DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7573 and Zmpste24

DIOPT Version :9

Sequence 1:	NP_729695.2	Gene:	CG7573 / 39272	FlyBaseID:	FBgn0036153	Length:	477	Species:	Drosophila melanogaster
Sequence 2:	XP_006503082.1	Gene:	Zmpste24 / 230709	MGIID:	1890508	Length:	494	Species:	Mus musculus

Alignment Length:	471	Identity:	97/471 - (20%)
Similarity:	199/471 - (42%)	Gaps:	80/471 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    58 LCCRQLKLCKRTSVPPKQMEGILSQEAFQASKDKQLHASSLEIFNIAIDTLYSCLD--------- 113
            |..||.::.|.|:..|.::|.|:..:.|:.|:..||..|:...::    .|||.::
Mouse    37 LAQRQRRIYKTTTRVPAELEQIMDSDTFEKSRLYQLDKSTFSFWS----GLYSEVEGTDSSFPDH 97

  Fly   114 --------------LYLCTLAFLWKL------TVGW---YHYADSTWLNVTFMTVFSTYLVVRKL 155
                          |....:.:||:|      :.|:   |....|    :.|:.:.:.:..:..|
Mouse    98 RRSESPILFHSLFILLFGGIPYLWRLSGQFCSSAGFGPEYEIIQS----LVFLLLATLFSALTGL 158

  Fly   156 PSLFYEKLVLDPRYNVDPEKTPPLLGLICALVFVV-------VFLQVAVIPLTAIFMAIHMLSEW 213
            |...|...|::.::..:.:          .|.|.:       :..|..::|::|:.:.|..:...
Mouse   159 PWSLYNTFVIEEKHGFNHQ----------TLEFFMKDAIKKFIVTQCILLPVSALLLYIIKIGGD 213

  Fly   214 YFTLFVWLGLVGLSVLVLAFVGLFGVPCLGKSRKMNSTDMDNSLKAVLDDFNFP-GRVYMVH-TF 276
            ||.::.||..:.:|::::.....:..|...|...:....:...::.:....:|| .:||:|. :.
Mouse   214 YFFIYAWLFTLVVSLVLVTIYADYIAPLFDKFTPLPEGKLKQEIEVMAKSIDFPLTKVYVVEGSK 278

  Fly   277 HVGRPTAWVMGCCCCLRLDIHDNL--------KWNRGFS------SDDFDWGQMGA-------GL 320
            ......|:..|.....|:.:.|.|        |.|:..|      ..:.|..::.|       |.
Mouse   279 RSSHSNAYFYGFFKNKRIVLFDTLLEEYSVPNKDNQEESGMEARNEGEGDSEEVKAKVKNKKQGC 343

  Fly   321 NDEQLAAFVAHQLAHWQLWHVAKGLALIYFYLLIYLLLFGICNRWITLYAAAGFTTFYPSSVGFW 385
            .:|::.|.:.|:|.||:|.|..|.:.:......:...||.:......|:||.||....|:.:|..
Mouse   344 KNEEVLAVLGHELGHWKLGHTVKNIIISQMNSFLCFFLFAVLIGRRELFAAFGFYDSQPTLIGLL 408

  Fly   386 LVYKYLMPIYHDISTWIVFFCIRHFEYAADAYVNRRGYGLPMRAALLKLFSDDYEFPYVDQCYLM 450
            ::::::...|:::.::.:....|.||:.|||:..:.|....:.:||:||..|:..||..|..:..
Mouse   409 IIFQFIFSPYNEVLSFCLTVLSRRFEFQADAFAKKLGKAKDLYSALIKLNKDNLGFPVSDWLFST 473

  Fly   451 WHRLRPSVLQRIDNLQ 466
            ||...|.:|:|:..|:
Mouse   474 WHYSHPPLLERLQALK 489

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7573	NP_729695.2	Peptidase_M48_N	62..240	CDD:293100	37/216 (17%)
CG7573	NP_729695.2	Peptidase_M48	<320..466	CDD:299867	39/145 (27%)
Zmpste24	XP_006503082.1	M48A_Zmpste24p_like	22..490	CDD:320702	97/471 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167838065
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0501
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S1184
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002450
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10120
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	7	6.750