Protein Alignment CG7573 and ZMPSTE24

DIOPT Version :10

• Sequence 1: NP_729695.2
• Gene: CG7573 / 39272
• FlyBaseID: FBgn0036153
• Length: 477
• Species: Drosophila melanogaster
• Sequence 2: NP_005848.2
• Gene: ZMPSTE24 / 10269
• HGNCID: 12877
• Length: 475
• Species: Homo sapiens
• Alignment Length: 442
• Identity: 95/442 - (21%)
• Similarity: 192/442 - (43%)
• Gaps: 37/442 - (8%)

  Fly    58 LCCRQLKLCKRTSVPPKQMEGILSQEAFQASKDKQLHASSLEIFNIAIDTLYSCLDLYLCTLAFL 122
            |..||.::.|.|:..|.::..|:..|.|:.|:..||..|:...::.........|.|....:.:|
Human    37 LAQRQRRIYKTTTHVPPELGQIMDSETFEKSRLYQLDKSTFSFWSGLYSETEGTLILLFGGIPYL 101

  Fly   123 WKLTVGWYHYAD-----STWLNVTFMTVFSTYLVVRKLPSLFYEKLVLDPRYNVDPEKTPPLLGL 182
            |:|:..:..||.     ....::.|:.:.:.:..:..||...|...|::.::..:.:    .||.
Human   102 WRLSGRFCGYAGFGPEYEITQSLVFLLLATLFSALTGLPWSLYNTFVIEEKHGFNQQ----TLGF 162

  Fly   183 I---CALVFVVVFLQVAVIPLTAIFMAIHMLSEWYFTLFVWLGLVGLSVLVLAFVGLFGVPCLGK 244
            .   ....|||.  |..::|::::.:.|..:...||.::.||..:.:|::::.....:..|...|
Human   163 FMKDAIKKFVVT--QCILLPVSSLLLYIIKIGGDYFFIYAWLFTLVVSLVLVTIYADYIAPLFDK 225

  Fly   245 SRKMNSTDMDNSLKAVLDDFNFP-GRVYMVH-TFHVGRPTAWVMGCCCCLRLDIHDNLKWNRGFS 307
            ...:....:...::.:....:|| .:||:|. :.......|:..|.....|:.:.|.|.......
Human   226 FTPLPEGKLKEEIEVMAKSIDFPLTKVYVVEGSKRSSHSNAYFYGFFKNKRIVLFDTLLEEYSVL 290

  Fly   308 SDDF--DWG-------------------QMGAGLNDEQLAAFVAHQLAHWQLWHVAKGLALIYFY 351
            :.|.  |.|                   ....|..:|::.|.:.|:|.||:|.|..|.:.:....
Human   291 NKDIQEDSGMEPRNEEEGNSEEIKAKVKNKKQGCKNEEVLAVLGHELGHWKLGHTVKNIIISQMN 355

  Fly   352 LLIYLLLFGICNRWITLYAAAGFTTFYPSSVGFWLVYKYLMPIYHDISTWIVFFCIRHFEYAADA 416
            ..:...||.:......|:||.||....|:.:|..::::::...|:::.::.:....|.||:.|||
Human   356 SFLCFFLFAVLIGRKELFAAFGFYDSQPTLIGLLIIFQFIFSPYNEVLSFCLTVLSRRFEFQADA 420

  Fly   417 YVNRRGYGLPMRAALLKLFSDDYEFPYVDQCYLMWHRLRPSVLQRIDNLQRL 468
            :..:.|....:.:||:||..|:..||..|..:.|||...|.:|:|:..|:.:
Human   421 FAKKLGKAKDLYSALIKLNKDNLGFPVSDWLFSMWHYSHPPLLERLQALKTM 472

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG7573	NP_729695.2	Peptidase_M48_M56	42..467	CDD:333718	95/439 (22%)
ZMPSTE24	NP_005848.2	M48A_Zmpste24p_like	22..470	CDD:320702	94/438 (21%)