DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment scyl and Ddit4

DIOPT Version :9

Sequence 1:	NP_648456.2	Gene:	scyl / 39270	FlyBaseID:	FBgn0041094	Length:	280	Species:	Drosophila melanogaster
Sequence 2:	NP_083359.1	Gene:	Ddit4 / 74747	MGIID:	1921997	Length:	229	Species:	Mus musculus

Alignment Length:	221	Identity:	54/221 - (24%)
Similarity:	99/221 - (44%)	Gaps:	32/221 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 TTSTSSSIKHKQPA---------GSSNNNVGQSQSKKTKPSGSYNSNSNYYYYAADEEEGGSADY 118
            ::|:|||...:.||         ||:....|..:....:.|...:.:|:...:..:|:.......
Mouse     9 SSSSSSSSSSRTPAADRPPRSAWGSAAREEGLDRCASLESSDCESLDSSNSGFGPEEDSSYLDGV 73

  Fly   119 ALSNY-------DKKAVEELSLRLLDELRAAKSRHLTCTEVSLPCDLTPSVAREIIRVSEKEPRG 176
            :|.::       |:.....|...|.:.|..|:........:.:|..|...|.:|::|::..||.|
Mouse    74 SLPDFELLSDPEDEHLCANLMQLLQESLSQARLGSRRPARLLMPSQLVSQVGKELLRLAYSEPCG 138

  Fly   177 IRGCTIYIEFEDEPKNSRRIASIKVDSDTVSTFEVYLTLRQDHRGW-----------TSLLPQFM 230
            :||..:.:..| :.|:...:|.:.:|...|.||::.|.||.|.|.|           :||:|.:.
Mouse   139 LRGALLDVCVE-QGKSCHSVAQLALDPSLVPTFQLTLVLRLDSRLWPKIQGLLSSANSSLVPGYS 202

  Fly   231 KSLARTITISPEYTITKNKLYSADGL 256
            :||    |:|..:.:.|.||||::.|
Mouse   203 QSL----TLSTGFRVIKKKLYSSEQL 224

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
scyl	NP_648456.2	RTP801_C	139..252	CDD:285100	35/123 (28%)
Ddit4	NP_083359.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..68		12/58 (21%)
Ddit4	NP_083359.1	RTP801_C	101..220	CDD:311657	35/123 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167837698
Domainoid	1	1.000	80	1.000	Domainoid score	I8565
eggNOG	1	0.900	-	-		E1_28WN4
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	77	1.000	Inparanoid score	I5234
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1588396at2759
OrthoFinder	1	1.000	-	-		FOG0004358
OrthoInspector	1	1.000	-	-		mtm8895
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12478
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6013
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.890