DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11726 and EIF4H

DIOPT Version :9

Sequence 1:	NP_648461.1	Gene:	CG11726 / 39275	FlyBaseID:	FBgn0036156	Length:	291	Species:	Drosophila melanogaster
Sequence 2:	NP_071496.1	Gene:	EIF4H / 7458	HGNCID:	12741	Length:	248	Species:	Homo sapiens

Alignment Length:	192	Identity:	50/192 - (26%)
Similarity:	78/192 - (40%)	Gaps:	25/192 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    76 EEEVSMEPPFVALVSNLPMECTEGELRKVFTSFSIRSLTI--PKKGKRPKGFAYVEMDSREDLVR 138
            ::|:..|||:.|.|.|||....:|::..:|...||||:.:  .|...:.|||.|||.|..:.|..
Human    33 QKELPTEPPYTAYVGNLPFNTVQGDIDAIFKDLSIRSVRLVRDKDTDKFKGFCYVEFDEVDSLKE 97

  Fly   139 LLKMDKLKCRGRCLMAKIGQLPPEPPTKAAGDGFSLFTCSGRQFDINSSHYSA----SVSDLST- 198
            .|..|......|.|...|.:     ..|....||...........:.||..|.    |..|.::
Human    98 ALTYDGALLGDRSLRVDIAE-----GRKQDKGGFGFRKGGPDDRGMGSSRESRGGWDSRDDFNSG 157

  Fly   199 -IDSPISARNSPFPSESES-----SFFGRDNPIK------RIPSSTEEVER-RMQIRLQKLA 247
             .|..:..|....|.:..:     |.|....|::      |.|:..|..:| |:|::.:.:|
Human   158 FRDDFLGGRGGSRPGDRRTGPPMGSRFRDGPPLRGSNMDFREPTEEERAQRPRLQLKPRTVA 219

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11726	NP_648461.1	RRM_SF	84..156	CDD:302621	25/73 (34%)
EIF4H	NP_071496.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..41		2/7 (29%)
		RRM_eIF4H	37..120	CDD:409835	28/87 (32%)
		SF-CC1	<40..>227	CDD:273721	48/185 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	121..248		20/99 (20%)
		HHV-1 Vhs binding site	137..157		5/19 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1530583at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	3	2.880