Protein Alignment CG7573 and OMA1

DIOPT Version :10

• Sequence 1: NP_729695.2
• Gene: CG7573 / 39272
• FlyBaseID: FBgn0036153
• Length: 477
• Species: Drosophila melanogaster
• Sequence 2: NP_660286.1
• Gene: OMA1 / 115209
• HGNCID: 29661
• Length: 524
• Species: Homo sapiens
• Alignment Length: 478
• Identity: 82/478 - (17%)
• Similarity: 137/478 - (28%)
• Gaps: 218/478 - (45%)

  Fly   123 WKLTVGWYHY----------------ADSTWLNVTFMTV----FSTYLVVRK---LPSL------ 158
            |....|.:|:                :...|...:..||    ||..|::::   :|||
Human    61 WSFLPGNFHFYSTFNNKRTGGLSSTKSKEIWRITSKCTVWNDAFSRQLLIKEVTAVPSLSVLHPL 125

  Fly   159 ----------FYEKLVLDPRYNVDPEKTPPLLGLICALVFVVVFLQVAVIPLTAIFMAI--HMLS 211
                      |:    ..||:...|   .|||.:|             :.|:..:|..|  ..:.
Human   126 SPASIRAIRNFH----TSPRFQAAP---VPLLLMI-------------LKPVQKLFAIIVGRGIR 170

  Fly   212 EWY-------------------FTLFVWLGLVGLSVLVLAFVGLFGVPCLGKSRKM--------- 248
            :|:                   :.||:.|...||..:|..|..|...|..|:|:.:
Human   171 KWWQALPPNKKEVVKENIRKNKWKLFLGLSSFGLLFVVFYFTHLEVSPITGRSKLLLLGKEQFRL 235

  Fly   249 --------------NS--TDMDNSLKAV-------------------------------LDDFNF 266
                          |.  |:.|....||                               ::.|..
Human   236 LSELEYEAWMEEFKNDMLTEKDARYLAVKEVLCHLIECNKDVPGISQINWVIHVVDSPIINAFVL 300

  Fly   267 PGRVYMVHTFHVGRPTAWVMGCCCCLRLDIHDNLKWNRGFSSDDFDWGQMGAGLNDEQLAAFVAH 331
            |.....|.|..:...|            |||                          ||:..:.|
Human   301 PNGQMFVFTGFLNSVT------------DIH--------------------------QLSFLLGH 327

  Fly   332 QLAHWQLWHVAKGLALIY---FYLLIYL-LLFGICNRWITLYAAAGFTTFYPSSVGF---WLVYK 389
            ::||..|.|.|:...:::   |..:|:| :::.||.|               .|:..   |:..|
Human   328 EIAHAVLGHAAEKAGMVHLLDFLGMIFLTMIWAICPR---------------DSLALLCQWIQSK 377

  Fly   390 YLMPIYHDISTWIVFFCIRHFEYAADAYVNRRGYGLPMRAA----LLKLFSDDYEFPYVDQCYLM 450
            ....:::           |.:....:|..::.|..|..:|.    ...:|....||  ||..:..
Human   378 LQEYMFN-----------RPYSRKLEAEADKIGLLLAAKACADIRASSVFWQQMEF--VDSLHGQ 429

  Fly   451 -----WHRLRPSVLQRIDNLQRL 468
                 |....||...|::.|.||
Human   430 PKMPEWLSTHPSHGNRVEYLDRL 452

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG7573	NP_729695.2	Peptidase_M48_M56	42..467	CDD:333718	80/475 (17%)
OMA1	NP_660286.1	Cardiolipin-binding. /evidence=ECO:0000250|UniProtKB:Q9D8H7	148..167		7/31 (23%)
		Stress-sensor region. /evidence=ECO:0000250|UniProtKB:Q9D8H7	165..195		1/29 (3%)
		M48C_Oma1_like	263..456	CDD:320690	43/256 (17%)