DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir68a and grin3a

DIOPT Version :9

Sequence 1:	NP_648455.2	Gene:	Ir68a / 39269	FlyBaseID:	FBgn0036150	Length:	704	Species:	Drosophila melanogaster
Sequence 2:	XP_009303361.1	Gene:	grin3a / 564832	ZFINID:	ZDB-GENE-130530-780	Length:	1111	Species:	Danio rerio

Alignment Length:	724	Identity:	134/724 - (18%)
Similarity:	241/724 - (33%)	Gaps:	217/724 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 FAVITDDLHYPIYDRIFFESVGRRVIPFFVMRTNESDDLQRPSRQ------VELFVKAIKS---- 108
            |.:|..|.|:.|.|....|.:....:|..::....   :..||..      :||..:|:.|
Zfish   349 FGLILPDYHWIIGDSQNVEELRTEGLPMGLLAHGR---MGEPSLDHYVQDALELVARAVGSAATV 410

  Fly   109 ----------SDC--ELNVITILNGWQVQRFLGYI-YDNRS--LNMQKKFVLLHDLRLFESDMIH 158
                      ::|  .|....:.:|..:.|::... :|..|  :::|::..::.:...|
Zfish   411 SPQLALIPGTTNCLARLEAKNLTSGTFLSRYMASTSFDGLSGCISVQEESTIISESHHF------ 469

  Fly   159 LWSVFIDAIFLKRQLDNKYTISTIAFPGILSGVLVMKNIANWELGKGLNGRILFADKTSNLFGTS 223
            :|::..|.|                      |..:...:.:|:.||.:....::.:|..:..|..
Zfish   470 IWNLQHDPI----------------------GKPMWTRLGSWKHGKVVMDYGVWPNKRRSQPGAD 512

  Fly   224 ---------LPVAISEHVPMVLWANATKS-----------------------FQGVE-------- 248
                     ..|.:.|| |.|...:....                       |||::
Zfish   513 WRHSSRLHLRVVTLVEH-PFVFTRDVDDEGLCPAGQLCLDPLTNDTALLESLFQGLQGANDTVPL 576

  Fly   249 ----------VEIMNALGKALNFKPVYYKPNQTENMDWTELDGGASVAYGSGNPDGYAQNGTHID 303
                      ::::..|.:.:.|           :.|...:..|...||.:|...|
Zfish   577 EFKKCCYGYCIDLLEKLAEDMGF-----------DFDLYIVGDGKYGAYKNGRWTG--------- 621

  Fly   304 SMLVDEVAAHSARFAIGDLHLFQVYLKLVELSAPHNFECLTFLTPESSTDNSWQTFILPFSAGMW 368
              ||.::.:.:|..|:....:.....::::.::|.....|..|.....|......|:.|....||
Zfish   622 --LVGDLMSGAAHLAVTSFSINSARSQVIDFTSPFFSTSLGILVRTRDTAAPIGAFMWPLHWSMW 684

  Fly   369 VGVLLSLFVVGTVFYAISFLNAIINGNVSSEFFRCLRPNRNVPMDPKIYRRISFRIAISRYRSSK 433
            :|:.:||.|. .||..:               :....|....|                |.|:
Zfish   685 LGIFVSLHVT-AVFLTL---------------YEWKSPFGMTP----------------RGRN-- 715

  Fly   434 GDRMPRDLFDGYTNCILLTYSMLL-YVALPRMPRNWPLRVLTGWYWIYCILLVATYRASFTAILA 497
                 ||....:::.:.:.|::|. ..|..:.|:.|..|.|...:.|:|:..::||.|:..|::
Zfish   716 -----RDRVFSFSSALNVCYAILFGRTAAIKPPKCWTGRFLMNLWAIFCLFCLSTYTANLAAVM- 774

  Fly   498 NPAARVTIDTLEDLLRSHIP----PSTGATENRQFFLEANDEVARKVGEKMEVF-GYS------- 550
                 |...|.|.|...|.|    ||.|..........|.|.|.:...|..|.. .|:
Zfish   775 -----VGEKTYEQLSGIHDPKLHHPSQGFRFGTVRESSAEDYVKKSFPEMHEYMRRYNAPTTPDG 834

  Fly   551 -DDLTSRIAKGQCAYYDNEFYLRYLRVADESGSALHIMKECVLYMPVVL-----AMEKNSALKPR 609
             |.|.....|.. |:..::..|.|...||:.            |:.::|     .:::||.|...
Zfish   835 IDHLKDDPQKLD-AFIMDKALLDYWAHADKX------------YISLLLTGYGIGLKQNSPLTSN 886

  Fly   610 VDASIQHLAEGG----LIAKWLKDAIEHLPAEALAQQEAL-MNIQKFWSSFVALLIGYVISMLTL 669
            :...:......|    |..||.|  :......:.|..|.| |.|:.|...||.|.:|..:|:||.
Zfish   887 ISELVSQYKSDGFMDMLHDKWYK--VVPCGKRSFAVTETLQMGIKHFSGLFVMLCVGVALSLLTT 949

  Fly   670 LAE----RW 674
            |.|    ||
Zfish   950 LGEHIVHRW 958

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir68a	NP_648455.2	Lig_chan	429..661	CDD:278489	58/255 (23%)
grin3a	XP_009303361.1	Periplasmic_Binding_Protein_Type_1	36..502	CDD:299141	29/183 (16%)
		ANF_receptor	132..452	CDD:279440	19/105 (18%)
		PBP2_iGluR_NMDA_Nr3	518..908	CDD:270438	84/470 (18%)
		Lig_chan	682..941	CDD:278489	69/318 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591173
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.740