591 IIFGVEIIRYQRNSAASPPDTARTCPAPPAADAT--KW-KLLRAAVWLFGGWLIHYLPFYAMGRV 652

  Fly   791 LFLHNYLPAFVFKLLL----LCFVVEHLDYLLRRFCTGRGVHLVRLYRLMLILWLVGVLSIFSKF 851
            |:.|:|.||.||..:|    |.::...|...||..|.|..              :.|::..|..|
Mosquito   653 LYFHHYFPALVFNSMLAGVMLDYITGRLPGWLRHACLGTA--------------MAGLVYSFVLF 703

  Fly   852 IPFSYGARKMTLNE----VRSLRWKDTWDF 877
            .|.:||......:|    :.||:|..:|:|
Mosquito   704 SPLAYGMSGPFSHEPNSTLASLKWLSSWEF 733

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
rt	NP_524025.2	PMT	178..421	CDD:396786	84/265 (32%)
		beta-trefoil_MIR_POMT1	453..644	CDD:467752	69/203 (34%)
		PMT_4TMC	674..873	CDD:465056	54/224 (24%)
twisted	XP_312249.6	None