DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fum3 and Fh1

DIOPT Version :9

Sequence 1:	NP_001261710.1	Gene:	Fum3 / 39281	FlyBaseID:	FBgn0036162	Length:	470	Species:	Drosophila melanogaster
Sequence 2:	NP_034339.2	Gene:	Fh1 / 14194	MGIID:	95530	Length:	507	Species:	Mus musculus

Alignment Length:	461	Identity:	316/461 - (68%)
Similarity:	375/461 - (81%)	Gaps:	3/461 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 RQESDTLGPMEVPMDRYYGAQTMRCLINFRIGGEEERMPRQIIQAMGILKKAAAETNQEFGLDPK 74
            |.|.||.|.::||.|:||||||:|..:||:|||..||||..:|||.||||:||||.|||:|||||
Mouse    48 RVEFDTFGELKVPTDKYYGAQTVRSTMNFKIGGATERMPIPVIQAFGILKRAAAEVNQEYGLDPK 112

  Fly    75 LSTAISNAADDVISGKLYDEGHFPLPIWQTGSGTQSNMNSNEVIGNRAIELLGGRIGTKDPVHPN 139
            :::||..|||:|..|||.|  ||||.:||||||||:|||.||||.|||||:|||.:|:|.|||||
Mouse   113 IASAIMKAADEVAEGKLND--HFPLVVWQTGSGTQTNMNVNEVISNRAIEMLGGELGSKKPVHPN 175

  Fly   140 DHVNKSQSSNDTFPSAIHIAVATALTKDLRPAVTALRDSLQAKSNEWKDIIKIGRTHTQDAVPLT 204
            ||||||||||||||:|:|||.|..:.|.|.|.:..|.|:|.|||.|:..:|||||||||||||||
Mouse   176 DHVNKSQSSNDTFPTAMHIAAAVEVHKVLLPGLQKLHDALSAKSKEFAQVIKIGRTHTQDAVPLT 240

  Fly   205 LGQEFSGYAQQLTNGLQRIDAVLPRVYQLALGGTAVGTGLNTRRGFAEKCVKRIAQLSGLPFVVA 269
            ||||||||.||:...:.||.|.:||:|:||.||||||||||||.|||||...::|.|:|||||.|
Mouse   241 LGQEFSGYVQQVQYAMVRIKAAMPRIYELAAGGTAVGTGLNTRIGFAEKVAAKVAALTGLPFVTA 305

  Fly   270 PNFFEALACRDAMVEVHGALNVLAVSLMKVTNDIRFLGSGPRCGLGELFLPENEPGSSIMPGKVN 334
            ||.|||||..||:||:.||:|..|.||||:.|||||||||||.|||||.||||||||||||||||
Mouse   306 PNKFEALAAHDALVELSGAMNTAACSLMKIANDIRFLGSGPRSGLGELILPENEPGSSIMPGKVN 370

  Fly   335 PTQCEAMTMICAQVMGNHVAVSVGGANGHFELNVFKPLIASNVLRSIKLLADGCISFNCNCVKGI 399
            |||||||||:.||||||||||:|||:|||||||||||::..|||.|.:||.|..:||..|||.||
Mouse   371 PTQCEAMTMVAAQVMGNHVAVTVGGSNGHFELNVFKPMMIKNVLHSARLLGDASVSFTDNCVVGI 435

  Fly   400 KPNKEKLAKIVNESLMLVTALNPHIGYDKSAQIAKAAHKNGTTLKVEALNAG-ISEKDFNEWVRP 463
            :.|.|::.|::||||||||||||||||||:|:|||.|||||:|||..|:..| ::.:.|:|||:|
Mouse   436 QANTERINKLMNESLMLVTALNPHIGYDKAAKIAKTAHKNGSTLKETAIELGYLTAEQFDEWVKP 500

  Fly   464 EKMLGP 469
            :.||||
Mouse   501 KDMLGP 506

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fum3	NP_001261710.1	fumC	8..469	CDD:234779	314/459 (68%)
Fum3	NP_001261710.1	Fumarase_classII	10..466	CDD:176465	312/456 (68%)
Fh1	NP_034339.2	fumC	46..507	CDD:234779	316/461 (69%)
		Substrate binding. /evidence=ECO:0000250\|UniProtKB:P05042	142..144		1/1 (100%)
		Substrate binding (B site). /evidence=ECO:0000250\|UniProtKB:P05042	173..176		2/2 (100%)
		Substrate binding. /evidence=ECO:0000250\|UniProtKB:P05042	183..185		1/1 (100%)
		Substrate binding. /evidence=ECO:0000250\|UniProtKB:P9WN93	368..370		1/1 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167850282
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S145
OMA	1	1.010	-	-		QHG61095
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002459
OrthoInspector	1	1.000	-	-		otm42598
orthoMCL	1	0.900	-	-		OOG6_101016
Panther	1	1.100	-	-	O	PTHR11444
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1641
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	12	11.660