DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7573 and ste24c

DIOPT Version :9

Sequence 1:	NP_729695.2	Gene:	CG7573 / 39272	FlyBaseID:	FBgn0036153	Length:	477	Species:	Drosophila melanogaster
Sequence 2:	NP_001027433.1	Gene:	ste24c / 3772676	FlyBaseID:	FBgn0050462	Length:	456	Species:	Drosophila melanogaster

Alignment Length:	440	Identity:	135/440 - (30%)
Similarity:	231/440 - (52%)	Gaps:	7/440 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 DPILLRHILCLVIVVHNSFHLILCCRQLKLCKRTSVPPKQMEGILSQEAFQASKDKQLHASSLEI 100
            |||::..:|||:::|...:.:||..||..:|....:.|:::.||:..|.:..::..:||.:.|:|
  Fly    11 DPIIVLVVLCLIVLVDRIWEMILTKRQQLVCLNAIMVPEELRGIIPPEIYHRARIYELHKTELQI 75

  Fly   101 FNIAIDTLYSCLDLYLCTLAFLWKLTVGWYHYADS--TWLNVTFMTVFSTYLVVRKLPSLFYEKL 163
            :...||.:.:..:|.|....|||.|:........|  .|:.:.|:...:.|:.:|.||.|.|:|.
  Fly    76 WKYLIDLIITLCELILGFYPFLWSLSAKTLQKITSQEIWITLIFVFYLTIYICIRFLPVLIYDKC 140

  Fly   164 VLDPRYNVDPEKTPPLLGLICALVFVVVFLQVAVIPLTAIFMAIHMLSEWYFTLFVWLGLVGLSV 228
            :|:.||.:. .|.|..| ..|.....::..|:.:.||.|..:.......:||.|:.||.....::
  Fly   141 LLELRYGMS-GKFPWYL-YCCIGAMSILLSQLVLFPLAAAIVFSVKFIGYYFFLWFWLFWATFTL 203

  Fly   229 LVLAFVGLFGVPCLGKSRKM-NSTDMDNSLKAVLDDFNFP-GRVYMVHTFHVGRPTAWVMGCCCC 291
            |::.|:....:||:|:...: ..|.:...:|.|.|...|| .||:::.|..:....|:..|.||.
  Fly   204 LLVFFLPYCCIPCIGRQVVLPEGTALYMEVKRVCDVVGFPMKRVFIIKTRTMQYSNAYFYGSCCL 268

  Fly   292 LRLDIHDNLKWNRGFSSDDFDWGQMGAGLNDEQLAAFVAHQLAHWQLWHVAKGLALIYFYLLIYL 356
            .|:.|.|.|..|:|...::....::|.||.:.|:|..|.|:|.||:..|..|...::..:..|.:
  Fly   269 KRIVIFDTLLLNKGKEPNEIHPYEVGRGLTNIQVAGVVCHELGHWKHGHFYKATIIMKIHFFITM 333

  Fly   357 LLFGICNRWITLYAAAGFTT-FYPSSVGFWLVYKYLMPIYHDISTWIVFFCIRHFEYAADAYVNR 420
            .|||:......||.|.||.. ..|..|||.:|.|:.:..|..::..::.:.:|.||||||.:.:|
  Fly   334 GLFGLFFHSPQLYMAVGFEPGVMPIIVGFIIVLKFALTPYLTLANVLMLWNLRRFEYAADKFAHR 398

  Fly   421 RGYGLPMRAALLKLFSDDYEFPYVDQCYLMWHRLRPSVLQRIDNLQRLNM 470
            .||.:.:|.||:|:::|...||..||||..||...|::|||:...|:|::
  Fly   399 MGYSIQLRMALVKIYADHMSFPVYDQCYARWHHTHPTILQRLAYQQKLDV 448

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7573	NP_729695.2	Peptidase_M48_N	62..240	CDD:293100	46/179 (26%)
CG7573	NP_729695.2	Peptidase_M48	<320..466	CDD:299867	53/146 (36%)
ste24c	NP_001027433.1	Peptidase_M48_N	37..215	CDD:293100	46/179 (26%)
		HtpX	131..452	CDD:223575	102/320 (32%)
		Peptidase_M48	229..441	CDD:299867	73/211 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45450186
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0501
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002450
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10120
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.840