Protein Alignment CG7573 and ZMPSTE24

DIOPT Version :9

• Sequence 1: NP_729695.2
• Gene: CG7573 / 39272
• FlyBaseID: FBgn0036153
• Length: 477
• Species: Drosophila melanogaster
• Sequence 2: NP_005848.2
• Gene: ZMPSTE24 / 10269
• HGNCID: 12877
• Length: 475
• Species: Homo sapiens
• Alignment Length: 442
• Identity: 95/442 - (21%)
• Similarity: 192/442 - (43%)
• Gaps: 37/442 - (8%)

  Fly    58 LCCRQLKLCKRTSVPPKQMEGILSQEAFQASKDKQLHASSLEIFNIAIDTLYSCLDLYLCTLAFL 122
            |..||.::.|.|:..|.::..|:..|.|:.|:..||..|:...::.........|.|....:.:|
Human    37 LAQRQRRIYKTTTHVPPELGQIMDSETFEKSRLYQLDKSTFSFWSGLYSETEGTLILLFGGIPYL 101

  Fly   123 WKLTVGWYHYAD-----STWLNVTFMTVFSTYLVVRKLPSLFYEKLVLDPRYNVDPEKTPPLLGL 182
            |:|:..:..||.     ....::.|:.:.:.:..:..||...|...|::.::..:.:    .||.
Human   102 WRLSGRFCGYAGFGPEYEITQSLVFLLLATLFSALTGLPWSLYNTFVIEEKHGFNQQ----TLGF 162

  Fly   183 I---CALVFVVVFLQVAVIPLTAIFMAIHMLSEWYFTLFVWLGLVGLSVLVLAFVGLFGVPCLGK 244
            .   ....|||.  |..::|::::.:.|..:...||.::.||..:.:|::::.....:..|...|
Human   163 FMKDAIKKFVVT--QCILLPVSSLLLYIIKIGGDYFFIYAWLFTLVVSLVLVTIYADYIAPLFDK 225

  Fly   245 SRKMNSTDMDNSLKAVLDDFNFP-GRVYMVH-TFHVGRPTAWVMGCCCCLRLDIHDNLKWNRGFS 307
            ...:....:...::.:....:|| .:||:|. :.......|:..|.....|:.:.|.|.......
Human   226 FTPLPEGKLKEEIEVMAKSIDFPLTKVYVVEGSKRSSHSNAYFYGFFKNKRIVLFDTLLEEYSVL 290

  Fly   308 SDDF--DWG-------------------QMGAGLNDEQLAAFVAHQLAHWQLWHVAKGLALIYFY 351
            :.|.  |.|                   ....|..:|::.|.:.|:|.||:|.|..|.:.:....
Human   291 NKDIQEDSGMEPRNEEEGNSEEIKAKVKNKKQGCKNEEVLAVLGHELGHWKLGHTVKNIIISQMN 355

  Fly   352 LLIYLLLFGICNRWITLYAAAGFTTFYPSSVGFWLVYKYLMPIYHDISTWIVFFCIRHFEYAADA 416
            ..:...||.:......|:||.||....|:.:|..::::::...|:::.::.:....|.||:.|||
Human   356 SFLCFFLFAVLIGRKELFAAFGFYDSQPTLIGLLIIFQFIFSPYNEVLSFCLTVLSRRFEFQADA 420

  Fly   417 YVNRRGYGLPMRAALLKLFSDDYEFPYVDQCYLMWHRLRPSVLQRIDNLQRL 468
            :..:.|....:.:||:||..|:..||..|..:.|||...|.:|:|:..|:.:
Human   421 FAKKLGKAKDLYSALIKLNKDNLGFPVSDWLFSMWHYSHPPLLERLQALKTM 472

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG7573	NP_729695.2	Peptidase_M48_N	62..240	CDD:293100	36/185 (19%)
		Peptidase_M48	<320..466	CDD:299867	40/145 (28%)
ZMPSTE24	NP_005848.2	Peptidase_M48_N	41..225	CDD:293100	37/189 (20%)
		HtpX	124..475	CDD:223575	75/355 (21%)
		Peptidase_M48	228..472	CDD:279743	55/243 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147975
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0501
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S1184
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D407946at33208
OrthoFinder	1	1.000	-	-		FOG0002450
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10120
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	8	7.760