DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir68a and grik1a

DIOPT Version :9

Sequence 1:	NP_648455.2	Gene:	Ir68a / 39269	FlyBaseID:	FBgn0036150	Length:	704	Species:	Drosophila melanogaster
Sequence 2:	XP_009303592.1	Gene:	grik1a / 798001	ZFINID:	ZDB-GENE-030131-6502	Length:	919	Species:	Danio rerio

Alignment Length:	711	Identity:	146/711 - (20%)
Similarity:	247/711 - (34%)	Gaps:	187/711 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 SLAMATSIPIPIANPAPLSGYEMQLKILLQKILWVANVKRCFAVITDDLHYPIYDRIFFESV-GR 76
            |:....|:...:|.|.|.||       |:..|:..|      |.:       :||.:|..:| .:
Zfish   294 SVIQKWSMERQLAPPKPESG-------LMSGIMTTA------AAL-------MYDAVFMVAVASQ 338

  Fly    77 RVIPFFVMRTNESDDLQ----RPSRQVELFVKAIKSSDCELNVITILNGWQVQRFLGYIYDNRSL 137
            |.....|      ..||    :|.|....|:...|.:             |.....|.|..|::.
Zfish   339 RATQMTV------SSLQCHRHKPWRYGPRFMNLFKEA-------------QWDGLTGRIVLNKTD 384

  Fly   138 NMQKKFVLLHDLRLFESDMIHLWSVFIDAIFLKRQLDNKYTISTIAFPGILSGVLVMKNIANWEL 202
            .::|:|.|                   |.|.||.....|......:.|..|     ...|..|..
Zfish   385 GLRKEFNL-------------------DLISLKEDGTAKRVADGASRPNKL-----WTKIGVWNS 425

  Fly   203 GKGLNGRILFADK--TSNLFGTSLPVAISEHVPMVLWANATK------SFQGVEVEIMNALGKAL 259
            ..|||...:..:|  |.:|...:|.|......|.|::..:.|      .|:|..::::..|...|
Zfish   426 YTGLNLTEIKDNKNITDSLANRTLIVTTILENPYVMYKKSDKVLYGNDRFEGYCLDLLKELSNIL 490

  Fly   260 NFKPVYYKPNQTENMDWTELDGGASVAYGSGNPDGYAQNGTHIDSMLVDEVAAHSARFAIGDLHL 324
            .|.   |:....       .||    .||:.|..| ..||      :|.|:..|.|..|:..|.:
Zfish   491 GFT---YEVKLV-------TDG----KYGAQNDKG-EWNG------MVRELIDHIADLAVAPLTI 534

  Fly   325 FQVYLKLVELSAPHNFECLTFLT--------PESSTDNSWQTFILPFSAGMWVGVLLSLFVVGTV 381
            ..|..|:::.|.|       |:|        ..:.|:....:|:.|.:..:|:.|||:...|..|
Zfish   535 TYVREKVIDFSKP-------FMTLGISILYRKPNGTNPGVFSFLNPLTPDIWMYVLLACLGVSCV 592

  Fly   382 FYAISFLNAIINGNVSSEFFRCLRPNRNVPMDPKIYRRISFRIAISRYRSSKGDRMPRDLFDGYT 446
            .:.|:....          :....|:   |.:|      |..:..:.:.              ..
Zfish   593 LFVIARFTP----------YEWYNPH---PCNP------SSEVVENNFT--------------LL 624

  Fly   447 NCILLTYSMLLYVALPRMPRNWPLRVLTGWYWIYCILLVATYRASFTAILANPAARVTIDTLEDL 511
            |.:....:.|:......||:....|:|.|.:|.:.::::::|.|:..|.|........||:.:||
Zfish   625 NSLWFGVAALMRQGSELMPKALSTRILGGIWWFFTLIIISSYTANLAAFLTVERMDSPIDSADDL 689

  Fly   512 LR----SHIPPSTGATENRQFFLEANDEVARKVG--EKMEVFGYSDDLTSRIAKGQCAYYDNEFY 570
            .:    .:.....|:|  ..||.::      |:.  |||..|     ::||  |......:::..
Zfish   690 AKQTRIEYGAVRDGST--MTFFKKS------KISTYEKMWAF-----MSSR--KNTALVKNSKDG 739

  Fly   571 LRYLRVAD-----ESGSALHI-MKECVLYMPVVLAMEK--------NSALKPRVDASIQHLAEGG 621
            :..:...|     ||.|..:| .:.|.|.....|...|        .|..:.:|..:|..|.|.|
Zfish   740 ITRVLTTDYALLMESTSIEYITQRNCNLTQVGGLIDSKGYGVGTPIGSPYRDKVTIAILQLQEEG 804

  Fly   622 LI----AKWLKDAIEHLPAEALAQQEALMNIQKFWSSFVALLIGYVISMLTLLAERWHFKH 678
            .:    .||.:.  ...|.|...:..|| .::.....|:.|..|.|:|:...:.|..:..|
Zfish   805 KLHMMKEKWWRG--NGCPEEDSKEASAL-GVENIGGIFIVLAAGLVLSVFVAIGEFIYKSH 862

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir68a	NP_648455.2	Lig_chan	429..661	CDD:278489	51/255 (20%)
grik1a	XP_009303592.1	Periplasmic_Binding_Protein_Type_1	37..432	CDD:299141	42/200 (21%)
		ANF_receptor	57..398	CDD:279440	32/161 (20%)
		Periplasmic_Binding_Protein_Type_2	446..815	CDD:304360	90/444 (20%)
		Lig_chan	577..846	CDD:278489	62/319 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591166
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.740