DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir68a and grin2aa

DIOPT Version :9

Sequence 1:	NP_648455.2	Gene:	Ir68a / 39269	FlyBaseID:	FBgn0036150	Length:	704	Species:	Drosophila melanogaster
Sequence 2:	XP_021329529.1	Gene:	grin2aa / 563297	ZFINID:	ZDB-GENE-070424-129	Length:	1460	Species:	Danio rerio

Alignment Length:	559	Identity:	106/559 - (18%)
Similarity:	188/559 - (33%)	Gaps:	145/559 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   191 VLVMKNIANWE-LGKGLNGRILFADKT---SNLFGTS------LPVAISEHVPMVLWANA----- 240
            |:|:.....|| :||..|..:......   .|.||.:      |.:...|..|.|:..|.
Zfish   360 VIVLNKDREWEKMGKWENQSLTLKYPVWPRFNSFGDAETDDNHLTIVTLEEKPFVIVENVERLTG 424

  Fly   241 -------------------------TKSFQGVEVEIMNALGKALNFKPVYY-----KPNQTENMD 275
                                     .|..:|..::|:..:.:.:.|....|     |..:..|..
Zfish   425 TCMRNSVPCRKHIKDNTTEGGGTYIKKCCKGFCIDILKKIARNVKFTYDLYLVTNGKHGKKINNV 489

  Fly   276 WTELDGGASVAYGSGNPDGYAQNGTHIDSMLVDEVAAHSARFAIGDLHLFQVYLKLVELSAPHNF 340
            |                     ||      :|.||....|..|:|.|.:.:...::::.|.|...
Zfish   490 W---------------------NG------MVGEVVNKKAVMAVGSLTINEERSEVIDFSVPFVE 527

  Fly   341 ECLTFLTPESSTDNSWQTFILPFSAGMWVGVLLSLFVVGTVFYAISFLNAIINGNVSSEFFRCLR 405
            ..::.:...|:...|...|:.||||.:||.:.:.|.:| |......|           |:...|.
Zfish   528 TGISVMVSRSNGTVSPSAFLEPFSASVWVMMFVMLLLV-TAMAVFMF-----------EYISPLG 580

  Fly   406 PNRNV-----PMDPKIYRRISFRIAISRYRSSKGDRMPRDLFDGYTNCILLTYSMLLYVALP-RM 464
            .|||:     |..|      ||.:.                     ..:.|.:.::...::| :.
Zfish   581 FNRNLAQGKDPHGP------SFTMG---------------------KAVWLLWGLVFNNSVPVQN 618

  Fly   465 PRNWPLRVLTGWYWIYCILLVATYRASFTAILANPAARVTIDTLEDLL----RSHIPP------S 519
            |:....:.:...:..:.::.:|:|.|:..|.:........:..|.|..    .|:.||      .
Zfish   619 PKGTTSKFIVSVWAFFAVIFLASYTANLAAFMIQEEFVDQVTGLSDKKFQSPYSYSPPFRFGTVP 683

  Fly   520 TGATENRQFFLEANDEVARKVGEKMEVFGYSDDLTS-RIAKGQCAYYDNEFYLRYLRVADESGSA 583
            .|:||..   :..|.....:...|....|.:|.|.| :..|.....|| ...|.|:...|| |..
Zfish   684 NGSTERN---IRKNYPDMHQYMVKYHQTGVNDALVSLKTGKLDAFIYD-AAVLNYMAGRDE-GCK 743

  Fly   584 LHIMKECVLYMPV--VLAMEKNSALKPRVDASIQHLAEGG----LIAKWLKDAIEHLPAEALAQQ 642
            |..:....::...  .:|::|.|..|..||.:|..:...|    |.|:||.....:...|.::.|
Zfish   744 LVTIGSGYIFATTGYGIALQKGSLWKRPVDLAILAIIGDGEMEELEAQWLTGICHNEKNEVMSSQ 808

  Fly   643 EALMNIQKFWSSFVALLIGYVISMLTLLAER---WHFKH 678
               :::......|..|.....:|::|.:.|.   |..::
Zfish   809 ---LDVDNMAGVFYMLATAMGLSLITFVWEHLFYWRLRY 844

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir68a	NP_648455.2	Lig_chan	429..661	CDD:278489	46/249 (18%)
grin2aa	XP_021329529.1	PBP1_iGluR_NMDA_NR2	33..389	CDD:107373	7/28 (25%)
		PBP2_iGluR_NMDA_Nr2	400..799	CDD:270436	88/469 (19%)
		NMDAR2_C	836..1460	CDD:313729	1/9 (11%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591160
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.740