DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir68a and grid1a

DIOPT Version :9

Sequence 1:	NP_648455.2	Gene:	Ir68a / 39269	FlyBaseID:	FBgn0036150	Length:	704	Species:	Drosophila melanogaster
Sequence 2:	XP_021323097.1	Gene:	grid1a / 793756	ZFINID:	ZDB-GENE-120411-28	Length:	1044	Species:	Danio rerio

Alignment Length:	525	Identity:	102/525 - (19%)
Similarity:	186/525 - (35%)	Gaps:	121/525 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   194 MKNIANWELGKGLNGRILFADKTSNLFGTSLPVAISEHVPMVLWA----NATKSFQGVEVEIMNA 254
            :|.:|.|:..:||||.:........:.|.:|.|......|.|:.|    ...|.::|..:::::|
Zfish   410 VKRLATWDSDRGLNGSLRENRADHGMQGITLKVVTLLEEPFVMVAENILGQPKRYKGFSIDVLDA 474

  Fly   255 LGKALNFKPVYYKPNQTENMDWTELDGGASVAYGSGNPDGYAQNGTHIDSMLVDEVAAHSARFAI 319
            |.|.|.||...|:.              |...|||...:| :.||      ::.|:....|..||
Zfish   475 LAKILGFKYEMYQV--------------ADAKYGSPQTNG-SWNG------MIGELIGKRADVAI 518

  Fly   320 GDLHLFQVYLKLVELSAPHNFECLTFLTPESSTDNSWQTFILPFSAGMWVGVLLSLFVVGTVFYA 384
            ..:.:......:|:.|..:....:..|..::....:..:.:.||...:|..:..::.|||.:.:.
Zfish   519 SAITITPERENVVDFSKRYLDYSVGILMTKTEERLNIFSLLAPFDLAVWACIAAAIPVVGVMVFL 583

  Fly   385 ISFLNAIINGNVSSEFFRCLRPNRNVPMDPKIYRRISFRIAISRYRSSKGDRMPRDLFDGYTNCI 449
            :.                                    |:...|.::..|...|..:...:.:.|
Zfish   584 LR------------------------------------RVQSVRSQNPPGPHQPASVTTSFQSAI 612

  Fly   450 LLTYSMLLYVALPRMPRNWPLRVLTGWYWIYCILLVATYRASFTAILANPAARVTIDTLEDLLR- 513
            .:.|...:.........:..||:..|.:|::.:::.::|.|:..|.|........|.|.:||.:
Zfish   613 WIVYGAFVQQGGESFMSSMALRIAMGSWWLFTLIVCSSYTANLAAYLTVSRMDNAIRTFQDLSKQ 677

  Fly   514 SHIPPSTGATENRQFF----------LEAND---EVARKVGEKMEVFGYSDDLTS------RIAK 559
            |.|  :.|.......|          ||.:.   |:.|.:.:..   |..:.:||      ::.:
Zfish   678 SEI--NYGTVRESAVFEYFRVKGTNPLEQDSTFAELWRTINKNQ---GQDNSVTSPAEGIRKVKR 737

  Fly   560 GQCAYYDNEFYLRYLRVADESGSALHIMKECVLYMPVV-----------LAMEKNSALKPRVDAS 613
            ...|:..:...|.|..:.|:         :|.|   ||           ||::..|..:......
Zfish   738 DPYAFLWDMAVLEYAALTDD---------DCTL---VVTGNGMSSKGYGLALQHGSPYRDLFSQK 790

  Fly   614 IQHLAEGG----LIAKWLK-----DAIEHLPAEALAQQEALMNIQKFWSSFVALLIGYVISMLTL 669
            |..|.|.|    |..||..     |..:|  ||...:..|| .:..|...|..|..|.:::.|..
Zfish   791 ILDLQEKGDLDILKQKWWPRKGRCDLDKH--AEPQTEGRAL-RLHSFAGVFCILAAGLLLACLVA 852

  Fly   670 LAERW 674
            ..|.|
Zfish   853 ALESW 857

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir68a	NP_648455.2	Lig_chan	429..661	CDD:278489	54/271 (20%)
grid1a	XP_021323097.1	Periplasmic_Binding_Protein_Type_1	25..424	CDD:324556	5/13 (38%)
		PBP2_iGluR_delta_1	437..809	CDD:270448	82/445 (18%)
		DNA_pol3_gamma3	<915..1044	CDD:331207
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591103
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.740