Protein Alignment CG7560 and MTHFR

DIOPT Version :10

• Sequence 1: NP_648462.1
• Gene: CG7560 / 39276
• FlyBaseID: FBgn0036157
• Length: 349
• Species: Drosophila melanogaster
• Sequence 2: NP_001317287.1
• Gene: MTHFR / 4524
• HGNCID: 7436
• Length: 697
• Species: Homo sapiens
• Alignment Length: 273
• Identity: 68/273 - (24%)
• Similarity: 128/273 - (46%)
• Gaps: 44/273 - (16%)

  Fly    79 PTFVSFVWLSQRYWDVEPVG------QVESLQMAQHLAT--RIPVLPHVSAYRMSRQRLDQFLA- 134
            |.::...|        .|.|      :..|:.:|.....  .:..:.|::.   .||||::...
Human   129 PLYIDVTW--------HPAGDPGSDKETSSMMIASTAVNYCGLETILHMTC---CRQRLEEITGH 182

  Fly   135 ------LNFSSLLAVRGDRV-----HEDQDFSISYPMVEQSIRQRGETISVCVGGYPEGYTSLGD 188
                  |...:::|:|||.:     .|:..|:.:..:|:....:.|:...:||.|||:|:...|.
Human   183 LHKAKQLGLKNIMALRGDPIGDQWEEEEGGFNYAVDLVKHIRSEFGDYFDICVAGYPKGHPEAGS 247

  Fly   189 IPQNSAKNMEFLKAKIDAGADCIITQLCYRPEVIVQFVKDCRAAGISVPIVVGLMSHESFRSYSM 253
            .    ..:::.||.|:.||||.|||||.:..:...:|||.|...||:.|||.|:...:.:.|...
Human   248 F----EADLKHLKEKVSAGADFIITQLFFEADTFFRFVKACTDMGITCPIVPGIFPIQGYHSLRQ 308

  Fly   254 IEQITGVHLPDDLREQLDQLHSAHMKDMKSDQDLIRRFFVSLTVRTIRNVLDADVGVWGFHFFTL 318
            :.:::.:.:|.::::.::.:        |.:...||.:.:.|.|...:.:|.:.: |.|.||:||
Human   309 LVKLSKLEVPQEIKDVIEPI--------KDNDAAIRNYGIELAVSLCQELLASGL-VPGLHFYTL 364

  Fly   319 NRFKSVQAVLQEL 331
            ||..:...||:.|
Human   365 NREMATTEVLKRL 377

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG7560	NP_648462.1	MTHFR	76..331	CDD:238299	67/271 (25%)
MTHFR	NP_001317287.1	MTHFR	101..667	CDD:444783	68/273 (25%)