DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fum3 and FH

DIOPT Version :9

Sequence 1:	NP_001261710.1	Gene:	Fum3 / 39281	FlyBaseID:	FBgn0036162	Length:	470	Species:	Drosophila melanogaster
Sequence 2:	NP_000134.2	Gene:	FH / 2271	HGNCID:	3700	Length:	510	Species:	Homo sapiens

Alignment Length:	461	Identity:	314/461 - (68%)
Similarity:	374/461 - (81%)	Gaps:	3/461 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 RQESDTLGPMEVPMDRYYGAQTMRCLINFRIGGEEERMPRQIIQAMGILKKAAAETNQEFGLDPK 74
            |.|.||.|.::||.|:||||||:|..:||:|||..||||..:|:|.||||:||||.||::|||||
Human    51 RIEYDTFGELKVPNDKYYGAQTVRSTMNFKIGGVTERMPTPVIKAFGILKRAAAEVNQDYGLDPK 115

  Fly    75 LSTAISNAADDVISGKLYDEGHFPLPIWQTGSGTQSNMNSNEVIGNRAIELLGGRIGTKDPVHPN 139
            ::.||..|||:|..|||.|  ||||.:||||||||:|||.||||.|||||:|||.:|:|.|||||
Human   116 IANAIMKAADEVAEGKLND--HFPLVVWQTGSGTQTNMNVNEVISNRAIEMLGGELGSKIPVHPN 178

  Fly   140 DHVNKSQSSNDTFPSAIHIAVATALTKDLRPAVTALRDSLQAKSNEWKDIIKIGRTHTQDAVPLT 204
            ||||||||||||||:|:|||.|..:.:.|.|.:..|.|:|.|||.|:..||||||||||||||||
Human   179 DHVNKSQSSNDTFPTAMHIAAAIEVHEVLLPGLQKLHDALDAKSKEFAQIIKIGRTHTQDAVPLT 243

  Fly   205 LGQEFSGYAQQLTNGLQRIDAVLPRVYQLALGGTAVGTGLNTRRGFAEKCVKRIAQLSGLPFVVA 269
            ||||||||.||:...:.||.|.:||:|:||.||||||||||||.|||||...::|.|:|||||.|
Human   244 LGQEFSGYVQQVKYAMTRIKAAMPRIYELAAGGTAVGTGLNTRIGFAEKVAAKVAALTGLPFVTA 308

  Fly   270 PNFFEALACRDAMVEVHGALNVLAVSLMKVTNDIRFLGSGPRCGLGELFLPENEPGSSIMPGKVN 334
            ||.|||||..||:||:.||:|..|.||||:.|||||||||||.|||||.||||||||||||||||
Human   309 PNKFEALAAHDALVELSGAMNTTACSLMKIANDIRFLGSGPRSGLGELILPENEPGSSIMPGKVN 373

  Fly   335 PTQCEAMTMICAQVMGNHVAVSVGGANGHFELNVFKPLIASNVLRSIKLLADGCISFNCNCVKGI 399
            |||||||||:.||||||||||:|||:|||||||||||::..|||.|.:||.|..:||..|||.||
Human   374 PTQCEAMTMVAAQVMGNHVAVTVGGSNGHFELNVFKPMMIKNVLHSARLLGDASVSFTENCVVGI 438

  Fly   400 KPNKEKLAKIVNESLMLVTALNPHIGYDKSAQIAKAAHKNGTTLKVEALNAG-ISEKDFNEWVRP 463
            :.|.|::.|::||||||||||||||||||:|:|||.|||||:|||..|:..| ::.:.|:|||:|
Human   439 QANTERINKLMNESLMLVTALNPHIGYDKAAKIAKTAHKNGSTLKETAIELGYLTAEQFDEWVKP 503

  Fly   464 EKMLGP 469
            :.||||
Human   504 KDMLGP 509

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fum3	NP_001261710.1	fumC	8..469	CDD:234779	312/459 (68%)
Fum3	NP_001261710.1	Fumarase_classII	10..466	CDD:176465	310/456 (68%)
FH	NP_000134.2	fumC	49..510	CDD:234779	314/461 (68%)
		Substrate binding. /evidence=ECO:0000250\|UniProtKB:P05042	145..147		1/1 (100%)
		Substrate binding (B site). /evidence=ECO:0000250\|UniProtKB:P05042	176..179		2/2 (100%)
		Substrate binding. /evidence=ECO:0000250\|UniProtKB:P05042	186..188		1/1 (100%)
		Substrate binding. /evidence=ECO:0000250\|UniProtKB:P9WN93	371..373		1/1 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159912
Domainoid	1	1.000	520	1.000	Domainoid score	I305
eggNOG	1	0.900	-	-		E1_COG0114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S145
OMA	1	1.010	-	-		QHG61095
OrthoDB	1	1.010	-	-		D1022919at2759
OrthoFinder	1	1.000	-	-		FOG0002459
OrthoInspector	1	1.000	-	-		otm40526
orthoMCL	1	0.900	-	-		OOG6_101016
Panther	1	1.100	-	-	O	PTHR11444
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1641
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.670