DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fum3 and fum-1

DIOPT Version :9

Sequence 1:	NP_001261710.1	Gene:	Fum3 / 39281	FlyBaseID:	FBgn0036162	Length:	470	Species:	Drosophila melanogaster
Sequence 2:	NP_498642.1	Gene:	fum-1 / 176059	WormBaseID:	WBGene00001503	Length:	501	Species:	Caenorhabditis elegans

Alignment Length:	461	Identity:	327/461 - (70%)
Similarity:	376/461 - (81%)	Gaps:	3/461 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 RQESDTLGPMEVPMDRYYGAQTMRCLINFRIGGEEERMPRQIIQAMGILKKAAAETNQEFGLDPK 74
            |:|.||.|.:|||.|:||||||.|..:||:|||.|||||..:|.|.||||||||..|.|||||.|
Worm    42 RKERDTFGELEVPADKYYGAQTARSQMNFKIGGPEERMPIPVIHAFGILKKAAALVNTEFGLDKK 106

  Fly    75 LSTAISNAADDVISGKLYDEGHFPLPIWQTGSGTQSNMNSNEVIGNRAIELLGGRIGTKDPVHPN 139
            |:.|||.|||:|:.||| || ||||..||||||||||||.||||.|||||:|||.:|:|.|||||
Worm   107 LADAISQAADEVVDGKL-DE-HFPLVTWQTGSGTQSNMNVNEVISNRAIEILGGELGSKKPVHPN 169

  Fly   140 DHVNKSQSSNDTFPSAIHIAVATALTKDLRPAVTALRDSLQAKSNEWKDIIKIGRTHTQDAVPLT 204
            ||||.|||||||||:|:||||...:...|.||:..||.:|..|:.|:||||||||||||||||||
Worm   170 DHVNMSQSSNDTFPTAMHIAVGREVNSRLLPALKKLRTALHNKAEEFKDIIKIGRTHTQDAVPLT 234

  Fly   205 LGQEFSGYAQQLTNGLQRIDAVLPRVYQLALGGTAVGTGLNTRRGFAEKCVKRIAQLSGLPFVVA 269
            ||||||.|..||.|.:.|:::.|||:||||.||||||||||||:|||||....:::|:|||||.|
Worm   235 LGQEFSAYVTQLDNSIARVESTLPRLYQLAAGGTAVGTGLNTRKGFAEKVAATVSELTGLPFVTA 299

  Fly   270 PNFFEALACRDAMVEVHGALNVLAVSLMKVTNDIRFLGSGPRCGLGELFLPENEPGSSIMPGKVN 334
            ||.|||||..||:||||||||.:|||.||:.|||||||||||||||||.||||||||||||||||
Worm   300 PNKFEALAAHDALVEVHGALNTVAVSFMKIGNDIRFLGSGPRCGLGELSLPENEPGSSIMPGKVN 364

  Fly   335 PTQCEAMTMICAQVMGNHVAVSVGGANGHFELNVFKPLIASNVLRSIKLLADGCISFNCNCVKGI 399
            ||||||:||:.||||||.|||||||:|||||||||||||..|||:|.:||||..:||..:||.||
Worm   365 PTQCEAITMVAAQVMGNQVAVSVGGSNGHFELNVFKPLIVRNVLQSTRLLADSAVSFTDHCVDGI 429

  Fly   400 KPNKEKLAKIVNESLMLVTALNPHIGYDKSAQIAKAAHKNGTTLKVEALNAGI-SEKDFNEWVRP 463
            ..||:.:|||:.||||||||||||||||.:|:|||.||||||||..||:..|| :|:.|.:||:|
Worm   430 VANKDNIAKIMRESLMLVTALNPHIGYDNAAKIAKTAHKNGTTLVQEAVKLGILTEEQFAQWVKP 494

  Fly   464 EKMLGP 469
            |.||||
Worm   495 ENMLGP 500

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fum3	NP_001261710.1	fumC	8..469	CDD:234779	325/459 (71%)
Fum3	NP_001261710.1	Fumarase_classII	10..466	CDD:176465	323/456 (71%)
fum-1	NP_498642.1	fumC	38..501	CDD:234779	327/461 (71%)
fum-1	NP_498642.1	Fumarase_classII	42..497	CDD:176465	323/456 (71%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160167429
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S145
OMA	1	1.010	-	-		QHG61095
OrthoDB	1	1.010	-	-		D1022919at2759
OrthoFinder	1	1.000	-	-		FOG0002459
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101016
Panther	1	1.100	-	-	O	PTHR11444
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1641
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.810