DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir68a and grin3ba

DIOPT Version :9

Sequence 1:	NP_648455.2	Gene:	Ir68a / 39269	FlyBaseID:	FBgn0036150	Length:	704	Species:	Drosophila melanogaster
Sequence 2:	XP_021323058.1	Gene:	grin3ba / 566411	ZFINID:	ZDB-GENE-070912-354	Length:	1118	Species:	Danio rerio

Alignment Length:	751	Identity:	147/751 - (19%)
Similarity:	246/751 - (32%)	Gaps:	215/751 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 QLKILLQKILWVANVKRCFAVITDDLH---YPIYDRIFFESVGRRVIPFFVMRTNESDDLQRPSR 97
            ||...|..:.|:..    :.:..|.||   .|: ..:.:..|.|:.:.|::     .|.||...|
Zfish   271 QLSGTLPPMHWIMG----YPLSLDSLHSIGSPL-GLMAYGEVNRKPLNFYI-----RDTLQLIGR 325

  Fly    98 QVELFVKAIKSSDCEL--NVITIL----------NGWQVQRFLGYIYDNRS-------LNMQKKF 143
            .|  :...:...|..|  |::...          :|..:.|||    .|.|       :.:::.|
Zfish   326 AV--YAATMVRPDLALIQNMVNCFDKPNKHELPSSGQYLARFL----SNTSFTGLTGPVRVERSF 384

  Fly   144 VLLHDLRLFESDMIHLWSVFIDAIFLKRQLDNKYTISTIAFPGILSGVLVMKNIANW-------- 200
                 .|:..|...|:||:         |.|.....|.:......||.|.::....|
Zfish   385 -----SRVLTSQRFHIWSL---------QRDPLGQPSWVTVASWQSGRLELEEQGLWPGVTQHQR 435

  Fly   201 ELGKG--LNGRILFADKTSNLFGTSLPVA--------ISEHVPMV-------------------- 235
            |.|.|  |.||          :...||||        :.|| |.|
Zfish   436 EDGPGIRLGGR----------WQAGLPVAGSRLRVVTLVEH-PFVFTREVDEEGQCPAGQLCLDP 489

  Fly   236 ----------------------LWANATKSFQGVEVEIMNALGKALNFKPVYYKPNQTENMDWTE 278
                                  |..:..|...|..::::..|.:.::|:           .|...
Zfish   490 QTNNSEVLNQLFRELEQTNSSSLPTDMRKCCYGYCIDLLEKLAEDMHFE-----------FDLYI 543

  Fly   279 LDGGASVAYGSGNPDGYAQNGTHIDSMLVDEVAAHSARFAIGDLHLFQVYLKLVELSAPHNFECL 343
            :..|...|:..|...|           ||.::.:..|..|:....:.....::::.::|.....|
Zfish   544 VGDGKYGAWKGGRWSG-----------LVGDLLSGVADMAVTSFSINSARSRVIDFTSPFFSTSL 597

  Fly   344 TFLTPESSTDNSWQTFILPFSAGMWVGVLLSLFVVGTVFYAISFLNAIINGNVSSEFFRCLRPNR 408
            ..|.....|......|:.|....||||:.::|                   ::::.|......|.
Zfish   598 GILVRSKDTAAPIGAFMWPLHWSMWVGIFVAL-------------------HITALFITLYEWNS 643

  Fly   409 NVPMDPKIYRRISFRIAISRYRSSKGDRMPRDLFDGYTNCILLTYSMLL-YVALPRMPRNWPLRV 472
            ...|.|....||.                   :| .|::.:.|.|::|. .....:.|:.|..|.
Zfish   644 PFGMTPHGRNRIR-------------------VF-SYSSALNLCYAILFGRTVASKTPKCWTGRF 688

  Fly   473 LTGWYWIYCILLVATYRASFTAILANPAARVTIDTLEDLLRSHIPPSTGATENRQFFLEANDEVA 537
            |...:.|:|:|::::|.|:..|::........:..:.|:...|  ||.|..........|.|.|.
Zfish   689 LMNLWAIFCLLVLSSYTANLAAVMVGEKTFEEVSGIHDVKLHH--PSLGFRFGTVRESSAEDYVK 751

  Fly   538 RKVGEKMEVF----------GYSDDLTSRIAKGQC-AYYDNEFYLRYLRVADESGSALHIMKECV 591
            :...|..|..          |.|   |.:....|. |:..::..|.|....|.....|.:.|...
Zfish   752 KSFPEMHEYMRRFNKPTTPDGVS---TLKTDPPQLDAFIMDKALLDYEVSIDADCKLLTVGKPFA 813

  Fly   592 L--YMPVVLAMEKNSALKPRVDASIQHLAEGG----LIAKWLKDAIEHLPAEALAQQEAL-MNIQ 649
            :  |   .:.:.:||.|...|...:......|    |..||.|  :........|..|.| |.||
Zfish   814 IEGY---GIGLPQNSPLTRNVSEYVSRYKSDGYMDMLHDKWYK--VVPCGKRVFAVTETLQMGIQ 873

  Fly   650 KFWSSFVALLIGYVISMLTLLAERWHFKHIV--MKH 683
            .|...||.|.:|...::||||.|...|:.|:  ::|
Zfish   874 HFSGLFVLLCVGVAGALLTLLGEHAFFRFILPHLRH 909

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir68a	NP_648455.2	Lig_chan	429..661	CDD:278489	55/250 (22%)
grin3ba	XP_021323058.1	Periplasmic_Binding_Protein_Type_1	26..428	CDD:324556	37/186 (20%)
grin3ba	XP_021323058.1	PBP2_iGluR_NMDA_Nr3	457..852	CDD:270438	78/464 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591172
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.740