DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fum3 and Fum4

DIOPT Version :9

Sequence 1:	NP_001261710.1	Gene:	Fum3 / 39281	FlyBaseID:	FBgn0036162	Length:	470	Species:	Drosophila melanogaster
Sequence 2:	NP_723527.1	Gene:	Fum4 / 318995	FlyBaseID:	FBgn0051874	Length:	484	Species:	Drosophila melanogaster

Alignment Length:	462	Identity:	299/462 - (64%)
Similarity:	372/462 - (80%)	Gaps:	0/462 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 ETRQESDTLGPMEVPMDRYYGAQTMRCLINFRIGGEEERMPRQIIQAMGILKKAAAETNQEFGLD 72
            :||.|.|::|.:.:|:||.:|.||||.|:.|.|||.||||||.:|:|:||:||:|||||:...|:
  Fly    22 DTRVEYDSMGAVHIPLDRMFGPQTMRSLMKFPIGGVEERMPRPLIKALGIVKKSAAETNKIHCLE 86

  Fly    73 PKLSTAISNAADDVISGKLYDEGHFPLPIWQTGSGTQSNMNSNEVIGNRAIELLGGRIGTKDPVH 137
            ..|..|||.|.|||||||||||.||||.|||.|||..:|||.||||.|||||:|||::|:|:||.
  Fly    87 EHLCDAISKACDDVISGKLYDEEHFPLVIWQDGSGEHTNMNVNEVICNRAIEILGGQMGSKEPVD 151

  Fly   138 PNDHVNKSQSSNDTFPSAIHIAVATALTKDLRPAVTALRDSLQAKSNEWKDIIKIGRTHTQDAVP 202
            ||:|||.:|||:|||.:|:.||||..|.:.|.|::....|.|..|||:|.|:|||||||..||||
  Fly   152 PNEHVNMAQSSHDTFSTAVRIAVAMQLQETLYPSLRTFIDLLGKKSNDWMDLIKIGRTHLMDAVP 216

  Fly   203 LTLGQEFSGYAQQLTNGLQRIDAVLPRVYQLALGGTAVGTGLNTRRGFAEKCVKRIAQLSGLPFV 267
            |:||||||||.|||.||..|:|..:.|:|||.:|||:|||.::|:..::.:|:||||:|:.||||
  Fly   217 LSLGQEFSGYQQQLVNGRTRLDCAMCRLYQLPMGGTSVGTKVDTKAEYSAQCIKRIAELTFLPFV 281

  Fly   268 VAPNFFEALACRDAMVEVHGALNVLAVSLMKVTNDIRFLGSGPRCGLGELFLPENEPGSSIMPGK 332
            .:|||||:::..|.:||:||.||.:|.|:||:.|||||||||||||.|||.||||||||||||||
  Fly   282 ESPNFFESISACDCLVELHGELNTIAASVMKIANDIRFLGSGPRCGFGELHLPENEPGSSIMPGK 346

  Fly   333 VNPTQCEAMTMICAQVMGNHVAVSVGGANGHFELNVFKPLIASNVLRSIKLLADGCISFNCNCVK 397
            |||||||||:||||||||||||||:||::|||:||.|.|:|||||||||.||.||..||..||::
  Fly   347 VNPTQCEAMSMICAQVMGNHVAVSMGGSSGHFQLNTFMPMIASNVLRSITLLGDGMKSFCTNCLE 411

  Fly   398 GIKPNKEKLAKIVNESLMLVTALNPHIGYDKSAQIAKAAHKNGTTLKVEALNAGISEKDFNEWVR 462
            ||:||:.|:..||.|||||||||:|||||::||.||||||.|||||:.||:..||..:||.|||:
  Fly   412 GIEPNRSKIGSIVKESLMLVTALSPHIGYERSAAIAKAAHHNGTTLEQEAILDGIQREDFREWVQ 476

  Fly   463 PEKMLGP 469
            |.|||||
  Fly   477 PSKMLGP 483

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fum3	NP_001261710.1	fumC	8..469	CDD:234779	297/460 (65%)
Fum3	NP_001261710.1	Fumarase_classII	10..466	CDD:176465	293/455 (64%)
Fum4	NP_723527.1	fumC	22..483	CDD:234779	297/460 (65%)
Fum4	NP_723527.1	Fumarase_classII	24..480	CDD:176465	293/455 (64%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45471476
Domainoid	1	1.000	390	1.000	Domainoid score	I15
eggNOG	1	0.900	-	-		E1_COG0114
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	559	1.000	Inparanoid score	I15
Isobase	1	0.950	-	0	Normalized mean entropy	S145
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1022919at2759
OrthoFinder	1	1.000	-	-		FOG0002459
OrthoInspector	1	1.000	-	-		otm51349
orthoMCL	1	0.900	-	-		OOG6_101016
Panther	1	1.100	-	-	P	PTHR11444
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1641
	12	11.750